Results 61 to 70 of about 77,359 (282)
Investigation of effects of two environmental heavy metals in a combined exposure model on the nervous system in rats [PDF]
, 2012 In the present study, the interaction of inhalational and oral exposure to manganese and lead was investigated. Young adult male Wistar rats (2 x 10 per group) were treated orally with MnCl2 (15 and 60 mg/kg b.w.) or Pb acetate (80 and 320 mg/kg) for 3 ...
Horváth, Edina +3 more
core
Pathogenesis of chronic obstructive pulmonary disease [PDF]
, 2005 The current paradigm for the pathogenesis of chronic obstructive pulmonary disease is that chronic airflow limitation results from an abnormal inflammatory response to inhaled particles and gases in the lung. Airspace inflammation appears to be different
Macnee, W
core +2 more sources
Advanced Science, EarlyView.The S100A4/STAT3 axis promotes Rmrp transcription in AEC‐IIs and Rmrp expression in AEC‐II‐derived exosomes. Upon entry into AMs, Rmrp binds to and blocks the ubiquitination and degradation of ZFP36. Increased ZFP36 induced Pfkfb3 mRNA decay by binding to AREs in the 3′ UTR, curbing glycolysis and immune responses of AMs and aggravating SII and ...
Chengxi Liu +17 more
wiley +1 more source
Comparison of ILMA Guided Tracheal Intubation in the Lateral Position with the Supine Position
Asian Journal of Medical Sciences, 2013 Background: The ILMA has been established as a valuable airway management device in the supine position, in both elective and emergency situations, for both ventilation and intubation.
Manish Naithani
doaj +1 more source
Intratracheal Administration of Chloroquine-Loaded Niosomes Minimize Systemic Drug Exposure
Pharmaceutics, 2021 Pulmonary administration provides a useful alternative to oral and invasive routes of administration while enhancing and prolonging the accumulation of drugs into the lungs and reducing systemic drug exposure. In this study, chloroquine, as a model drug,
Hesham A. Saafan +8 more
doaj +1 more source
Advanced Science, EarlyView.The study identifies elevated homocysteine (Hcy) levels in idiopathic pulmonary fibrosis patients' samples, with alveolar type 2 cells as the primary site of Hcy metabolism. Methionine synthase reductase downregulation in these cells exacerbates fibrosis, while folate administration reduces Hcy levels and alleviates fibrosis.
Jiefeng Huang +14 more
wiley +1 more source
A fiberoptic orotracheal intubation successfully performed using a modified Guedel airway in a sedated emergency patient - A case report - [PDF]
Anesthesia and Pain Medicine, 2020 Background Fiberoptic intubation is a powerful and safe technique to deal with airway difficulty, but it requires a lot of training to be able to perform correctly.
Jaeyoung Yang +8 more
doaj +1 more source
Diesel Exhaust Activates & Primes Microglia: Air Pollution, Neuroinflammation, & Regulation of Dopaminergic Neurotoxicity [PDF]
, 2011 BACKGROUND: Air pollution is linked to central nervous system disease, but the mechanisms responsible are poorly understood. OBJECTIVES: Here, we sought to address the brain-region-specific effects of diesel exhaust (DE) and key cellular mechanisms ...
Block, Michelle L +10 more
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Multifunctional nanocarriers for lung drug delivery [PDF]
, 2020 Nanocarriers have been increasingly proposed for lung drug delivery applications. The strategy of combining the intrinsic and more general advantages of the nanostructures with specificities that improve the therapeutic outcomes of particular clinical ...
Grenha, Ana, Pontes, Jorge Filipe
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Advanced Science, EarlyView.SCAP/ARDS patients show reduced unsaturated fatty acids (UFAs) but higher PARK7 and lactate in plasma. PARK7 correlates positively with lactate and negatively with UFAs. Pulmonary endothelial cell multi‐omics show FADS1/2 downregulation and impaired PUFA metabolism. Lactate boosts PARK7 via H3K14 lactylation, and PARK7 then restores FADS1/2.
Jian Xu +11 more
wiley +1 more source