Results 111 to 120 of about 700,178 (349)

Development of a decision analytic model to support decision making and risk communication about thrombolytic treatment [PDF]

, 2015
Background Individualised prediction of outcomes can support clinical and shared decision making. This paper describes the building of such a model to predict outcomes with and without intravenous thrombolysis treatment following ischaemic stroke ...
A Bannat, D Kraft, F Bernardini, J Aleotti, J Ilonen, J Prankl, M Krainin, SM Olesen   +7 more
core   +2 more sources

“Time Is Brain” – for Cell Therapies

Advanced Science, EarlyView.
The concept that “time is brain” extends to stem cell therapy for stroke. Evidence across preclinical and clinical studies indicates that delivery timing shapes graft survival, integration, and efficacy by matching the evolving post‐stroke microenvironment.
Hao Yin, Dominikus Brian, Rebecca Z. Weber, Patrick D. Lyden, Ruslan Rust   +4 more
wiley   +1 more source

Thrombolysis in Patients Aged over 80 Years Is Equally Effective and Safe [PDF]

, 2016
BACKGROUND: Despite stroke's high prevalence in the elderly, intravenous thrombolysis is licensed in Europe only for patients younger than 80 years old.
Amaral-Silva, A, Ferreira, P, Paiva Nunes, A, Pego, PM, Sousa, C   +4 more
core   +2 more sources

All Nanozyme‐Based Cascade Reactions for Biomedical Applications: from Self‐Cascading Nanozyme to Immobilized Cascade Nanozyme

Advanced Science, EarlyView.
This review introduces the development and classification of all‐nanozyme cascade reaction systems, highlighting mechanistic insights and research methods for understanding catalytic features and design principles. It provides detailed classifications, surveys recent applications in biosensing and therapy, and discusses the challenges that all‐nanozyme
Caixia Zhu, Congcong Jiang, Hian Kee Lee, Yuanjian Zhang, Sheng Tang   +4 more
wiley   +1 more source

Results of the MRI substudy of the intravenous magnesium efficacy in stroke trial [PDF]

, 2009
<p><b>Background and Purpose:</b>Although magnesium is neuroprotective in animal stroke models, no clinical benefit was confirmed in the Intravenous Magnesium Efficacy in Stroke (IMAGES) trial of acute stroke patients.
Alger, J.R., Chen, C., Davis, S.M., De Silva, D.A., Kidwell, C.S., Lees, K.R., Muir, K.W., Saver, J.L., Starkman, S., Weir, C.J.   +9 more
core   +1 more source

Intravenous Thrombolysis in Posterior Cerebral Artery Infarctions [PDF]

Cerebrovascular Diseases, 2011
<i>Background:</i> Approximately 5–10% of all acute ischemic strokes (AIS) occur in the territory of the posterior cerebral artery (PCA). Little is known about intravenous thrombolysis (IVT) in this infarct subgroup in terms of outcome and intracerebral hemorrhage rates.
Breuer, Lorenz, Huttner, Hagen B., Jentsch, K., Blinzler, Christian, Winder, Klemens, Engelhorn, Tobias, Köhrmann, Martin   +6 more
openaire   +3 more sources

Amelioration of Post‐Stroke Edema and Microcirculatory Dysfunction via Targeted AQP4 Inhibition While Preserving the Glymphatic System

Advanced Science, EarlyView.
Compared to untargeted therapy, the targeted nanocarrier, Angiopep‐2‐conjugated Lipid Nanoparticle (A‐LNP) loaded with TGN‐020 (TGN), selectively accumulated in stroke‐injured regions. It suppressed local aquaporin‐4 (AQP4) overexpression, thereby alleviating cerebral edema and hypoperfusion while preserving global glymphatic clearance.
Lei Jin, Zeyu Yang, Boyang Wei, Yu Wu, Longxiang Li, Jiaming Zhou, Xin Zhang, Fa Jin, Shixing Su, Yanchao Liu, Ran Li, Shenquan Guo, Xingwu Liu, Yu Cai, Hong Liu, Min Chen, Wenchao Liu, Chuanzhi Duan, Xifeng Li   +18 more
wiley   +1 more source

Carotid Endarterectomy Following Intravenous Thrombolysis in the UK [PDF]

, 2021
Amundeep S. Johal, A. Ross Naylor, Arun Pherwani, Qiuju Li, Panagiota Birmpili, Sam Waton, Richard O’Neill, Jonathan R. Boyle, David Cromwell   +8 more
openalex   +1 more source

Tenecteplase Versus Alteplase for First‐Pass Reperfusion in Basilar Artery Occlusion Stroke Thrombectomy

Annals of Neurology, EarlyView.
Objective The first‐pass effect (FPE), defined as excellent reperfusion after a single attempt, is associated with improved outcomes in large vessel occlusion stroke. We evaluated whether intravenous tenecteplase (TNK) compared with alteplase (TPA) increases the likelihood of FPE in basilar artery occlusion (BAO).
Dylan N. Wolman, Rahul R. Karamchandani, Sina Hemmer, Tyler M. Bielinski, Nitin Goyal, Jeremy B. Rhoten, Mahesh V. Jayaraman, Christian T. Sidebottom, Bradley A. Gross, Alhamza R. Al‐Bayati, Mohamed F. Doheim, Matthew K. Tobin, Anoop Chinthala, Avi Gajjar, Justin Mascitelli, Matthew R. Webb, Jan‐Karl Burkhardt, Kyle W. Scott, Visish Srinivasan, Daniel Tonetti, Manisha Koneru, David J. Altschul, Dhrumhil Vaishnav, Sumeet Multani, Thana Theofanis, William J. Ares, Je Yeong Sone, Ramin Zand, Sasan Bahrami, Jiang Li, Gary Defilipp, Dale Strong, Radmehr Torabi, Krisztina Moldovan, Clemens M. Schirmer, Alexandra R. Paul, Bradley N. Bohnstedt, Raul G. Nogueira, Philipp Hendrix   +38 more
wiley   +1 more source

Efficacy and Safety of Intravenous Thrombolysis in Patients with Unknown Onset Stroke: A Meta-Analysis

Behavioural Neurology, 2019
Objectives. Unknown onset stroke (UOS) is usually excluded from intravenous thrombolysis concerning the unclear symptom onset time. Attempts have been done to use thrombolytic therapy in these patients.
Di Luan, Yuanxiang Zhang, Qian Yang, Zhiming Zhou, Xianjun Huang, Shoucai Zhao, Lili Yuan   +6 more
doaj   +1 more source