Results 171 to 180 of about 700,178 (349)

The Efficacy and Safety of Tirofiban Use in Endovascular Thrombectomy for Intravenous Thrombolysis Applicable Patients with Large Vessel Occlusion Stroke—a Post Hoc Analysis from the Direct-MT Trial [PDF]

open access: hybrid, 2023
Yingying Zhang   +13 more
openalex   +1 more source

Iron Overload Mediates the Differential Cell Fate of Astrocytes from Neurons and Its Regulatory Mechanisms in Ischemic Stroke

open access: yesAdvanced Science, Volume 13, Issue 4, 19 January 2026.
Upon ischemia/reperfusion‐induced iron overload condition, neurons and astrocytes exhibit similar oxidative stress changes but opposite alterations in endogenous antioxidant defense mechanisms, leading to divergent ferroptotic outcomes. The iron deposition and neuronal loss are increased within the perilesional cortex of stroke patients ...
Yi Guo   +17 more
wiley   +1 more source

Carbon Monoxide Nanomodulator Reverses Ischemia‐Reperfusion Injury in Stroke: A Novel Dual‐Channel Therapy Mode of Co‐driving Neuroprotection and Neurogenesis

open access: yesAdvanced Science, Volume 13, Issue 1, 5 January 2026.
This work develops a biomimetic and reactive oxygen species‐activated carbon monoxide (CO) nanogenerator to penetrate blood‐brain barrier, arrive in stroke‐affected regions, and release CO in a controlled manner for an innovative dual‐channel therapy strategy via co‐driving neuroprotection and neurogenesis.
Xuegang Niu   +17 more
wiley   +1 more source

Endovascular Therapy Versus Best Medical Treatment in Posterior Cerebral Artery Stroke: A Systematic Review and Meta‐Analysis

open access: yesBrain and Behavior, Volume 16, Issue 1, January 2026.
Graphical abstract representing key findings of our study. ABSTRACT Introduction Posterior cerebral artery (PCA) stroke, while comprising a smaller proportion of ischemic strokes, often results in significant neurological deficits and poses distinctive therapeutic challenges.
Umama Alam   +15 more
wiley   +1 more source

Heads Down for Acute Stroke: Supine Position for Acute Large Vessel Occlusion in Ischemic Stroke

open access: yesClinical Case Reports, Volume 14, Issue 1, January 2026.
ABSTRACT This case demonstrates that for large vessel occlusion strokes in the acute stage before surgical, pharmacologic, or radiologic intervention, supine positioning may be assumed because of the hemodynamic changes that can prevent and alleviate stroke, supporting the results of the ZerO Degree head positioning In Acute ischemiC stroke (ZODIAC ...
Hassaan A. Khan   +20 more
wiley   +1 more source

Rationale and Design of the PASSIVATE‐CAP Trial: The Preventive Intervention Value of Drug‐Coated Balloons in Vulnerable Coronary Atherosclerotic Plaques

open access: yesClinical Cardiology, Volume 49, Issue 1, January 2026.
PASSIVATE‐CAP Research Overview and Flowchart. ABSTRACT Background Patients with acute coronary syndrome (ACS) face a significantly increased risk of cardiovascular events due to vulnerable plaques. However, no clear evidence supports performing preventive percutaneous coronary intervention (PCI) for non‐flow‐limiting vulnerable plaques.
Zhongxiu Chen   +11 more
wiley   +1 more source

Case report: Tenecteplase for acute ischemic stroke after heparin reversal

open access: yesFrontiers in Stroke
Intravenous thrombolysis can be administered to appropriate patients with suspected acute ischemic strokes who are on intravenous heparin infusions after its rapid reversal with protamine sulfate.
Manali Desai   +4 more
doaj   +1 more source

A Novel and Simple Score to Predict Embolic or Atherosclerotic Middle Cerebral Artery Occlusion Before Mechanical Thrombectomy: AHOC Score

open access: yesCNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.
This study developed and validated the novel AHOC score, a simple pre‐thrombectomy tool for predicting stroke etiology (embolism vs. intracranial atherosclerosis) in acute middle cerebral artery occlusion. This score integrates four key clinical/imaging variables—atrial fibrillation, hyperdense artery sign, stenosis/occlusion in other arteries, and ...
Hudie Zhang   +17 more
wiley   +1 more source

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