Results 61 to 70 of about 54,898 (247)

Spectrophotometric analysis of thrombolytic activity: SATA assay [PDF]

, 2017
Introduction: Measurement of thrombolytic activity i.e. clot lysis is crucial for research and development of novel thrombolytics. It is also a key factor in assessment of the effectiveness of conventionally used thrombolytic agents in the clinic, which ...
Entekhabi, Nazila, Eskandani, Morteza, Farhoudi, Mehdi, Mohammadian, Reza, Rafi, Mohammad, Zamanlu, Masumeh   +5 more
core   +2 more sources

Carbon Monoxide Nanomodulator Reverses Ischemia‐Reperfusion Injury in Stroke: A Novel Dual‐Channel Therapy Mode of Co‐driving Neuroprotection and Neurogenesis

Advanced Science, EarlyView.
This work develops a biomimetic and reactive oxygen species‐activated carbon monoxide (CO) nanogenerator to penetrate blood‐brain barrier, arrive in stroke‐affected regions, and release CO in a controlled manner for an innovative dual‐channel therapy strategy via co‐driving neuroprotection and neurogenesis.
Xuegang Niu, Bin Gao, Hongyi Huang, Zesheng Li, Yibin Zhang, Quanlei Liu, Chao Zhang, Yang Dai, Jinkun Xu, Mingshan Liu, Yuanyuan Zhang, Yihe Wang, Penghu Wei, Yuanxiang Lin, Yongzhi Shan, Yumin Luo, Dezhi Kang, Guoguang Zhao   +17 more
wiley   +1 more source

The mechanisms of reperfusion during in stroke patients treated with intravenous thrombolysis

Неврология, нейропсихиатрия, психосоматика, 2012
Systemic (intravenous) thrombolysis with recombinant tissue plasminogen activator (rt-PA) is a proved effective treatment modality in a certain group of patients with ischemic stroke (IS) in the first 4.5 hours after the onset of neurological symptoms ...
Maksim Alekseyevich Domashenko, M Yu Maksimova, M A Loskutnikov, A A Nikonov, V V Bryukhov, A S Suslin, M V Dreval, R N Konovalov   +7 more
doaj   +1 more source

Stroke with unknown time of symptom onset: baseline clinical and magnetic resonance imaging data of the first thousand patients in WAKE-UP (efficacy and safety of mri-based thrombolysis in wake-up stroke: a randomized, doubleblind, placebo-controlled trial) [PDF]

, 2017
Background and Purpose—We describe clinical and magnetic resonance imaging (MRI) characteristics of stroke patients with unknown time of symptom onset potentially eligible for thrombolysis from a large prospective cohort.
Boutitie, Florent, Cheng, Bastian, Cho, Tae-Hee, Ebinger, Martin, Endres, Matthias, Fiebach, Jochen B., Fiehler, Jens, Ford, Ian, Galinovic, Ivana, Gerloff, Christian, Lemmens, Robin, Muir, Keith W., Nighoghossian, Norbert, Pedraza, Salvador, Puig, Josep, Roy, Pascal, Simonsen, Claus Z., Thijs, Vincent, Thomalla, Götz   +18 more
core   +2 more sources

A Metalloporphyrin Nanosystem Enables Non‐Invasive Visualization and Specific Treatment for Thrombosis and Ischemic Stroke

Advanced Science, EarlyView.
Thrombotic ischemic stroke is a severe neurological disease of the brain that presents major challenges for effective diagnosis and treatment. Precisely engineered Ir and Mn cores within a single porphyrin framework of 4IrMn nanoparticles enable endogenous ONOO−‐ or laser‐activated switching among NIR‐CL imaging, photothermal / photodynamic therapy ...
Ziwei Wang, Liping Zhang, Zihan Wu, Nan Xiao, Wenxin Zheng, Yachao Wang, Gelin Xu, Dongxia Zhu, Martin R. Bryce, Lijie Ren, Ben Zhong Tang   +10 more
wiley   +1 more source

Sex Differences in rt-PA Utilization at Hospitals Treating Stroke: The National Inpatient Sample. [PDF]

, 2017
BACKGROUND AND PURPOSE: Sex and race disparities in recombinant tissue plasminogen activator (rt-PA) use have been reported. We sought to explore sex and race differences in the utilization of rt-PA at primary stroke centers (PSCs) compared to non-PSCs ...
Albright, Karen C, Boehme, Amelia K., Branas, Charles C., Carr, Brendan G., Elkind, Mitchell S V S.V., Kallan, Michael J., Kasner, Scott Eric, Mullen, Michael T.   +7 more
core   +2 more sources

“Time Is Brain” – for Cell Therapies

Advanced Science, EarlyView.
The concept that “time is brain” extends to stem cell therapy for stroke. Evidence across preclinical and clinical studies indicates that delivery timing shapes graft survival, integration, and efficacy by matching the evolving post‐stroke microenvironment.
Hao Yin, Dominikus Brian, Rebecca Z. Weber, Patrick D. Lyden, Ruslan Rust   +4 more
wiley   +1 more source

Predictive role of pre-thrombolytic hs-CRP on the safety and efficacy of intravenous thrombolysis in acute ischemic stroke

BMC Neurology, 2023
Purpose To investigate the predictive role of pre-thrombolytic high sensitivity C-reactive protein (hs-CRP) on the safety and efficacy of intravenous thrombolysis in patients with acute ischemic stroke (AIS).
Xu-Dong Cheng, Duo-Zi Wang, Qi Zhang, Jian-Hong Wang, Bing-Hu Li, Xin Zhang, Jing Zhang, Sen Zhou, Li-Jun Jia, Li-Rong Wang, Neng-Wei Yu   +10 more
doaj   +1 more source

Using Tenecteplase for Acute Ischemic Stroke: What Is the Hold Up? [PDF]

, 2020
Alteplase is the only Food and Drug Administration-approved intravenous (IV) thrombolytic medication for acute ischemic stroke. However, multiple recent studies comparing tenecteplase and alteplase suggest that tenecteplase is at least as efficacious as ...
Ataya, Ramsey, Brea, Isabel, Zitek, Tony
core  

CT perfusion as a selection tool for mechanical thrombectomy, a single-centre study [PDF]

, 2020
Background: Recently, CT perfusion (CTP) has been proposed as a selection tool for stroke patients to be treated with endovascular thrombectomy.
De Muynck, Emilie, Defreyne, Luc, Dhondt, Elisabeth, Hemelsoet, Dimitri, Huybrechts, Vincent, Vanlangenhove, Peter   +5 more
core   +1 more source