Results 1 to 10 of about 58,078 (149)

Feasibility of intravenous vitamin C supplementation in allogeneic hematopoietic cell transplant recipients [PDF]

eJHaem
Introduction Intravenous vitamin C was administered following hematopoietic stem cell transplant to mitigate nonrelapse mortality (NRM) in a Phase II clinical trial.
Gary L. Simmons, Roy Sabo, Rehan Qayyum, May Aziz, Erika Martin, Robyn J. Bernard, Manjari Sriparna, Cody McIntire, Elizabeth Krieger, Donald F. Brophy, Ramesh Natarajan, Alpha Fowler III, Catherine H. Roberts, Amir Toor   +13 more
doaj   +4 more sources

Intravenous vitamin C administration to patients with septic shock: a pilot randomised controlled trial [PDF]

Critical Care, 2022
Background Intravenous vitamin C administration in septic shock may have a sparing effect on vasopressor requirements, and vitamin C’s enzyme cofactor functions provide a mechanistic rationale.
Patrice Rosengrave, Emma Spencer, Jonathan Williman, Jan Mehrtens, Stacey Morgan, Tara Doyle, Kymbalee Van Der Heyden, Anna Morris, Geoff Shaw, Anitra C. Carr   +9 more
doaj   +2 more sources

Pharmacokinetic Evaluation of Intravenous Vitamin C: A Classic Pharmacokinetic Study. [PDF]

Clin Pharmacokinet, 2022
Intravenous vitamin C (IVC) is used in a variety of disorders with limited supporting pharmacokinetic data. Herein we report a pharmacokinetic study in healthy volunteers and cancer participants with IVC doses in the range of 1-100 g.A pharmacokinetic study was conducted in 21 healthy volunteers and 12 oncology participants.
Chen P, Reed G, Jiang J, Wang Y, Sunega J, Dong R, Ma Y, Esparham A, Ferrell R, Levine M, Drisko J, Chen Q.   +11 more
europepmc   +3 more sources

Intravenous Vitamin C for Patients Hospitalized With COVID-19: Two Harmonized Randomized Clinical Trials. [PDF]

JAMA, 2023
ImportanceThe efficacy of vitamin C for hospitalized patients with COVID-19 is uncertain.ObjectiveTo determine whether vitamin C improves outcomes for patients with COVID-19.Design, Setting, and ParticipantsTwo prospectively harmonized randomized clinical trials enrolled critically ill patients receiving organ support in intensive care units (90 sites)
LOVIT-COVID Investigators, on behalf of the Canadian Critical Care Trials Group, and the REMAP-CAP Investigators, Adhikari NKJ, Hashmi M, Tirupakuzhi Vijayaraghavan BK, Haniffa R, Beane A, Webb SA, Angus DC, Gordon AC, Cook DJ, Guyatt GH, Berry LR, Lorenzi E, Mouncey PR, Au C, Pinto R, Ménard J, Sprague S, Masse MH, Huang DT, Heyland DK, Nichol AD, McArthur CJ, de Man A, Al-Beidh F, Annane D, Anstey M, Arabi YM, Battista MC, Berry S, Bhimani Z, Bonten MJM, Bradbury CA, Brant EB, Brunkhorst FM, Burrell A, Buxton M, Cecconi M, Cheng AC, Cohen D, Cove ME, Day AG, Derde LPG, Detry MA, Estcourt LJ, Fagbodun EO, Fitzgerald M, Goossens H, Green C, Higgins AM, Hills TE, Horvat C, Ichihara N, Jayakumar D, Kanji S, Khoso MN, Lawler PR, Lewis RJ, Litton E, Marshall JC, McAuley DF, McGlothlin A, McGuinness SP, McQuilten ZK, McVerry BJ, Murthy S, Parke RL, Parker JC, Reyes LF, Rowan KM, Saito H, Salahuddin N, Santos MS, Saunders CT, Seymour CW, Shankar-Hari M, Tolppa T, Trapani T, Turgeon AF, Turner AM, Udy AA, van de Veerdonk FL, Zarychanski R, Lamontagne F.   +85 more
europepmc   +10 more sources

Effect of perioperative single dose intravenous vitamin C on pain after total hip arthroplasty [PDF]

Journal of Orthopaedic Surgery and Research
Introduction Vitamin c can relieve the pain after other diseases, but there are no studies on whether vitamin C can relieve the pain after hip replacement.
Guangtao Han, Yanfeng Gan, Qin Wang, Shuo Sun, Pengde Kang   +4 more
doaj   +2 more sources

Case report: The efficacy of adding high doses of intravenous vitamin C to the combination therapy of atezolizumab and bevacizumab in unresectable HCC [PDF]

Frontiers in Medicine
IntroductionVitamin C (L-ascorbic acid) plays a vital role in human physiology, serving as both an antioxidant and a cofactor in enzymatic reactions. High-dose intravenous Vitamin C can achieve significantly elevated plasma concentrations, potentially ...
Waleed Kian, Waleed Kian, Waleed Kian, Areen A. Remilah, Celine Shatat, Maria Spector, Laila C. Roisman, Larisa Ryvo   +7 more
doaj   +2 more sources

Low Vitamin C Concentrations in Patients with Community-Acquired Pneumonia Resolved with Pragmatic Administration of Intravenous and Oral Vitamin C

Antioxidants, 2023
Community-acquired pneumonia (CAP) is characterized by elevated markers of inflammation and oxidative stress and depleted circulating concentrations of the antioxidant nutrient vitamin C.
Anitra C. Carr, Emma Vlasiuk, Masuma Zawari, Amy Scott-Thomas, Malina Storer, Michael Maze, Stephen T. Chambers   +6 more
doaj   +3 more sources

Is intravenous vitamin C contraindicated in patients with G6PD deficiency? [PDF]

Critical Care, 2019
Paul E. Marik
doaj   +5 more sources

Efficacy of intravenous vitamin C in management of moderate and severe COVID-19: A double blind randomized placebo controlled trial [PDF]

Journal of Family Medicine and Primary Care, 2022
Aim: To study the efficacy of intravenous vitamin C in management of moderate and severe COVID-19. Objective: To determine the efficacy of intravenous vitamin C in reducing in-hospital mortality in moderate and severe cases of COVID-19. Design: Parallel,
Vijay Kumar, Divendu Bhushan, Sushmita Supriya, Avinash Aravind Ganapule, Pallavi Lohani, Shyama, Sanjay Pandey, Pramod Kumar Majhi, Utpal Anand, Ramesh Kumar, Umesh Kumar Bhadani   +10 more
doaj   +2 more sources

High-dose intravenous vitamin C attenuates hyperinflammation in severe coronavirus disease 2019. [PDF]

Nutrition, 2021
High-dose intravenous vitamin C (HIVC) is a major concern when treating patients with coronavirus disease 2019 (COVID-19). The aim of this study was to assess the clinical efficacy of HIVC on hyperinflammation in patients with severe COVID-19.This retrospective cohort study included hospitalized patients with severe COVID-19, a subset of whom was ...
Xia G, Fan D, He Y, Zhu Y, Zheng Q.
europepmc   +3 more sources