Results 231 to 240 of about 111,693 (253)
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Journal of Hepatology, 1985
Child-Turcotte classification (CTC) is an empirical but widely accepted approach for assessment of severity of cirrhosis. However, it is not known to what extent CTC reflects accurately the degree of impairment of hepatic function. In this study we compared CTC, standard liver tests and intrinsic hepatic clearance (IHC) of indocyanine green as means of
J C, Barbare +5 more
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Child-Turcotte classification (CTC) is an empirical but widely accepted approach for assessment of severity of cirrhosis. However, it is not known to what extent CTC reflects accurately the degree of impairment of hepatic function. In this study we compared CTC, standard liver tests and intrinsic hepatic clearance (IHC) of indocyanine green as means of
J C, Barbare +5 more
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Journal of Hepatology, 1989
The prognostic value of quantitative liver function tests in patients with cirrhosis is not clearly established. Indocyanine green intrinsic hepatic clearance (ICG-IHC) is a quantitative liver function parameter independent of liver blood flow, which was shown to correlate strictly with the Child-Turcotte-Pugh (CTP) classification of severity of liver ...
MERKEL, CARLO +6 more
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The prognostic value of quantitative liver function tests in patients with cirrhosis is not clearly established. Indocyanine green intrinsic hepatic clearance (ICG-IHC) is a quantitative liver function parameter independent of liver blood flow, which was shown to correlate strictly with the Child-Turcotte-Pugh (CTP) classification of severity of liver ...
MERKEL, CARLO +6 more
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In Silico Categorization of in Vivo Intrinsic Clearance Using Machine Learning
Molecular Pharmaceutics, 2013Machine learning has recently become popular and much used within the life science research domain, e.g., for finding quantitative structure-activity relationships (QSARs) between molecular structures and different biological end points. In the work presented here, we have applied orthogonal partial least-squares (OPLS), principal component analysis ...
Ya-Wen, Hsiao +2 more
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Environmental Science & Technology, 2016
The use of trophic magnification factors (TMFs) to characterize the bioaccumulation potentials of chemicals was encouraged; however, the method for the assessment of trophic magnification potentials is still lacking. We optimized the in vitro assays used for the measurement of intrinsic clearance in liver microsomes by incorporating benzo[a]pyrene (B(a)
Zheng, Guomao, Wan, Yi, Hu, Jianying
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The use of trophic magnification factors (TMFs) to characterize the bioaccumulation potentials of chemicals was encouraged; however, the method for the assessment of trophic magnification potentials is still lacking. We optimized the in vitro assays used for the measurement of intrinsic clearance in liver microsomes by incorporating benzo[a]pyrene (B(a)
Zheng, Guomao, Wan, Yi, Hu, Jianying
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Clearly There is Intrinsic Value in Intrinsic Clearance
Hepatology, 1983R K, Roberts, S, Schenker
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Drug Metabolism and Disposition
Several reports in the scientific literature characterize cytosolic aldehyde oxidase (AO) contamination in commercially available human liver microsomal preparations; however, the precise ramifications of residual AO activity on pharmacokinetic predictions remains unclear.
Lloyd Wei Tat Tang, R. Scott Obach
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Several reports in the scientific literature characterize cytosolic aldehyde oxidase (AO) contamination in commercially available human liver microsomal preparations; however, the precise ramifications of residual AO activity on pharmacokinetic predictions remains unclear.
Lloyd Wei Tat Tang, R. Scott Obach
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CLEARANCE AND BIOLOGIC HALF-LIFE AS INDICES OF INTRINSIC HEPATIC METABOLISM
The Journal of Pharmacology and Experimental Therapeutics, 1974D, Perrier, M, Gibaldi
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