Results 241 to 250 of about 111,693 (253)

Kinetics of In Vitro Metabolism: Assimilation of Intrinsic Clearance in Hepatic Clearance

2015
openaire   +1 more source

Application of a low intrinsic clearance assay in preclinical drug discovery

Drug Metabolism and Pharmacokinetics, 2018
Beth Williamson, Paul Lancett, Mathias Lorbeer, Robert Riley, Patrick Barton   +4 more
openaire   +1 more source

Interspecies variation in liver weight, hepatic blood flow, and antipyrine intrinsic clearance: Extrapolation of data to benzodiazepines and phenytoin

Journal of Pharmacokinetics and Pharmacodynamics, 1980
Harold Boxenbaum, H Boxenbaum
exaly  

Quantitative Property–Property Relationship for Screening-Level Prediction of Intrinsic Clearance: A Tool for Exposure Modeling for High-Throughput Toxicity Screening Data

Applied in Vitro Toxicology, 2015
Olivier Jolliet, Russell Thomas, Barbara Wetmore   +2 more
exaly  

Three-Dimensional Quantitative Structure Activity Relationship Computational Approaches for Prediction of Human In Vitro Intrinsic Clearance

Journal of Pharmacology and Experimental Therapeutics, 2000
Sean Ekins, R Scott Obach
exaly  

Comparison of predicted intrinsic hepatic clearance of 30 pharmaceuticals in canine and feline liver microsomes

Xenobiotica, 2019
Marike Visser, Dawn M Boothe
exaly  

Intrinsic clearance rate of O-desmethyltramadol (M1) by glucuronide conjugation and phase I metabolism by feline, canine and common brush-tailed possum microsomes

Xenobiotica, 2020
Merran Govendir
exaly  

In vitro-in vivo correlation for intrinsic clearance for CP-409,092 and sumatriptan: a case study to predict the in vivo clearance for compounds metabolized by monoamine oxidase

Xenobiotica, 2012
Kevin Colizza, R Scott Obach
exaly  

Prediction of the in vitro intrinsic clearance determined in suspensions of human hepatocytes by using artificial neural networks

European Journal of Pharmaceutical Sciences, 2010
Luis Gouveia, Paulo Paixao, JOSÉ A G Morais   +2 more
exaly  

Vector form intrinsic finite element method for planar multibody systems with multiple clearance joints

Nonlinear Dynamics, 2016
Renjie Pan, Tuqiao Zhang, Zhang Tuqiao   +2 more
exaly