Results 61 to 70 of about 1,836,928 (287)

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

A Uniform Correlation between Synchrotron Luminosity and Doppler Factor in Gamma-ray Bursts and Blazars: hint of similar intrinsic luminosities?

, 2011
We compile 23 Gamma-ray Bursts (GRBs) and 21 blazars with estimated Doppler factors, and the Doppler factors of GRBs are estimated from their Lorentz factors by assuming their jet viewing angles \theta->0 degree.
Abdo, Butler, Butler, Eichler, Fenimore, Ghirlanda, Ghirlanda, Liang, Liang, Lu, Lähteenmäki, Mészáros, Paciesas, Pe'er, Pe'er, Reichart, Sari, Wang, Wu, Yonetoku, Zhang, Zou   +21 more
core   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

High Quality Factor Silicon Cantilever Driven by PZT Actuator for Resonant Based Mass Detection [PDF]

, 2008
A high quality factor (Q-factor) piezoelectric lead zirconat titanate (PZT) actuated single crystal silicon cantilever was proposed in this paper for resonant based ultra-sensitive mass detection.
Ikehara, T., Itoh, Toshihiro, Lu, Jian, Maeda, Ryutaro, Mihara, Takashi, Zhang, Yi   +5 more
core   +1 more source

Accurate photometry of extended spherically symmetric sources

, 2006
We present a new method to derive reliable photometry of extended spherically symmetric sources from {\it HST} images (WFPC2, ACS/WFC and NICMOS/NIC2 cameras), extending existing studies of point sources and marginally resolved sources.
Boeker, Carlson, Carlson, de Grijs, Dolphin, Dolphin, Elson, Holtzman, King, Larsen, Larsen, M. Gieles, Mackey, Mackey, Miller, P. Anders, Puzia, R. de Grijs, Whitmore, Whitmore, Zepf   +20 more
core   +1 more source

A master surgical educator: the "intrinsic" factor of Dr. Paul Greig. [PDF]

HPB (Oxford), 2022
Al-Adra DP, Barbas AS, Shah S, Molinari M.   +3 more
europepmc   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Exploring the Association of Helicobacter pylori With Anti-intrinsic Factor and Anti-parietal Cell Antibodies in Pernicious Anemia: A Systematic Review. [PDF]

Cureus, 2023
Allakky A.
europepmc   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Bright end of the luminosity function of high-mass X-ray binaries: contributions of hard, soft and supersoft sources

, 2016
Using a spectral analysis of bright Chandra X-ray sources located in 27 nearby galaxies and maps of star-formation rate (SFR) and ISM surface densities for these galaxies, we constructed the intrinsic X-ray luminosity function (XLF) of luminous high-mass
Khabibullin, Ildar, Sazonov, Sergey
core   +1 more source