Results 61 to 70 of about 215,660 (296)
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Jixie qiangdu, 2023 The data-driven intelligent diagnosis of rolling bearing status suffers from low recognition rate due to the poor quality of learning samples in the process of identification model construction.
QIN Bo +6 more
doaj
Intelligent fault diagnosis of rotating machinery based on deep learning with feature selection
Journal of Low Frequency Noise, Vibration and Active Control, 2020 In the absence of a priori knowledge, manual feature selection is too blind to find the sensitive features which can effectively classify the different fault features.
Dongying Han, Kai Liang, Peiming Shi
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Time delay estimation based on variational mode decomposition
Advances in Mechanical Engineering, 2017 In order to improve the time delay estimation of colored noise signals, this article proposes generalized cross-correlation time delay estimation based on variational mode decomposition.
Jing-Yi Lu, Dong Ye, Wen-Ping Ma
doaj +1 more source
From mode choice to modal diversion: A new behavioural paradigm and an application to the study of the demand for innovative transport services [PDF]
, 2009 We analyse past research efforts that focus on modal diversion in the transport sector, as opposed to the classical mode choice concept, showing the added value of this alternative framework that emerges from the existing scientific literature. The modal
Marco Diana, Diana, Marco
core +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Study on the orientation detection of surface cracks by electromagnetic acoustic emission
International Journal of Distributed Sensor Networks, 2019 Crack orientation plays a vital role in structural integrity analysis, which provides quantitative crack growth and structural failure information. Even though many structural health monitoring systems can detect crack location and length, only few ...
Zhichao Cai
doaj +1 more source
Structural Dynamics and Allosteric Signaling in Ionotropic Glutamate Receptors [PDF]
, 2013 Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that mediate excitatory neurotransmission events in the central nervous system. All distinct classes of iGluRs (AMPA, NMDA, Kainate) are composed of an N-terminal domain (NTD) and a ...
Dutta, Anindita
core