Results 21 to 30 of about 3,579,241 (217)

Intrinsic disorder in the open reading frame 2 of hepatitis E virus: a protein with multiple functions beyond viral capsid

Journal of Genetic Engineering and Biotechnology, 2023
Background Hepatitis E virus (HEV) is the cause of a liver disease hepatitis E. The translation product of HEV ORF2 has recently been demonstrated as a protein involved in multiple functions besides performing its major role of a viral capsid.
Zoya Shafat, Anwar Ahmed, Mohammad K. Parvez, Shama Parveen   +3 more
doaj   +1 more source

How multisite phosphorylation impacts the conformations of intrinsically disordered proteins.

PLoS Computational Biology, 2021
Phosphorylation of intrinsically disordered proteins (IDPs) can produce changes in structural and dynamical properties and thereby mediate critical biological functions.
Fan Jin, Frauke Gräter
doaj   +1 more source

Folding factors and partners for the intrinsically disordered protein Micro-Exon Gene 14 (MEG-14) [PDF]

, 2013
The micro-exon genes (MEG) of Schistosoma mansoni, a parasite responsible for the second most widely spread tropical disease, code for small secreted proteins with sequences unique to the Schistosoma genera.
Orcia, Debora, Araujo, A.P.U., Wallace, Bonnie A., Araújo, Ana Paula Ulian de, De Marco, Ricardo, Araujo, Ana Paula U., Debora Orcia, Wallace, B. A., Lopes, Jose Luiz S., DeMarco, Ricardo, Lopes, J.L.S., Ricardo DeMarco, Ana Paula U. Araujo, Orcia, D., B.A. Wallace, Wallace, B.A., Jose Luiz S. Lopes, DeMarco, R.   +17 more
core   +1 more source

Biophysical and Structural Study of Intrinsically Disordered Protein (IDP), Nopp140 [PDF]

Biophysical Journal, 2013
Human Nopp140 is a highly phosphorylated nucleolus protein and involved in the biogenesis of the nucleolus. It interacts with a variety of proteins related to the synthesis and assembly of the ribosome including a ubiquitous protein kinase CK2 which mediates cell growth and prevents apoptosis.
Na, Jung-Hyun, Lee, Won-Kyu, Soo Song, Seung, Jeong, Cherlhyun, Gyu Yu, Yeon   +4 more
openaire   +1 more source

An intrinsically disordered proteins community for ELIXIR [version 1; peer review: 2 approved]

F1000Research, 2019
Intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) are now recognised as major determinants in cellular regulation.
Norman E. Davey, M. Madan Babu, Martin Blackledge, Alan Bridge, Salvador Capella-Gutierrez, Zsuzsanna Dosztanyi, Rachel Drysdale, Richard J. Edwards, Arne Elofsson, Isabella C. Felli, Toby J. Gibson, Aleksandras Gutmanas, John M. Hancock, Jen Harrow, Desmond Higgins, Cy M. Jeffries, Philippe Le Mercier, Balint Mészáros, Marco Necci, Cedric Notredame, Sandra Orchard, Christos A. Ouzounis, Rita Pancsa, Elena Papaleo, Roberta Pierattelli, Damiano Piovesan, Vasilis J. Promponas, Patrick Ruch, Gabriella Rustici, Pedro Romero, Sirarat Sarntivijai, Gary Saunders, Benjamin Schuler, Malvika Sharan, Denis C. Shields, Joel L. Sussman, Jonathan A. Tedds, Peter Tompa, Michael Turewicz, Jiri Vondrasek, Wim F. Vranken, Bonnie Ann Wallace, Kanin Wichapong, Silvio C. E. Tosatto   +43 more
doaj   +1 more source

Physicochemical Properties of Cells and Their Effects on Intrinsically Disordered Proteins (IDPs)

Chemical Reviews, 2014
It has long been axiomatic that a protein’s structure determines its function. Intrinsically disordered proteins (IDPs) and disordered protein regions (IDRs) defy this structure–function paradigm. They do not exhibit stable secondary and/or tertiary structures and exist as dynamic ensembles of interconverting conformers with preferred, nonrandom ...
Theillet, Francois-Xavier, Binolfi, Andres, Frembgen-Kesner, Tamara, Hingorani, Karan, Sarkar, Mohona, Kyne, Ciara, Li, Conggang, Crowley, Peter B., Gierasch, Lila, Pielak, Gary J., Elcock, Adrian H., Gershenson, Anne, Selenko, Philipp   +12 more
openaire   +2 more sources

Preparation of Bioderived and Biodegradable Surfactants Based on an Intrinsically Disordered Protein Sequence [PDF]

, 2021
Surfactants, block-copolymers, and other types of micellar systems are used in a wide variety of biomedical and industrial processes. However, most commonly used surfactants are synthetically derived and pose environmental and toxicological concerns ...
Matthew, Francis, Anthony, Omole, Bibiana, Onoa, Carlos, Bustamante, Sarah, Klass, Jamie, Gleason   +5 more
core   +2 more sources

Identification of Intrinsically Disordered Proteins and Regions by Length-Dependent Predictors Based on Conditional Random Fields

Molecular Therapy: Nucleic Acids, 2019
Accurate identification of intrinsically disordered proteins/regions (IDPs/IDRs) is critical for predicting protein structure and function. Previous studies have shown that IDRs of different lengths have different characteristics, and several ...
Yumeng Liu, Shengyu Chen, Xiaolong Wang, Bin Liu   +3 more
doaj   +1 more source

Intrinsically disordered proteins: modes of binding with emphasis on disordered domains

Open Biology, 2021
Our notions of protein function have long been determined by the protein structure–function paradigm. However, the idea that protein function is dictated by a prerequisite complementarity of shapes at the binding interface is becoming increasingly ...
Owen Michael Morris, James Hilary Torpey, Rivka Leah Isaacson   +2 more
doaj   +1 more source

DMFpred: Predicting protein disorder molecular functions based on protein cubic language model.

PLoS Computational Biology, 2022
Intrinsically disordered proteins and regions (IDP/IDRs) are widespread in living organisms and perform various essential molecular functions. These functions are summarized as six general categories, including entropic chain, assembler, scavenger ...
Yihe Pang, Bin Liu
doaj   +1 more source