Results 21 to 30 of about 4,606,382 (149)

Intrinsically disordered proteins (IDPs) in trypanosomatids [PDF]

BMC Genomics, 2014
Proteins are composed of one or more amino acid chains and exhibit several structure levels. IDPs (intrinsically disordered proteins) represent a class of proteins that do not fold into any particular conformation and exist as dynamic ensembles in their native state.
Ruy, Patrícia, Torrieri, Raul, Toledo, Juliano, Alves, Viviane, Cruz, Angela, Ruiz, Jeronimo   +5 more
openaire   +2 more sources

Identification of ligand binding sites in intrinsically disordered proteins with a differential binding score

Scientific Reports, 2021
Screening ligands directly binding to an ensemble of intrinsically disordered proteins (IDP) to discover potential hits or leads for new drugs is an emerging but challenging area as IDPs lack well-defined and ordered 3D-protein structures.
Qiao-Hong Chen, V. V. Krishnan
doaj   +1 more source

Identification of Intrinsically Disordered Proteins and Regions in a Non-Model Insect Species Ostrinia nubilalis (Hbn.)

Biomolecules, 2022
Research in previous decades has shown that intrinsically disordered proteins (IDPs) and regions in proteins (IDRs) are as ubiquitous as highly ordered proteins. Despite this, research on IDPs and IDRs still has many gaps left to fill.
Miloš Avramov, Éva Schád, Ágnes Révész, Lilla Turiák, Iva Uzelac, Ágnes Tantos, László Drahos, Željko D. Popović   +7 more
doaj   +1 more source

Structural Analysis of Intrinsically Disordered Protein (IDP): TRIOBP [PDF]

Biophysical Journal, 2014
TRIOBP is an actin-bundling protein. Mutations of TRIOBP are associated with human deafness DFNB28. TRIOBP has three isoforms, named TRIOBP-1, TRIOBP-4, and TRIOBP-5. In vitro, TRIOBP isoform 4 (TRIOBP-4) forms dense F-actin bundles resembling the inner ear hair cell rootlet structure.
Gunther, Laura K., Bao, Jianjun, Thirumurugan, Kavitha, Kitajiri, Shin-ichiro, Sakamoto, Takeshi   +4 more
openaire   +1 more source

Unraveling the Thermodynamics of Ultra-tight Binding of Intrinsically Disordered Proteins

Frontiers in Molecular Biosciences, 2021
Protein interactions mediated by the intrinsically disordered proteins (IDPs) are generally associated with lower affinities compared to those between globular proteins.
Uroš Zavrtanik, San Hadži, Jurij Lah
doaj   +1 more source

Intrinsic disorder in the open reading frame 2 of hepatitis E virus: a protein with multiple functions beyond viral capsid

Journal of Genetic Engineering and Biotechnology, 2023
Background Hepatitis E virus (HEV) is the cause of a liver disease hepatitis E. The translation product of HEV ORF2 has recently been demonstrated as a protein involved in multiple functions besides performing its major role of a viral capsid.
Zoya Shafat, Anwar Ahmed, Mohammad K. Parvez, Shama Parveen   +3 more
doaj   +1 more source

Preparation of Bioderived and Biodegradable Surfactants Based on an Intrinsically Disordered Protein Sequence [PDF]

, 2021
Surfactants, block-copolymers, and other types of micellar systems are used in a wide variety of biomedical and industrial processes. However, most commonly used surfactants are synthetically derived and pose environmental and toxicological concerns ...
Matthew, Francis, Anthony, Omole, Bibiana, Onoa, Carlos, Bustamante, Sarah, Klass, Jamie, Gleason   +5 more
core   +2 more sources

How multisite phosphorylation impacts the conformations of intrinsically disordered proteins.

PLoS Computational Biology, 2021
Phosphorylation of intrinsically disordered proteins (IDPs) can produce changes in structural and dynamical properties and thereby mediate critical biological functions.
Fan Jin, Frauke Gräter
doaj   +1 more source

Folding factors and partners for the intrinsically disordered protein Micro-Exon Gene 14 (MEG-14) [PDF]

, 2013
The micro-exon genes (MEG) of Schistosoma mansoni, a parasite responsible for the second most widely spread tropical disease, code for small secreted proteins with sequences unique to the Schistosoma genera.
Orcia, Debora, Araujo, A.P.U., Wallace, Bonnie A., Araújo, Ana Paula Ulian de, De Marco, Ricardo, Debora Orcia, Wallace, B. A., Lopes, Jose Luiz S., Lopes, J.L.S., Ricardo DeMarco, Ana Paula U. Araujo, Orcia, D., B.A. Wallace, Jose Luiz S. Lopes, DeMarco, R.   +14 more
core   +1 more source

An intrinsically disordered proteins community for ELIXIR [version 1; peer review: 2 approved]

F1000Research, 2019
Intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) are now recognised as major determinants in cellular regulation.
Norman E. Davey, M. Madan Babu, Martin Blackledge, Alan Bridge, Salvador Capella-Gutierrez, Zsuzsanna Dosztanyi, Rachel Drysdale, Richard J. Edwards, Arne Elofsson, Isabella C. Felli, Toby J. Gibson, Aleksandras Gutmanas, John M. Hancock, Jen Harrow, Desmond Higgins, Cy M. Jeffries, Philippe Le Mercier, Balint Mészáros, Marco Necci, Cedric Notredame, Sandra Orchard, Christos A. Ouzounis, Rita Pancsa, Elena Papaleo, Roberta Pierattelli, Damiano Piovesan, Vasilis J. Promponas, Patrick Ruch, Gabriella Rustici, Pedro Romero, Sirarat Sarntivijai, Gary Saunders, Benjamin Schuler, Malvika Sharan, Denis C. Shields, Joel L. Sussman, Jonathan A. Tedds, Peter Tompa, Michael Turewicz, Jiri Vondrasek, Wim F. Vranken, Bonnie Ann Wallace, Kanin Wichapong, Silvio C. E. Tosatto   +43 more
doaj   +1 more source