Results 31 to 40 of about 5,123 (214)

Preparation of Bioderived and Biodegradable Surfactants Based on an Intrinsically Disordered Protein Sequence

, 2021
Surfactants, block-copolymers, and other types of micellar systems are used in a wide variety of biomedical and industrial processes. However, most commonly used surfactants are synthetically derived and pose environmental and toxicological concerns ...
Matthew, Francis, Anthony, Omole, Bibiana, Onoa, Carlos, Bustamante, Sarah, Klass, Jamie, Gleason   +5 more
core   +1 more source

An intrinsically disordered proteins community for ELIXIR [version 1; peer review: 2 approved]

F1000Research, 2019
Intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) are now recognised as major determinants in cellular regulation.
Norman E. Davey, M. Madan Babu, Martin Blackledge, Alan Bridge, Salvador Capella-Gutierrez, Zsuzsanna Dosztanyi, Rachel Drysdale, Richard J. Edwards, Arne Elofsson, Isabella C. Felli, Toby J. Gibson, Aleksandras Gutmanas, John M. Hancock, Jen Harrow, Desmond Higgins, Cy M. Jeffries, Philippe Le Mercier, Balint Mészáros, Marco Necci, Cedric Notredame, Sandra Orchard, Christos A. Ouzounis, Rita Pancsa, Elena Papaleo, Roberta Pierattelli, Damiano Piovesan, Vasilis J. Promponas, Patrick Ruch, Gabriella Rustici, Pedro Romero, Sirarat Sarntivijai, Gary Saunders, Benjamin Schuler, Malvika Sharan, Denis C. Shields, Joel L. Sussman, Jonathan A. Tedds, Peter Tompa, Michael Turewicz, Jiri Vondrasek, Wim F. Vranken, Bonnie Ann Wallace, Kanin Wichapong, Silvio C. E. Tosatto   +43 more
doaj   +1 more source

Physicochemical Properties of Cells and Their Effects on Intrinsically Disordered Proteins (IDPs)

Chemical Reviews, 2014
It has long been axiomatic that a protein’s structure determines its function. Intrinsically disordered proteins (IDPs) and disordered protein regions (IDRs) defy this structure–function paradigm. They do not exhibit stable secondary and/or tertiary structures and exist as dynamic ensembles of interconverting conformers with preferred, nonrandom ...
Theillet, Francois-Xavier, Binolfi, Andres, Frembgen-Kesner, Tamara, Hingorani, Karan, Sarkar, Mohona, Kyne, Ciara, Li, Conggang, Crowley, Peter B., Gierasch, Lila, Pielak, Gary J., Elcock, Adrian H., Gershenson, Anne, Selenko, Philipp   +12 more
openaire   +2 more sources

Biophysical and Structural Study of Intrinsically Disordered Protein (IDP), Nopp140 [PDF]

Biophysical Journal, 2013
Human Nopp140 is a highly phosphorylated nucleolus protein and involved in the biogenesis of the nucleolus. It interacts with a variety of proteins related to the synthesis and assembly of the ribosome including a ubiquitous protein kinase CK2 which mediates cell growth and prevents apoptosis.
Na, Jung-Hyun, Lee, Won-Kyu, Soo Song, Seung, Jeong, Cherlhyun, Gyu Yu, Yeon   +4 more
openaire   +1 more source

Identification of Intrinsically Disordered Proteins and Regions by Length-Dependent Predictors Based on Conditional Random Fields

Molecular Therapy: Nucleic Acids, 2019
Accurate identification of intrinsically disordered proteins/regions (IDPs/IDRs) is critical for predicting protein structure and function. Previous studies have shown that IDRs of different lengths have different characteristics, and several ...
Yumeng Liu, Shengyu Chen, Xiaolong Wang, Bin Liu   +3 more
doaj   +1 more source

Intrinsically disordered proteins: modes of binding with emphasis on disordered domains

Open Biology, 2021
Our notions of protein function have long been determined by the protein structure–function paradigm. However, the idea that protein function is dictated by a prerequisite complementarity of shapes at the binding interface is becoming increasingly ...
Owen Michael Morris, James Hilary Torpey, Rivka Leah Isaacson   +2 more
doaj   +1 more source

DMFpred: Predicting protein disorder molecular functions based on protein cubic language model.

PLoS Computational Biology, 2022
Intrinsically disordered proteins and regions (IDP/IDRs) are widespread in living organisms and perform various essential molecular functions. These functions are summarized as six general categories, including entropic chain, assembler, scavenger ...
Yihe Pang, Bin Liu
doaj   +1 more source

Long-range structural preformation in yes-associated protein precedes encounter complex formation with TEAD

iScience, 2022
Summary: Yes-associated protein (YAP) is a partly intrinsically disordered protein (IDP) that plays a major role as the downstream element of the Hippo pathway.
Michael Feichtinger, Andreas Beier, Mario Migotti, Matthias Schmid, Fedir Bokhovchuk, Patrick Chène, Robert Konrat   +6 more
doaj   +1 more source

Unreported intrinsic disorder in proteins: Building connections to the literature on IDPs [PDF]

Intrinsically Disordered Proteins, 2014
This review opens a new series entitled "Unreported intrinsic disorder in proteins." The goal of this series is to bring attention of researchers to an interesting phenomenon of missed (or overlooked, or ignored, or unreported) disorder. This series serves as a companion to "Digested Disorder" which provides a quarterly review of papers on ...
openaire   +3 more sources

Accurate and Fast Prediction of Intrinsically Disordered Protein by Multiple Protein Language Models and Ensemble Learning

, 2023
Intrinsically disordered proteins (IDPs) play a vital role in various biological processes and have attracted increasing attention in the past few decades. Predicting IDPs from the primary structures of proteins offers a rapid and facile means of protein
Akira Onoda, Akira Onoda (1470163), Shijie Xu, Shijie Xu (3324546)   +3 more
core   +1 more source