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Molecular Bases of Salinity Resistance via Intrinsic Disordered Protein (IDP)

2023
Salt-affected soil is a prominent challenge in agriculture. Nowadays, more than 800 million hectares of land (about 6% of the world’s total land area) are induced with high salt concentrations, and thus, are unsuitable for growing typically salt-sensitive crop plants. The ongoing salinization of arable land exacerbates this limitation.
openaire   +2 more sources

Intrinsically disordered proteins (IDPs) studied by EPR and in-cell EPR

2018
Intrinsically disordered proteins (IDPs) play important physiological, but also disease-related roles. In order to understand the function and malfunction of proteins of this class, electron paramagnetic resonance (EPR) spectroscopy has proven to be a valuable tool, allowing investigation of the protein structural ensembles upon interaction with the ...
Sabrina Weickert   +2 more
openaire   +1 more source

A multi-responsive intrinsically disordered protein (IDP)-directed green synthesis of fluorescent gold nanoclusters

Journal of Materials Chemistry B, 2015
Herein we demonstrate the green synthesis of fluorescent gold nanoclusters (AuNCs) using a multi-responsive intrinsically disordered protein (IDP) polymer, Rec1-resilin, as a multi-functional template.
Balu, R.   +5 more
openaire   +5 more sources

Unusual biophysics of intrinsically disordered proteins

open access: yesBiochimica Et Biophysica Acta - Proteins and Proteomics, 2013
Research of a past decade and a half leaves no doubt that complete understanding of protein functionality requires close consideration of the fact that many functional proteins do not have well-folded structures.
Vladimir Uversky
exaly   +2 more sources

Exclusively Heteronuclear 13C‐Detected Amino‐Acid‐Selective NMR Experiments for the Study of Intrinsically Disordered Proteins (IDPs)

ChemBioChem, 2012
AbstractCarbon‐13 direct‐detection NMR methods have proved to be very useful for the characterization of intrinsically disordered proteins (IDPs). Here we present a suite of experiments in which amino‐acid‐selective editing blocks are encoded in CACON‐ and CANCO‐type sequences to give 13C‐detected spectra containing correlations arising from a ...
W. Bermel   +6 more
openaire   +3 more sources

The gene expression profiling of hepatocellular carcinoma by a network analysis approach shows a dominance of intrinsically disordered proteins (IDPs) between hub nodes

Molecular BioSystems, 2015
Abstract We have analyzed the transcriptomic data from patients with hepatocellular carcinoma (HCC) after viral HCV infection at the various stages of the disease by means of a networking analysis using the publicly available E-MTAB-950 dataset.
Singh S   +6 more
openaire   +2 more sources

IDP-T5CKNN: Protein Language Models for Prediction of Intrinsically Disordered Proteins

Current Computer Science
Introduction: Disordered proteins (IDPs) and disordered protein regions (IDRs) have important roles in cellular signalling and regulation and in disease development. However, their flexible conformations create challenges in annotating them through computational methods.
openaire   +1 more source

Perspectives on evolutionary and functional importance of intrinsically disordered proteins

International Journal of Biological Macromolecules, 2023
Vikash Dubey, Debanjan Kundu
exaly  

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