Results 41 to 50 of about 32,259 (261)
Benchmarking of force fields to characterize the intrinsically disordered R2-FUS-LC region
Scientific Reports, 2023 Intrinsically Disordered Proteins (IDPs) play crucial roles in numerous diseases like Alzheimer's and ALS by forming irreversible amyloid fibrils. The effectiveness of force fields (FFs) developed for globular proteins and their modified versions for ...
Maud Chan-Yao-Chong +2 more
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Biomolecules, 2021 Many proteins contain intrinsically disordered regions (IDRs) which carry out important functions without relying on a single well-defined conformation.
Bálint Mészáros +3 more
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Functions of Intrinsically Disordered Regions
BiologyIntrinsically disordered regions (IDRs), defined as protein segments lacking stable tertiary structures, are ubiquitously present in the human proteome and enriched with disease-associated mutations. IDRs harbor molecular recognition features (MoRFs) and post-translational modification sites (e.g., phosphorylation), enabling dynamic intermolecular ...
Linhu Xiao, Kun Xia
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Many-to-one binding by intrinsically disordered protein regions
Biocomputing 2020, 2019 Disordered binding regions (DBRs), which are embedded within intrinsically disordered proteins or regions (IDPs or IDRs), enable IDPs or IDRs to mediate multiple protein-protein interactions. DBR-protein complexes were collected from the Protein Data Bank for which two or more DBRs having different amino acid sequences bind to the same (100% sequence ...
Alterovitz, Wei-Lun +9 more
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Phosphorylation in intrinsically disordered regions regulates the activity of Neurogenin2 [PDF]
BMC Biochemistry, 2014 Neuronal differentiation is largely under the control of basic Helix-Loop-Helix (bHLH) proneural transcription factors that play key roles during development of the embryonic nervous system. In addition to well-characterised regulation of their expression, increasing evidence is emerging for additional post-translational regulation of proneural protein
Mcdowell, Gary S +4 more
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Haematologica, 2019 As high fetal hemoglobin levels ameliorate the underlying pathophysiological defects in sickle cell anemia and beta (β)-thalassemia, understanding the mechanisms that enforce silencing of fetal hemoglobin postnatally offers the promise of effective ...
Xiaofei Yu +8 more
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MembranesAutophagy is a carefully regulated catabolic process that utilizes assemblies of specific sets of macromolecules operating at multiple stages of the pathway.
Vladimir N. Uversky +2 more
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Nature Communications, 2022 Here the authors demonstrate that TGFβ drives multi-enhancer contacts and ultimately gene activation during neuronal commitment, and that this requires the intrinsically disordered region (IDR) of the histone demethylase JMJD3 likely through its role in ...
Marta Vicioso-Mantis +7 more
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Fuzzy recognition by the prokaryotic transcription factor HigA2 from Vibrio cholerae
Nature CommunicationsDisordered protein sequences can exhibit different binding modes, ranging from well-ordered folding-upon-binding to highly dynamic fuzzy binding. The primary function of the intrinsically disordered region of the antitoxin HigA2 from Vibrio cholerae is ...
San Hadži +9 more
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Journal of Genetic Engineering and Biotechnology, 2023 Background Hepatitis E virus (HEV) is the cause of a liver disease hepatitis E. The translation product of HEV ORF2 has recently been demonstrated as a protein involved in multiple functions besides performing its major role of a viral capsid.
Zoya Shafat +3 more
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