Entropy and Information within Intrinsically Disordered Protein Regions [PDF]
Entropy, 2019 Bioinformatics and biophysical studies of intrinsically disordered proteins and regions (IDRs) note the high entropy at individual sequence positions and in conformations sampled in solution. This prevents application of the canonical sequence-structure-function paradigm to IDRs and motivates the development of new methods to extract information from ...
Iva Pritisanac +3 more
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DisoMCS: Accurately Predicting Protein Intrinsically Disordered Regions Using a Multi-Class Conservative Score Approach. [PDF]
PLoS ONE, 2015 The precise prediction of protein intrinsically disordered regions, which play a crucial role in biological procedures, is a necessary prerequisite to further the understanding of the principles and mechanisms of protein function.
Zhiheng Wang +3 more
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The intrinsically disordered region of coronins fine-tunes oligomerization and actin polymerization
Cell Reports, 2023 Summary: Coronins play critical roles in actin network formation. The diverse functions of coronins are regulated by the structured N-terminal β propeller and the C-terminal coiled coil (CC).
Xiao Han +8 more
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Intrinsic Disorder in Proteins with Pathogenic Repeat Expansions
Molecules, 2017 Intrinsically disordered proteins and proteins with intrinsically disordered regions have been shown to be highly prevalent in disease. Furthermore, disease-causing expansions of the regions containing tandem amino acid repeats often push repetitive ...
April L. Darling, Vladimir N. Uversky
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Cell Communication and Signaling, 2020 The serine/threonine phosphatase calcineurin acts as a crucial connection between calcium signaling the phosphorylation states of numerous important substrates.
Trevor P. Creamer
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Analysis of structured and intrinsically disordered regions of transmembrane proteins [PDF]
Molecular BioSystems, 2009 Abstract Integral membraneproteins display two major types of transmembrane structure, helical bundles and beta barrels. The main functional roles of transmembrane proteins are the transport of small molecules and cellsignaling, and sometimes these two roles are coupled.
Xue, Bin +4 more
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Regulation of Src tumor activity by its N-terminal intrinsically disordered region
, 2022 The membrane-anchored Src tyrosine kinase is involved in numerous pathways and its deregulation is involved in human cancer. Our knowledge on Src regulation relies on crystallography, which revealed intramolecular interactions to control active Src ...
Fort, Philippe +13 more
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Physicochemical characterisation of KEIF€-the intrinsically disordered N-terminal region of magnesium transporter A [Elektronisk resurs] [PDF]
, 2020 Magnesium transporter A (MgtA) is an active transporter responsible for importing magnesium ions into the cytoplasm of prokaryotic cells. This study focuses on the peptide corresponding to the intrinsically disordered N-terminal region of MgtA, referred ...
Jephthah, Stéphanie, +5 more
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Benchmarking of force fields to characterize the intrinsically disordered R2-FUS-LC region
Scientific Reports, 2023 Intrinsically Disordered Proteins (IDPs) play crucial roles in numerous diseases like Alzheimer's and ALS by forming irreversible amyloid fibrils. The effectiveness of force fields (FFs) developed for globular proteins and their modified versions for ...
Maud Chan-Yao-Chong +2 more
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Biomolecules, 2021 Many proteins contain intrinsically disordered regions (IDRs) which carry out important functions without relying on a single well-defined conformation.
Bálint Mészáros +3 more
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