Results 21 to 30 of about 32,259 (261)
The tail of cryptochromes: an intrinsically disordered cog within the mammalian circadian clock
Cell Communication and Signaling, 2020 Cryptochrome (CRY) proteins play an essential role in regulating mammalian circadian rhythms. CRY is composed of a structured N-terminal domain known as the photolyase homology region (PHR), which is tethered to an intrinsically disordered C-terminal ...
Gian Carlo G. Parico, Carrie L. Partch
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Vesicle Clustering in a Living Synapse Depends on a Synapsin Region that Mediates Phase Separation
Cell Reports, 2020 Summary: Liquid-liquid phase separation is an increasingly recognized mechanism for compartmentalization in cells. Recent in vitro studies suggest that this organizational principle may apply to synaptic vesicle clusters. Here we test this possibility by
Arndt Pechstein +8 more
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Forkhead followed by disordered tail: The intrinsically disordered regions of FOXO3a [PDF]
Intrinsically Disordered Proteins, 2015 Forkhead box Class O is one of 19 subfamilies of the Forkhead box family, comprising 4 human transcription factors: FOXO1, FOXO3a, FOXO4, and FOXO6, which are involved in many crucial cellular processes. FOXO3a is a tumor suppressor involved in multiple physiological and pathological processes, and plays essential roles in metabolism, cell cycle arrest,
Feng, Wang +2 more
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The Intrinsically Disordered Region of ExbD Is Required for Signal Transduction [PDF]
Journal of Bacteriology, 2019 The TonB system is a virulence factor for Gram-negative pathogens. The mechanism by which cytoplasmic membrane proteins of the TonB system transduce an electrochemical gradient into mechanical energy is a long-standing mystery. TonB, ExbB, and ExbD primary amino acid sequences are characterized by regions of predicted intrinsic ...
Kopp, Dale R., Postle, Kathleen
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Expanded Interactome of the Intrinsically Disordered Protein Dss1
Cell Reports, 2018 Summary: Dss1 (also known as Sem1) is a conserved, intrinsically disordered protein with a remarkably broad functional diversity. It is a proteasome subunit but also associates with the BRCA2, RPA, Csn12-Thp1, and TREX-2 complexes.
Signe M. Schenstrøm +7 more
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Scientific Reports, 2023 The tetrameric tumor suppressor p53 represents a great challenge for 3D-structural analysis due to its high degree of intrinsic disorder (ca. 40%). We aim to shed light on the structural and functional roles of p53’s C-terminal region in full-length ...
Alessio Di Ianni +8 more
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Communications Biology, 2023 Evolution-guided mutagenesis and biophysical analysis reveal that residual helical structure in the binding region of an intrinsically disordered protein regulates the lifetime of its complex by affecting its dissociation.
Steffie Elkjær +6 more
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Communications Biology, 2023 Dynamic docking simulations reveal the interactions and conformational changes of the intrinsically disordered region of Bim and its cryptic binding site in Bcl-xL, a pro-survival protein involved in cancer progression.
Gert-Jan Bekker +4 more
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Compositional Bias of Intrinsically Disordered Proteins and Regions and Their Predictions
Biomolecules, 2022 Intrinsically disordered regions (IDRs) carry out many cellular functions and vary in length and placement in protein sequences. This diversity leads to variations in the underlying compositional biases, which were demonstrated for the short vs. long IDRs. We analyze compositional biases across four classes of disorder: fully disordered proteins; short
Bi Zhao, Lukasz Kurgan
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Nature Communications, 2022 In this work the authors report atomically detailed computer simulations revealing the binding mechanisms of small molecule drugs to an intrinsically disordered region of the androgen receptor, a castration-resistant prostate cancer drug target.
Jiaqi Zhu +2 more
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