Results 21 to 30 of about 32,541 (302)

Phosphorylation of Intrinsically Disordered Regions in Remorin Proteins [PDF]

Frontiers in Plant Science, 2012
Plant-specific remorin proteins reside in subdomains of plasma membranes, originally termed membrane rafts. They probably facilitate cellular signal transduction by direct interaction with signaling proteins such as receptor-like kinases and may dynamically modulate their lateral segregation within plasma membranes.
Marín, Macarena, Ott, Thomas
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Multifunctional Intrinsically Disordered Regions in Transcription Factors

Chemistry – A European Journal, 2023
AbstractEukaryotic transcription factors (TFs) are the final integrators of a complex molecular feedback mechanism that interfaces with the genome, consolidating information for transcriptional regulation. TFs consist of both structured DNA‐binding domains and long intrinsically disordered regions (IDRs) embedded with motifs linked to transcriptional ...
Matti Már, Kateryna Nitsenko, Pétur O. Heidarsson   +2 more
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Classification of Intrinsically Disordered Regions and Proteins

Chemical Reviews, 2014
1.1. Uncharacterized Protein Segments Are a Source of Functional Novelty Over the past decade, we have observed a massive increase in the amount of information describing protein sequences from a variety of organisms.1,2 While this may reflect the diversity in sequence space, and possibly also in function space,3 a large proportion of the sequences ...
Van Der Lee R., Buljan M., Lang B., Weatheritt R. J., Daughdrill G. W., Dunker A. K., Fuxreiter M., Gough J., Gsponer J., Jones D. T., Kim P. M., Kriwacki R. W., Oldfield C. J., Pappu R. V., Tompa P., Uversky V. N., Wright P. E., Babu M. M.   +17 more
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NeProc predicts binding segments in intrinsically disordered regions without learning binding region sequences

Biophysics and Physicobiology, 2020
Intrinsically disordered proteins are those proteins with intrinsically disordered regions. One of the unique characteristics of intrinsically disordered proteins is the existence of functional segments in intrinsically dis­ordered regions.
Hiroto Anbo, Hiroki Amagai, Satoshi Fukuchi   +2 more
doaj   +1 more source

Vesicle Clustering in a Living Synapse Depends on a Synapsin Region that Mediates Phase Separation

Cell Reports, 2020
Summary: Liquid-liquid phase separation is an increasingly recognized mechanism for compartmentalization in cells. Recent in vitro studies suggest that this organizational principle may apply to synaptic vesicle clusters. Here we test this possibility by
Arndt Pechstein, Nikolay Tomilin, Kristin Fredrich, Olga Vorontsova, Elena Sopova, Emma Evergren, Volker Haucke, Lennart Brodin, Oleg Shupliakov   +8 more
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Forkhead followed by disordered tail: The intrinsically disordered regions of FOXO3a [PDF]

Intrinsically Disordered Proteins, 2015
Forkhead box Class O is one of 19 subfamilies of the Forkhead box family, comprising 4 human transcription factors: FOXO1, FOXO3a, FOXO4, and FOXO6, which are involved in many crucial cellular processes. FOXO3a is a tumor suppressor involved in multiple physiological and pathological processes, and plays essential roles in metabolism, cell cycle arrest,
Feng, Wang, Christopher B, Marshall, Mitsuhiko, Ikura   +2 more
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The Intrinsically Disordered Region of ExbD Is Required for Signal Transduction [PDF]

Journal of Bacteriology, 2019
The TonB system is a virulence factor for Gram-negative pathogens. The mechanism by which cytoplasmic membrane proteins of the TonB system transduce an electrochemical gradient into mechanical energy is a long-standing mystery. TonB, ExbB, and ExbD primary amino acid sequences are characterized by regions of predicted intrinsic ...
Kopp, Dale R., Postle, Kathleen
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Evolutionary fine-tuning of residual helix structure in disordered proteins manifests in complex structure and lifetime

Communications Biology, 2023
Evolution-guided mutagenesis and biophysical analysis reveal that residual helical structure in the binding region of an intrinsically disordered protein regulates the lifetime of its complex by affecting its dissociation.
Steffie Elkjær, Amanda D. Due, Lise F. Christensen, Frederik F. Theisen, Lasse Staby, Birthe B. Kragelund, Karen Skriver   +6 more
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Discovery of a Functional Covalent Ligand Targeting an Intrinsically Disordered Cysteine within MYC [PDF]

, 2021
MYC is a major oncogenic transcriptional driver of most human cancers that has remained intractable to direct targeting because much of MYC is intrinsically disordered.
Co, Jennifer, Liu, Gang, McKenna, Jeffrey M, Cioffi, Alexander G, Tallarico, John A, Schirle, Markus, Nomura, Daniel K, Jones, Michael D, Boike, Lydia, Majewski, Felix C, Henning, Nathaniel J   +10 more
core   +1 more source

Many-to-one binding by intrinsically disordered protein regions [PDF]

Biocomputing 2020, 2019
Disordered binding regions (DBRs), which are embedded within intrinsically disordered proteins or regions (IDPs or IDRs), enable IDPs or IDRs to mediate multiple protein-protein interactions. DBR-protein complexes were collected from the Protein Data Bank for which two or more DBRs having different amino acid sequences bind to the same (100% sequence ...
Alterovitz, Wei-Lun, Faraggi, Eshel, Oldfield, Christopher J., Meng, Jingwei, Xue, Bin, Huang, Fei, Romero, Pedro, Kloczkowski, Andrzej, Uversky, Vladimir N., Dunker, A. Keith   +9 more
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