Results 21 to 30 of about 4,409,964 (303)

Polycation-π Interactions Are a Driving Force for Molecular Recognition by an Intrinsically Disordered Oncoprotein Family [PDF]

, 2013
Molecular recognition by intrinsically disordered proteins (IDPs) commonly involves specific localized contacts and target-induced disorder to order transitions.
Sheung Chun Ng, Ng Sheung Chun, Hue Sun Chan (135066), Chan, Hue Sun, Song Jianhui, Song, Jianhui, Jianhui Song, Tompa, Péter, Lee Kevin A. W., Peter Tompa, Lee, Kevin Andrew William, Sheung Chun Ng (463510), Jianhui Song (463509), Tompa Peter, Hue Sun Chan, Peter Tompa (38445), Chan Hue Sun, Ng, Sheung Chun, Kevin A. W. Lee (7686), Kevin A W Lee   +19 more
core   +1 more source

The Intrinsically Disordered Region of ExbD Is Required for Signal Transduction [PDF]

Journal of Bacteriology, 2019
The TonB system is a virulence factor for Gram-negative pathogens. The mechanism by which cytoplasmic membrane proteins of the TonB system transduce an electrochemical gradient into mechanical energy is a long-standing mystery. TonB, ExbB, and ExbD primary amino acid sequences are characterized by regions of predicted intrinsic ...
Kopp, Dale R., Postle, Kathleen
openaire   +3 more sources

Folding factors and partners for the intrinsically disordered protein Micro-Exon Gene 14 (MEG-14) [PDF]

, 2013
The micro-exon genes (MEG) of Schistosoma mansoni, a parasite responsible for the second most widely spread tropical disease, code for small secreted proteins with sequences unique to the Schistosoma genera.
Orcia, Debora, Araujo, A.P.U., Wallace, Bonnie A., Araújo, Ana Paula Ulian de, De Marco, Ricardo, Debora Orcia, Wallace, B. A., Lopes, Jose Luiz S., Lopes, J.L.S., Ricardo DeMarco, Ana Paula U. Araujo, Orcia, D., B.A. Wallace, Jose Luiz S. Lopes, DeMarco, R.   +14 more
core   +1 more source

Expanded Interactome of the Intrinsically Disordered Protein Dss1

Cell Reports, 2018
Summary: Dss1 (also known as Sem1) is a conserved, intrinsically disordered protein with a remarkably broad functional diversity. It is a proteasome subunit but also associates with the BRCA2, RPA, Csn12-Thp1, and TREX-2 complexes.
Signe M. Schenstrøm, Caio A. Rebula, Michael H. Tatham, Ruth Hendus-Altenburger, Isabelle Jourdain, Ronald T. Hay, Birthe B. Kragelund, Rasmus Hartmann-Petersen   +7 more
doaj   +1 more source

Structural assessment of the full-length wild-type tumor suppressor protein p53 by mass spectrometry-guided computational modeling

Scientific Reports, 2023
The tetrameric tumor suppressor p53 represents a great challenge for 3D-structural analysis due to its high degree of intrinsic disorder (ca. 40%). We aim to shed light on the structural and functional roles of p53’s C-terminal region in full-length ...
Alessio Di Ianni, Christian Tüting, Marc Kipping, Christian H. Ihling, Janett Köppen, Claudio Iacobucci, Christian Arlt, Panagiotis L. Kastritis, Andrea Sinz   +8 more
doaj   +1 more source

The N-terminal intrinsically disordered domain of mgm101p is localized to the mitochondrial nucleoid. [PDF]

, 2013
The mitochondrial genome maintenance gene, MGM101, is essential for yeasts that depend on mitochondrial DNA replication. Previously, in Saccharomyces cerevisiae, it has been found that the carboxy-terminal two-thirds of Mgm101p has a functional core ...
George Desmond Clark-Walker (281878), George Desmond Clark-Walker, Dosztányi Zsuzsanna, Zsuzsanna Dosztányi (57464), Clark-Walker, George Desmond, Zsuzsanna Dosztányi, Clark-Walker George Desmond, David C. Hayward (198611), David C. Hayward, Hayward David C., Hayward, David C., Dosztányi, Zsuzsanna, David C Hayward   +12 more
core   +2 more sources

Evolutionary fine-tuning of residual helix structure in disordered proteins manifests in complex structure and lifetime

Communications Biology, 2023
Evolution-guided mutagenesis and biophysical analysis reveal that residual helical structure in the binding region of an intrinsically disordered protein regulates the lifetime of its complex by affecting its dissociation.
Steffie Elkjær, Amanda D. Due, Lise F. Christensen, Frederik F. Theisen, Lasse Staby, Birthe B. Kragelund, Karen Skriver   +6 more
doaj   +1 more source

Mutual induced-fit mechanism drives binding between intrinsically disordered Bim and cryptic binding site of Bcl-xL

Communications Biology, 2023
Dynamic docking simulations reveal the interactions and conformational changes of the intrinsically disordered region of Bim and its cryptic binding site in Bcl-xL, a pro-survival protein involved in cancer progression.
Gert-Jan Bekker, Mitsugu Araki, Kanji Oshima, Yasushi Okuno, Narutoshi Kamiya   +4 more
doaj   +1 more source

Sequence-Dependent Correlated Segments in the Intrinsically Disordered Region of ChiZ

Biomolecules, 2020
How sequences of intrinsically disordered proteins (IDPs) code for their conformational dynamics is poorly understood. Here, we combined NMR spectroscopy, small-angle X-ray scattering (SAXS), and molecular dynamics (MD) simulations to characterize the ...
Alan Hicks, Cristian A. Escobar, Timothy A. Cross, Huan-Xiang Zhou   +3 more
doaj   +1 more source

Small molecules targeting the disordered transactivation domain of the androgen receptor induce the formation of collapsed helical states

Nature Communications, 2022
In this work the authors report atomically detailed computer simulations revealing the binding mechanisms of small molecule drugs to an intrinsically disordered region of the androgen receptor, a castration-resistant prostate cancer drug target.
Jiaqi Zhu, Xavier Salvatella, Paul Robustelli   +2 more
doaj   +1 more source