Results 11 to 20 of about 32,541 (302)

The repeat region of cortactin is intrinsically disordered in solution [PDF]

Scientific Reports, 2017
The multi-domain protein, cortactin, contains a 37-residue repeating motif that binds to actin filaments. This cortactin repeat region comprises 6½ similar copies of the motif and binds actin filaments.
Yeqing Tao, Alexander N. Scherer, Titus J. Boggon, Alan G. Marshall, Anthony J. Koleske, Xiaofeng Li, TuKiet T. Lam, James W. Murphy   +7 more
core   +3 more sources

The tail of cryptochromes: an intrinsically disordered cog within the mammalian circadian clock [PDF]

Cell Communication and Signaling, 2020
Cryptochrome (CRY) proteins play an essential role in regulating mammalian circadian rhythms. CRY is composed of a structured N-terminal domain known as the photolyase homology region (PHR), which is tethered to an intrinsically disordered C-terminal ...
Gian Carlo G. Parico, Carrie L. Partch
doaj   +2 more sources

Expanded Interactome of the Intrinsically Disordered Protein Dss1 [PDF]

Cell Reports, 2018
Summary: Dss1 (also known as Sem1) is a conserved, intrinsically disordered protein with a remarkably broad functional diversity. It is a proteasome subunit but also associates with the BRCA2, RPA, Csn12-Thp1, and TREX-2 complexes.
Signe M. Schenstrøm, Caio A. Rebula, Michael H. Tatham, Ruth Hendus-Altenburger, Isabelle Jourdain, Ronald T. Hay, Birthe B. Kragelund, Rasmus Hartmann-Petersen   +7 more
doaj   +2 more sources

JMJD3 intrinsically disordered region links the 3D-genome structure to TGFβ-dependent transcription activation [PDF]

Nature Communications, 2022
Here the authors demonstrate that TGFβ drives multi-enhancer contacts and ultimately gene activation during neuronal commitment, and that this requires the intrinsically disordered region (IDR) of the histone demethylase JMJD3 likely through its role in ...
Marta Vicioso-Mantis, Raquel Fueyo, Claudia Navarro, Sara Cruz-Molina, Wilfred F. J. van Ijcken, Elena Rebollo, Álvaro Rada-Iglesias, Marian A. Martínez-Balbás   +7 more
doaj   +2 more sources

Allosteric modulation of nucleoporin assemblies by intrinsically disordered regions. [PDF]

Science Advances, 2020
Intrinsically disordered regions (IDRs) of proteins are implicated in key macromolecular interactions. However, the molecular forces underlying IDR function within multicomponent assemblies remain elusive.
Seo, Hyuk-Soo, Blus, Bartlomiej Jan, Koh, Junseock, Coutavas, Elias, Blobel, Günter, Krolak, Aleksandra   +5 more
core   +3 more sources

Sequence-Dependent Correlated Segments in the Intrinsically Disordered Region of ChiZ [PDF]

Biomolecules, 2020
How sequences of intrinsically disordered proteins (IDPs) code for their conformational dynamics is poorly understood. Here, we combined NMR spectroscopy, small-angle X-ray scattering (SAXS), and molecular dynamics (MD) simulations to characterize the ...
Alan Hicks, Cristian A. Escobar, Timothy A. Cross, Huan-Xiang Zhou   +3 more
doaj   +3 more sources

Design of intrinsically disordered region binding proteins. [PDF]

Science
Abstract Intrinsically disordered proteins and peptides play key roles in biology, but the lack of defined structures and the high variability in sequence and conformational preferences has made targeting such systems challenging. We describe a general approach for designing proteins that bind intrinsically disordered protein regions in
Wu K, Jiang H, Hicks DR, Liu C, Muratspahić E, Ramelot TA, Liu Y, McNally K, Kenny S, Mihut A, Gaur A, Coventry B, Chen W, Bera AK, Kang A, Gerben S, Lamb MY, Murray A, Li X, Kennedy MA, Yang W, Song Z, Schober G, Brierley SM, O'Neill J, Gelb MH, Montelione GT, Derivery E, Baker D.   +28 more
europepmc   +5 more sources

Intrinsically disordered regions in the rodent hepevirus proteome [PDF]

Bioinformation, 2022
Hepatitis E virus (HEV) is the causative agent of Hepatitis E infections across the world. Intrinsically disordered protein regions (IDPRs) or intrinsically disordered proteins (IDPs) are regions or proteins that are characterized by lack of definite structure.
Shafat, Zoya, Ahmed, Anwar, Parvez, Mohammad K, Islam, Asimul, Parveen, Shama   +4 more
openaire   +2 more sources

Intrinsically disordered proteins and proteins with intrinsically disordered regions in neurodegenerative diseases

Biophysical Reviews, 2022
Many different intrinsically disordered proteins and proteins with intrinsically disordered regions are associated with neurodegenerative diseases. These types of proteins including amyloid-β, tau, α-synuclein, CHCHD2, CHCHD10, and G-protein coupled receptors are increasingly becoming evaluated as potential drug targets in the pharmaceutical-based ...
Orkid Coskuner-Weber, Ozan Mirzanli, Vladimir N. Uversky   +2 more
openaire   +4 more sources

Intrinsically disordered regions in autophagy proteins [PDF]

Proteins: Structure, Function, and Bioinformatics, 2013
ABSTRACTAutophagy is an essential eukaryotic pathway required for cellular homeostasis. Numerous key autophagy effectors and regulators have been identified, but the mechanism by which they carry out their function in autophagy is not fully understood.
Yang, Mei, Minfei, Su, Gaurav, Soni, Saeed, Salem, Christopher L, Colbert, Sangita C, Sinha   +5 more
openaire   +2 more sources