Results 11 to 20 of about 4,409,964 (303)

The repeat region of cortactin is intrinsically disordered in solution [PDF]

Scientific Reports, 2017
The multi-domain protein, cortactin, contains a 37-residue repeating motif that binds to actin filaments. This cortactin repeat region comprises 6½ similar copies of the motif and binds actin filaments.
Yeqing Tao, Alexander N. Scherer, Titus J. Boggon, Alan G. Marshall, Anthony J. Koleske, Xiaofeng Li, TuKiet T. Lam, James W. Murphy   +7 more
core   +3 more sources

Structural and functional studies of intrinsically disordered fibronectin-binding proteins [PDF]

, 2009
Bacterial fibronectin-binding proteins (FnBPs) mediate adhesion of bacteria to host tissues through binding to the human protein fibronectin (Fn). FnBPs are predicted to contain a series of intrinsically disordered Fn-binding repeats (FnBRs), which ...
Norris, Nicole Catherine
core   +6 more sources

Design of intrinsically disordered region binding proteins. [PDF]

Science
Abstract Intrinsically disordered proteins and peptides play key roles in biology, but the lack of defined structures and the high variability in sequence and conformational preferences has made targeting such systems challenging. We describe a general approach for designing proteins that bind intrinsically disordered protein regions in
Wu K, Jiang H, Hicks DR, Liu C, Muratspahić E, Ramelot TA, Liu Y, McNally K, Kenny S, Mihut A, Gaur A, Coventry B, Chen W, Bera AK, Kang A, Gerben S, Lamb MY, Murray A, Li X, Kennedy MA, Yang W, Song Z, Schober G, Brierley SM, O'Neill J, Gelb MH, Montelione GT, Derivery E, Baker D.   +28 more
europepmc   +5 more sources

Intrinsically disordered regions in the rodent hepevirus proteome [PDF]

Bioinformation, 2022
Hepatitis E virus (HEV) is the causative agent of Hepatitis E infections across the world. Intrinsically disordered protein regions (IDPRs) or intrinsically disordered proteins (IDPs) are regions or proteins that are characterized by lack of definite structure.
Shafat, Zoya, Ahmed, Anwar, Parvez, Mohammad K, Islam, Asimul, Parveen, Shama   +4 more
openaire   +2 more sources

Intrinsically disordered regions in autophagy proteins [PDF]

Proteins: Structure, Function, and Bioinformatics, 2013
ABSTRACTAutophagy is an essential eukaryotic pathway required for cellular homeostasis. Numerous key autophagy effectors and regulators have been identified, but the mechanism by which they carry out their function in autophagy is not fully understood.
Yang, Mei, Minfei, Su, Gaurav, Soni, Saeed, Salem, Christopher L, Colbert, Sangita C, Sinha   +5 more
openaire   +2 more sources

Phosphorylation of Intrinsically Disordered Regions in Remorin Proteins [PDF]

Frontiers in Plant Science, 2012
Plant-specific remorin proteins reside in subdomains of plasma membranes, originally termed membrane rafts. They probably facilitate cellular signal transduction by direct interaction with signaling proteins such as receptor-like kinases and may dynamically modulate their lateral segregation within plasma membranes.
Marín, Macarena, Ott, Thomas
openaire   +5 more sources

Multifunctional Intrinsically Disordered Regions in Transcription Factors

Chemistry – A European Journal, 2023
Abstract Eukaryotic transcription factors (TFs) are the final integrators of a complex molecular feedback mechanism that interfaces with the genome, consolidating information for transcriptional regulation. TFs consist of both structured DNA‐binding domains and long intrinsically disordered regions (IDRs) embedded with motifs linked ...
Matti Már, Kateryna Nitsenko, Pétur O. Heidarsson   +2 more
openaire   +2 more sources

Vesicle Clustering in a Living Synapse Depends on a Synapsin Region that Mediates Phase Separation

Cell Reports, 2020
Summary: Liquid-liquid phase separation is an increasingly recognized mechanism for compartmentalization in cells. Recent in vitro studies suggest that this organizational principle may apply to synaptic vesicle clusters. Here we test this possibility by
Arndt Pechstein, Nikolay Tomilin, Kristin Fredrich, Olga Vorontsova, Elena Sopova, Emma Evergren, Volker Haucke, Lennart Brodin, Oleg Shupliakov   +8 more
doaj   +1 more source

Structural characterization of intrinsically disordered proteins by NMR spectroscopy. [PDF]

, 2013
Recent advances in NMR methodology and techniques allow the structural investigation of biomolecules of increasing size with atomic resolution. NMR spectroscopy is especially well-suited for the study of intrinsically disordered proteins (IDPs) and ...
Contreras-Martos, Sara, Peter Tompa, Cedeno, Cesyen, Simone Kosol, Kosol, Simone, Tompa, Péter, Sara Contreras-Martos, Cesyen Cedeño   +7 more
core   +1 more source

Forkhead followed by disordered tail: The intrinsically disordered regions of FOXO3a [PDF]

Intrinsically Disordered Proteins, 2015
Forkhead box Class O is one of 19 subfamilies of the Forkhead box family, comprising 4 human transcription factors: FOXO1, FOXO3a, FOXO4, and FOXO6, which are involved in many crucial cellular processes. FOXO3a is a tumor suppressor involved in multiple physiological and pathological processes, and plays essential roles in metabolism, cell cycle arrest,
Feng, Wang, Christopher B, Marshall, Mitsuhiko, Ikura   +2 more
openaire   +2 more sources