Results 11 to 20 of about 32,259 (261)

Sequence-Dependent Correlated Segments in the Intrinsically Disordered Region of ChiZ [PDF]

Biomolecules, 2020
How sequences of intrinsically disordered proteins (IDPs) code for their conformational dynamics is poorly understood. Here, we combined NMR spectroscopy, small-angle X-ray scattering (SAXS), and molecular dynamics (MD) simulations to characterize the ...
Alan Hicks, Cristian A. Escobar, Timothy A. Cross, Huan-Xiang Zhou   +3 more
doaj   +3 more sources

Intrinsically disordered regions in the rodent hepevirus proteome [PDF]

Bioinformation, 2022
Hepatitis E virus (HEV) is the causative agent of Hepatitis E infections across the world. Intrinsically disordered protein regions (IDPRs) or intrinsically disordered proteins (IDPs) are regions or proteins that are characterized by lack of definite structure.
Shafat, Zoya, Ahmed, Anwar, Parvez, Mohammad K, Islam, Asimul, Parveen, Shama   +4 more
openaire   +2 more sources

Design of intrinsically disordered region binding proteins. [PDF]

Science
Abstract Intrinsically disordered proteins and peptides play key roles in biology, but the lack of defined structures and the high variability in sequence and conformational preferences has made targeting such systems challenging. We describe a general approach for designing proteins that bind intrinsically disordered protein regions in
Wu K, Jiang H, Hicks DR, Liu C, Muratspahić E, Ramelot TA, Liu Y, McNally K, Kenny S, Mihut A, Gaur A, Coventry B, Chen W, Bera AK, Kang A, Gerben S, Lamb MY, Murray A, Li X, Kennedy MA, Yang W, Song Z, Schober G, Brierley SM, O'Neill J, Gelb MH, Montelione GT, Derivery E, Baker D.   +28 more
europepmc   +5 more sources

Intrinsically disordered proteins and proteins with intrinsically disordered regions in neurodegenerative diseases

Biophysical Reviews, 2022
Many different intrinsically disordered proteins and proteins with intrinsically disordered regions are associated with neurodegenerative diseases. These types of proteins including amyloid-β, tau, α-synuclein, CHCHD2, CHCHD10, and G-protein coupled receptors are increasingly becoming evaluated as potential drug targets in the pharmaceutical-based ...
Orkid Coskuner-Weber, Ozan Mirzanli, Vladimir N. Uversky   +2 more
openaire   +4 more sources

Intrinsically disordered regions in autophagy proteins [PDF]

Proteins: Structure, Function, and Bioinformatics, 2013
ABSTRACTAutophagy is an essential eukaryotic pathway required for cellular homeostasis. Numerous key autophagy effectors and regulators have been identified, but the mechanism by which they carry out their function in autophagy is not fully understood.
Yang, Mei, Minfei, Su, Gaurav, Soni, Saeed, Salem, Christopher L, Colbert, Sangita C, Sinha   +5 more
openaire   +2 more sources

Phosphorylation of Intrinsically Disordered Regions in Remorin Proteins [PDF]

Frontiers in Plant Science, 2012
Plant-specific remorin proteins reside in subdomains of plasma membranes, originally termed membrane rafts. They probably facilitate cellular signal transduction by direct interaction with signaling proteins such as receptor-like kinases and may dynamically modulate their lateral segregation within plasma membranes.
Marín, Macarena, Ott, Thomas
openaire   +5 more sources

Multifunctional Intrinsically Disordered Regions in Transcription Factors

Chemistry – A European Journal, 2023
AbstractEukaryotic transcription factors (TFs) are the final integrators of a complex molecular feedback mechanism that interfaces with the genome, consolidating information for transcriptional regulation. TFs consist of both structured DNA‐binding domains and long intrinsically disordered regions (IDRs) embedded with motifs linked to transcriptional ...
Matti Már, Kateryna Nitsenko, Pétur O. Heidarsson   +2 more
openaire   +2 more sources

Classification of Intrinsically Disordered Regions and Proteins

Chemical Reviews, 2014
1.1. Uncharacterized Protein Segments Are a Source of Functional Novelty Over the past decade, we have observed a massive increase in the amount of information describing protein sequences from a variety of organisms.1,2 While this may reflect the diversity in sequence space, and possibly also in function space,3 a large proportion of the sequences ...
Van Der Lee R., Buljan M., Lang B., Weatheritt R. J., Daughdrill G. W., Dunker A. K., Fuxreiter M., Gough J., Gsponer J., Jones D. T., Kim P. M., Kriwacki R. W., Oldfield C. J., Pappu R. V., Tompa P., Uversky V. N., Wright P. E., Babu M. M.   +17 more
openaire   +5 more sources

The repeat region of cortactin is intrinsically disordered in solution [PDF]

Scientific Reports, 2017
AbstractThe multi-domain protein, cortactin, contains a 37-residue repeating motif that binds to actin filaments. This cortactin repeat region comprises 6½ similar copies of the motif and binds actin filaments. To better understand this region of cortactin, and its fold, we conducted extensive biophysical analysis.
Xiaofeng Li, Yeqing Tao, James W. Murphy, Alexander N. Scherer, TuKiet T. Lam, Alan G. Marshall, Anthony J. Koleske, Titus J. Boggon   +7 more
openaire   +2 more sources

NeProc predicts binding segments in intrinsically disordered regions without learning binding region sequences

Biophysics and Physicobiology, 2020
Intrinsically disordered proteins are those proteins with intrinsically disordered regions. One of the unique characteristics of intrinsically disordered proteins is the existence of functional segments in intrinsically dis­ordered regions.
Hiroto Anbo, Hiroki Amagai, Satoshi Fukuchi   +2 more
doaj   +1 more source