Results 31 to 40 of about 32,259 (261)
DARUMA: a gateway to fast and easy prediction of intrinsically disordered regions [PDF]
PeerJ Computer ScienceBackground Intrinsically disordered proteins (IDPs) are proteins that contain intrinsically disordered regions (IDRs), which lack stable three-dimensional structures under physiological conditions.
Itsuki Shimizu +4 more
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Cell Communication and Signaling, 2021 Background The non-receptor tyrosine kinase Abelson (Abl) is a key player in oncogenesis, with kinase inhibitors serving as paradigms of targeted therapy.
Edward M. Rogers +2 more
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Entropy and Information within Intrinsically Disordered Protein Regions [PDF]
Entropy, 2019 Bioinformatics and biophysical studies of intrinsically disordered proteins and regions (IDRs) note the high entropy at individual sequence positions and in conformations sampled in solution. This prevents application of the canonical sequence-structure-function paradigm to IDRs and motivates the development of new methods to extract information from ...
Iva Pritisanac +3 more
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Order, Disorder, and Everything in Between
Molecules, 2016 In addition to the “traditional” proteins characterized by the unique crystal-like structures needed for unique functions, it is increasingly recognized that many proteins or protein regions (collectively known as intrinsically disordered proteins (IDPs)
Shelly DeForte, Vladimir N. Uversky
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The intrinsically disordered region of coronins fine-tunes oligomerization and actin polymerization
Cell Reports, 2023 Summary: Coronins play critical roles in actin network formation. The diverse functions of coronins are regulated by the structured N-terminal β propeller and the C-terminal coiled coil (CC).
Xiao Han +8 more
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Large extent of disorder in Adenomatous Polyposis Coli offers a strategy to guard Wnt signalling against point mutations. [PDF]
PLoS ONE, 2013 Mutations in the central region of the signalling hub Adenomatous Polyposis Coli (APC) cause colorectal tumourigenesis. The structure of this region remained unknown.
David P Minde +4 more
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Intrinsic Disorder in Proteins with Pathogenic Repeat Expansions
Molecules, 2017 Intrinsically disordered proteins and proteins with intrinsically disordered regions have been shown to be highly prevalent in disease. Furthermore, disease-causing expansions of the regions containing tandem amino acid repeats often push repetitive ...
April L. Darling, Vladimir N. Uversky
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DisoMCS: Accurately Predicting Protein Intrinsically Disordered Regions Using a Multi-Class Conservative Score Approach. [PDF]
PLoS ONE, 2015 The precise prediction of protein intrinsically disordered regions, which play a crucial role in biological procedures, is a necessary prerequisite to further the understanding of the principles and mechanisms of protein function.
Zhiheng Wang +3 more
doaj +1 more source
Cell Communication and Signaling, 2020 The serine/threonine phosphatase calcineurin acts as a crucial connection between calcium signaling the phosphorylation states of numerous important substrates.
Trevor P. Creamer
doaj +1 more source
Allosteric modulation of nucleoporin assemblies by intrinsically disordered regions [PDF]
Science Advances, 2019 Kap121 interacts with an intrinsically disordered region of Nup53 to allosterically modulate Nup53 binding to partner nucleoporins.
Bartlomiej Jan Blus +5 more
openaire +2 more sources