Results 31 to 40 of about 32,541 (302)

The TRIP12's intrinsically disordered region induces chromatin condensates and interferes with nuclear processes. [PDF]

iScience
Summary: Chromatin compaction is crucial for faithful expression and genome integrity. It implies numerous proteins and complex molecular mechanisms. The TRIP12 E3 ubiquitin ligase is tightly associated to chromatin and overexpressed in several types of ...
Vargas C, Ricard A, Varry D, Muzzopappa F, Brunet M, Larrieu D, Erdel F, Labrousse G, Hanoun N, Ligat L, Farcé M, Bery N, Cordelier P, Dufresne M, Torrisani J.   +14 more
europepmc   +2 more sources

Structural assessment of the full-length wild-type tumor suppressor protein p53 by mass spectrometry-guided computational modeling

Scientific Reports, 2023
The tetrameric tumor suppressor p53 represents a great challenge for 3D-structural analysis due to its high degree of intrinsic disorder (ca. 40%). We aim to shed light on the structural and functional roles of p53’s C-terminal region in full-length ...
Alessio Di Ianni, Christian Tüting, Marc Kipping, Christian H. Ihling, Janett Köppen, Claudio Iacobucci, Christian Arlt, Panagiotis L. Kastritis, Andrea Sinz   +8 more
doaj   +1 more source

DARUMA: a gateway to fast and easy prediction of intrinsically disordered regions [PDF]

PeerJ Computer Science
Background Intrinsically disordered proteins (IDPs) are proteins that contain intrinsically disordered regions (IDRs), which lack stable three-dimensional structures under physiological conditions.
Itsuki Shimizu, Takuya Ida, Yuhei Ozawa, Satoshi Fukuchi, Hiroto Anbo   +4 more
doaj   +2 more sources

Mutual induced-fit mechanism drives binding between intrinsically disordered Bim and cryptic binding site of Bcl-xL

Communications Biology, 2023
Dynamic docking simulations reveal the interactions and conformational changes of the intrinsically disordered region of Bim and its cryptic binding site in Bcl-xL, a pro-survival protein involved in cancer progression.
Gert-Jan Bekker, Mitsugu Araki, Kanji Oshima, Yasushi Okuno, Narutoshi Kamiya   +4 more
doaj   +1 more source

Small molecules targeting the disordered transactivation domain of the androgen receptor induce the formation of collapsed helical states

Nature Communications, 2022
In this work the authors report atomically detailed computer simulations revealing the binding mechanisms of small molecule drugs to an intrinsically disordered region of the androgen receptor, a castration-resistant prostate cancer drug target.
Jiaqi Zhu, Xavier Salvatella, Paul Robustelli   +2 more
doaj   +1 more source

Dss1 Is a 26S Proteasome Ubiquitin Receptor [PDF]

, 2014
The ubiquitin-proteasome system is the major pathway for protein degradation in eukaryotic cells. Proteins to be degraded are conjugated to ubiquitin chains that act as recognition signals for the 26S proteasome.
Hardwick, Kevin G., Hay, Ronald T., Larsen, Ida B., Kragelund, Birthe B., Tatham, Michael H, Rösner, Heike I, Kragelund, Birthe Brandt, Hay, Ronald T, Kragelund, Birthe B, Kriegenburg, Franziska, Tatham, Michael H., Rösner, Heike Ilona, Paraskevopoulos, Konstantinos, Brandstrup, Rikke, Larsen, Ida B, Medina, Bethan; id_orcid, Hartmann-Petersen, Rasmus, Gordon, Colin, Rösner, Heike I., Hardwick, Kevin G, Medina, Bethan   +20 more
core   +1 more source

Compositional Bias of Intrinsically Disordered Proteins and Regions and Their Predictions

Biomolecules, 2022
Intrinsically disordered regions (IDRs) carry out many cellular functions and vary in length and placement in protein sequences. This diversity leads to variations in the underlying compositional biases, which were demonstrated for the short vs. long IDRs. We analyze compositional biases across four classes of disorder: fully disordered proteins; short
Bi Zhao, Lukasz Kurgan
openaire   +3 more sources

Abelson kinase’s intrinsically disordered region plays essential roles in protein function and protein stability

Cell Communication and Signaling, 2021
Background The non-receptor tyrosine kinase Abelson (Abl) is a key player in oncogenesis, with kinase inhibitors serving as paradigms of targeted therapy.
Edward M. Rogers, S. Colby Allred, Mark Peifer   +2 more
doaj   +1 more source

Order, Disorder, and Everything in Between

Molecules, 2016
In addition to the “traditional” proteins characterized by the unique crystal-like structures needed for unique functions, it is increasingly recognized that many proteins or protein regions (collectively known as intrinsically disordered proteins (IDPs)
Shelly DeForte, Vladimir N. Uversky
doaj   +1 more source

Large extent of disorder in Adenomatous Polyposis Coli offers a strategy to guard Wnt signalling against point mutations. [PDF]

PLoS ONE, 2013
Mutations in the central region of the signalling hub Adenomatous Polyposis Coli (APC) cause colorectal tumourigenesis. The structure of this region remained unknown.
David P Minde, Martina Radli, Federico Forneris, Madelon M Maurice, Stefan G D Rüdiger   +4 more
doaj   +1 more source