DARUMA: a gateway to fast and easy prediction of intrinsically disordered regions [PDF]
PeerJ Computer ScienceBackground Intrinsically disordered proteins (IDPs) are proteins that contain intrinsically disordered regions (IDRs), which lack stable three-dimensional structures under physiological conditions.
Itsuki Shimizu +4 more
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Cell Communication and Signaling, 2021 Background The non-receptor tyrosine kinase Abelson (Abl) is a key player in oncogenesis, with kinase inhibitors serving as paradigms of targeted therapy.
Edward M. Rogers +2 more
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The intrinsically disordered region of coronins fine-tunes oligomerization and actin polymerization
Cell Reports, 2023 Summary: Coronins play critical roles in actin network formation. The diverse functions of coronins are regulated by the structured N-terminal β propeller and the C-terminal coiled coil (CC).
Xiao Han +8 more
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Order from Disorder with Intrinsically Disordered Peptide Amphiphiles [PDF]
, 2021 Amphiphilic molecules and their self-assembled structures have long been the target of extensive research due to their potential applications in fields ranging from materials design to biomedical and cosmetic applications.
Hila, Shinar +9 more
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Compositional Bias of Intrinsically Disordered Proteins and Regions and Their Predictions
Biomolecules, 2022 Intrinsically disordered regions (IDRs) carry out many cellular functions and vary in length and placement in protein sequences. This diversity leads to variations in the underlying compositional biases, which were demonstrated for the short vs. long IDRs. We analyze compositional biases across four classes of disorder: fully disordered proteins; short
Bi Zhao, Lukasz Kurgan
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Order, Disorder, and Everything in Between
Molecules, 2016 In addition to the “traditional” proteins characterized by the unique crystal-like structures needed for unique functions, it is increasingly recognized that many proteins or protein regions (collectively known as intrinsically disordered proteins (IDPs)
Shelly DeForte, Vladimir N. Uversky
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Large extent of disorder in Adenomatous Polyposis Coli offers a strategy to guard Wnt signalling against point mutations. [PDF]
PLoS ONE, 2013 Mutations in the central region of the signalling hub Adenomatous Polyposis Coli (APC) cause colorectal tumourigenesis. The structure of this region remained unknown.
David P Minde +4 more
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DisoMCS: Accurately Predicting Protein Intrinsically Disordered Regions Using a Multi-Class Conservative Score Approach. [PDF]
PLoS ONE, 2015 The precise prediction of protein intrinsically disordered regions, which play a crucial role in biological procedures, is a necessary prerequisite to further the understanding of the principles and mechanisms of protein function.
Zhiheng Wang +3 more
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Analysis of structured and intrinsically disordered regions of transmembrane proteins [PDF]
Molecular BioSystems, 2009 Abstract Integral membraneproteins display two major types of transmembrane structure, helical bundles and beta barrels. The main functional roles of transmembrane proteins are the transport of small molecules and cellsignaling, and sometimes these two roles are coupled.
Xue, Bin +4 more
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Intrinsic Disorder in Proteins with Pathogenic Repeat Expansions
Molecules, 2017 Intrinsically disordered proteins and proteins with intrinsically disordered regions have been shown to be highly prevalent in disease. Furthermore, disease-causing expansions of the regions containing tandem amino acid repeats often push repetitive ...
April L. Darling, Vladimir N. Uversky
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