Results 41 to 50 of about 317,196 (344)
Intron-mediated enhancement is not limited to introns [PDF]
, 2018 AbstractCertain introns strongly increase mRNA accumulation by a poorly understood mechanism known as Intron-Mediated Enhancement (IME). Introns that boost expression by IME have no effect when located upstream of or more than ~1 Kb downstream from the start of transcription.
Gallegos, Jenna E, Rose, Alan B
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Genetics Selection Evolution, 2003 We recently reported that a goat bacterial artificial chromosome (BAC) clone conferred site-independent expression in transgenic mice of the two loci present within its insert, the ubiquitously expressed Cyclin T1 and the mammary specific β-lactalbumin ...
Jean-Luc Vilotte +6 more
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Intron retention is a source of neoepitopes in cancer
Nature Biotechnology, 2018 We present an in silico approach to identifying neoepitopes derived from intron retention events in tumor transcriptomes. Using mass spectrometry immunopeptidome analysis, we show that retained intron neoepitopes are processed and presented on MHC I on ...
A. Smart +8 more
semanticscholar +1 more source
Intron or no intron: a matter for nuclear pore complexes [PDF]
Nucleus, 2015 Nuclear pore complexes (NPCs) have been shown to regulate distinct steps of the gene expression process, from transcription to mRNA export. In particular, mRNAs expressed from intron-containing genes are surveyed by a specific NPC-dependent quality control pathway ensuring that unspliced mRNAs are retained within the nucleus.
Benoit Palancade, Amandine Bonnet
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A New Reference Genome Assembly for the Microcrustacean Daphnia pulex
G3: Genes, Genomes, Genetics, 2017 Comparing genomes of closely related genotypes from populations with distinct demographic histories can help reveal the impact of effective population size on genome evolution. For this purpose, we present a high quality genome assembly of Daphnia pulex (
Zhiqiang Ye +12 more
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Frontiers in Microbiology, 2020 Phallus indusiatus and Phallus echinovolvatus are edible bamboo mushrooms with pharmacological properties. We sequenced, assembled, annotated, and compared the mitogenomes of these species.
Cheng Chen +10 more
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BMC Bioinformatics, 2002 BackgroundComparative analysis of RNA sequences is the basis for the detailed and accurate predictions of RNA structure and the determination of phylogenetic relationships for organisms that span the entire phylogenetic tree.
J. Cannone +13 more
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In search of lost introns [PDF]
Bioinformatics, 2007 Abstract Many fundamental questions concerning the emergence and subsequent evolution of eukaryotic exon–intron organization are still unsettled. Genome-scale comparative studies, which can shed light on crucial aspects of eukaryotic evolution, require adequate computational tools.
Holey, J Andrew +2 more
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Methods and Protocols, 2022 Intron evolution may be readily imaged through the combined use of the “dot plot” function of the NCBI BLAST, aligning two sequences at a time, and the Vertebrate “Multiz” alignment and conservation tool of the UCSC Genome Browser. With the NCBI BLAST, an ideal alignment of two highly conserved sequences generates a diagonal straight line in the plot ...
Maria Antonietta Panaro +4 more
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Intron retention as a component of regulated gene expression programs
Human Genetics, 2017 Intron retention has long been an exemplar of regulated splicing with case studies of individual events serving as models that provided key mechanistic insights into the process of splicing control.
Aishwarya G Jacob +1 more
semanticscholar +1 more source