Results 1 to 10 of about 292,600 (397)
In search of lost introns [PDF]
Bioinformatics, 2007 Many fundamental questions concerning the emergence and subsequent evolution of eukaryotic exon-intron organization are still unsettled. Genome-scale comparative studies, which can shed light on crucial aspects of eukaryotic evolution, require adequate ...
Adachi +53 more
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Introns: The Functional Benefits of Introns in Genomes [PDF]
Genomics & Informatics, 2015 The intron has been a big biological mystery since it was first discovered in several aspects. First, all of the completely sequenced eukaryotes harbor introns in the genomic structure, whereas no prokaryotes identified so far carry introns. Second, the amount of total introns varies in different species. Third, the length and number of introns vary in
Bong Seok Jo, Sun Shim Choi
doaj +5 more sources
Aberrant splicing of U12-type introns is the hallmark of ZRSR2 mutant myelodysplastic syndrome. [PDF]
Nature Communications, 2015 Somatic mutations in the spliceosome gene ZRSR2-located on the X chromosome-are associated with myelodysplastic syndrome (MDS). ZRSR2 is involved in the recognition of 3'-splice site during the early stages of spliceosome assembly; however, its precise ...
Ganser, Arnold +16 more
core +3 more sources
Frontiers in Genetics, 2012 The intron-exon architecture of many eukaryotic genes raises the intriguing question of whether this unique organization serves any function, or is it simply a result of the spread of functionless introns in eukaryotic genomes. In this review, we show that introns in contemporary species fulfill a broad spectrum of functions, and are involved in ...
Liran eCarmel +2 more
openaire +5 more sources
Memórias do Instituto Oswaldo Cruz, 2018 In Cryptococcus neoformans, nearly all genes are interrupted by small introns. In recent years, genome annotation and genetic analysis have illuminated the major roles these introns play in the biology of this pathogenic yeast. Introns are necessary for gene expression and alternative splicing can regulate gene expression in response to environmental ...
Guilhem Janbon
openaire +9 more sources
Molecular Biotechnology, 2011 Eukaryotic gene expression relies on several complex molecular machineries that act in a highly coordinated fashion. These machineries govern all the different steps of mRNA maturation, from gene transcription and pre-mRNA processing in the nucleus to the export of the mRNA to the cytoplasm and its translation.
Sergio Tisminetzky +3 more
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Intron “sliding” and the diversity of intron positions [PDF]
Proceedings of the National Academy of Sciences, 1997 Alignments of homologous genes typically reveal a great diversity of intron locations, far more than could fit comfortably in a single gene. Thus, a minority of these intron positions could be inherited from a single ancestral gene, but the larger share must be attributed to subsequent events of intron gain or intron “sliding” (movement from one ...
Arlin Stoltzfus +3 more
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Complex exon-intron marking by histone modifications is not determined solely by nucleosome distribution [PDF]
, 2010 It has recently been shown that nucleosome distribution, histone modifications and RNA polymerase II (Pol II) occupancy show preferential association with exons (“exon-intron marking”), linking chromatin structure and function to co-transcriptional ...
A Barski +66 more
core +12 more sources
Intronization, de-intronization and intron sliding are rare in Cryptococcus [PDF]
BMC Evolutionary Biology, 2009 Eukaryotic pre-mRNA gene transcripts are processed by the spliceosome to remove portions of the transcript, called spliceosomal introns. The spliceosome recognizes intron boundaries by the presence of sequence signals (motifs) contained in the actual transcript, thus sequence changes in the genome that affect existing splicing signals or create new ...
openaire +4 more sources
Evidence of widespread degradation of gene control regions in hominid genomes [PDF]
, 2005 Although sequences containing regulatory elements located close to protein-coding genes are often only weakly conserved during evolution, comparisons of rodent genomes have implied that these sequences are subject to some selective constraints ...
Eyre-Walker, Adam +2 more
core +6 more sources