Results 1 to 10 of about 222,325 (351)

Introns: The Functional Benefits of Introns in Genomes [PDF]

Genomics & Informatics, 2015
The intron has been a big biological mystery since it was first discovered in several aspects. First, all of the completely sequenced eukaryotes harbor introns in the genomic structure, whereas no prokaryotes identified so far carry introns.
Bong-Seok Jo, Sun Shim Choi
doaj   +4 more sources

Aberrant splicing of U12-type introns is the hallmark of ZRSR2 mutant myelodysplastic syndrome [PDF]

Nature Communications, 2015
Somatic mutations in the spliceosome gene ZRSR2-located on the X chromosome-are associated with myelodysplastic syndrome (MDS). ZRSR2 is involved in the recognition of 3'-splice site during the early stages of spliceosome assembly; however, its precise ...
Vikas Madan, Aiko Sato-Otsubo, Masashi Sanada   +2 more
exaly   +7 more sources

Plant intron sequences: evidence for distinct groups of introns [PDF]

Nucleic Acids Research, 1988
In vivo and in vitro RNA splicing experiments have demonstrated that the intron splicing machineries are not interchangeable in all organisms. These differences have prevented the efficient in vivo expression of monocot genes containing introns in dicot plants and the in vitro excision of some plant introns in HeLa cell in vitro splicing extracts.
Brian A. Hanley, M. A. Schuler
openalex   +4 more sources

Introns in Cryptococcus [PDF]

Memorias do Instituto Oswaldo Cruz, 2018
In Cryptococcus neoformans, nearly all genes are interrupted by small introns. In recent years, genome annotation and genetic analysis have illuminated the major roles these introns play in the biology of this pathogenic yeast.
Guilhem Janbon
doaj   +6 more sources

In search of lost introns [PDF]

Bioinformatics, 2007
Many fundamental questions concerning the emergence and subsequent evolution of eukaryotic exon-intron organization are still unsettled. Genome-scale comparative studies, which can shed light on crucial aspects of eukaryotic evolution, require adequate ...
Adachi, Aldous, Altschul, Bieri, Blum, Carmel, Collins, Coulombe-Huntington, Csűrös, Csűrös, Devroye, Durbin, Edgar, Felsenstein, Felsenstein, Felsenstein, Friedman, Guindon, Harding, Heard, Hubbard, Igor B. Rogozin, IHBSC, J. Andrew Holey, Jeffares, Kececioglu, Kosakovsky Pond, Larget, Ma, Marchler-Bauer, McDiarmid, McKenzie, Miklós Csűrös, Müller, Nguyen, Nielsen, Nixon, Press, Pruitt, Raible, Rogozin, Rogozin, Rosenberg, Roy, Roy, Roy, Roy, Stamatakis, Steel, Sverdlov, Sverdlov, Tatusov, Vaňácová, Zhang   +53 more
core   +4 more sources

Introns increase gene expression in Caenorhabditis elegans by a mechanism that must be at least partly different than in plants [PDF]

Scientific Reports
The wide diversity of organisms in which introns stimulate gene expression suggests that this is an ancient phenomenon. However, the mechanisms through which introns boost expression remain poorly understood, and the degree the which the action of ...
Alan B. Rose, Aaron Baer, Isaac Shaker, J. Grey Monroe, Ian Korf, Lesilee S. Rose   +5 more
doaj   +2 more sources

Phase distribution of spliceosomal introns: implications for intron origin [PDF]

BMC Evolutionary Biology, 2006
Background The origin of spliceosomal introns is the central subject of the introns-early versus introns-late debate. The distribution of intron phases is non-uniform, with an excess of phase-0 introns.
Yoshihama Maki, Nguyen Hung D, Kenmochi Naoya   +2 more
doaj   +4 more sources

Complex exon-intron marking by histone modifications is not determined solely by nucleosome distribution [PDF]

, 2010
It has recently been shown that nucleosome distribution, histone modifications and RNA polymerase II (Pol II) occupancy show preferential association with exons (“exon-intron marking”), linking chromatin structure and function to co-transcriptional ...
A Barski, A Tyagi, AJ Bannister, Alexander W. Bruce, Anton Wutz, AW Bruce, AW Bruce, B Langmead, B Li, BB Lozzio, BE Bernstein, Christoph M. Koch, CK Lee, CM Koch, Cordelia Langford, David Vetrie, E Allemand, E Batsche, E Birney, EC Forsberg, G Felsenfeld, G Hon, G Nogues, H Tilgner, Ian Dunham, IE Schor, Jackie Bye, JW Larrick, Keith James, Kelly Chiang, KJ Howe, M Allo, M de la Mata, M Yonaha, MC Keogh, MJ Carrozza, N Spies, NA Watkins, ND Heintzman, ND Robson-Dixon, Nicholas A. Watkins, Nicola S. Foad, Nicolas Bonhoure, NJ Park, P Dhami, P Kolasinska-Zwierz, Pawandeep Dhami, Peter Ellis, Peter Saffrey, PG Giresi, PL Nagy, R Andersson, R Landick, RF Luco, RJ Sims, RJ Sims, RK Auerbach, Robert M. Andrews, S Cuddapah, S Nahkuri, S Schwartz, S Schwartz, Shane C. Dillon, T Jenuwein, Willem H. Ouwehand, Y Mito, Z Wang   +66 more
core   +22 more sources

The position of the longest intron is related to biological functions in some human genes

Frontiers in Genetics, 2023
The evidence that introns can influence different levels of transfer of genetic information between DNA and the final product is increasing. Longer first introns were found to be a general property of eukaryotic gene structure and shown to contain a ...
Pavel Dvorak, Pavel Dvorak, Pavel Dvorak, Vojtech Hanicinec, Pavel Soucek, Pavel Soucek   +5 more
doaj   +1 more source

Polymorphisms of mbl gene introns and their association with mbl serum levels in hu sheep [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi, 2019
PCR single-strand conformation polymorphism (SSCP) and DNA sequencing techniques were used to analyze the genetic polymorphism of mannose-binding lectin (MBL) gene 3 introns in Hu sheep.
Mengting ZHAI, Jian MOU, Mengting ZHU, Yanping LIANG, Mingyuan WANG, Zongsheng ZHAO, Hongmei ZHANG   +6 more
doaj   +1 more source