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Introns: The Functional Benefits of Introns in Genomes [PDF]

Genomics & Informatics, 2015
The intron has been a big biological mystery since it was first discovered in several aspects. First, all of the completely sequenced eukaryotes harbor introns in the genomic structure, whereas no prokaryotes identified so far carry introns.
Bong-Seok Jo, Sun Shim Choi
doaj   +4 more sources

Aberrant splicing of U12-type introns is the hallmark of ZRSR2 mutant myelodysplastic syndrome [PDF]

Nature Communications, 2015
Somatic mutations in the spliceosome gene ZRSR2-located on the X chromosome-are associated with myelodysplastic syndrome (MDS). ZRSR2 is involved in the recognition of 3'-splice site during the early stages of spliceosome assembly; however, its precise ...
Vikas Madan, Aiko Sato-Otsubo, Masashi Sanada   +2 more
exaly   +8 more sources

Organellar Introns in Fungi, Algae, and Plants

Cells, 2021
Introns are ubiquitous in eukaryotic genomes and have long been considered as ‘junk RNA’ but the huge energy expenditure in their transcription, removal, and degradation indicate that they may have functional significance and can offer evolutionary ...
Jigeesha Mukhopadhyay, Georg Hausner
doaj   +2 more sources

Introns increase gene expression in Caenorhabditis elegans by a mechanism that must be at least partly different than in plants [PDF]

Scientific Reports
The wide diversity of organisms in which introns stimulate gene expression suggests that this is an ancient phenomenon. However, the mechanisms through which introns boost expression remain poorly understood, and the degree the which the action of ...
Alan B. Rose, Aaron Baer, Isaac Shaker, J. Grey Monroe, Ian Korf, Lesilee S. Rose   +5 more
doaj   +2 more sources

The role of mutation rate variation and genetic diversity in the architecture of human disease [PDF]

, 2013
Background We have investigated the role that the mutation rate and the structure of genetic variation at a locus play in determining whether a gene is involved in disease.
A Hodgkinson, A Hodgkinson, A Kong, Adam Eyre-Walker, B Charlesworth, B Charlesworth, C Park, CJ Pink, CL Chen, FA Kondrashov, G McVicker, H Ellegren, H Huang, I Hellmann, I Hellmann, I. King Jordan, J Maynard Smith, JA Stamatoyannopoulos, JJ Michaelson, KH Wolfe, L Duret, MJ Lercher, MT Maurano, MW Nachman, NG Smith, R Blekhman, RS Hansen, S Tyekucheva, TI Gossmann, Ying Chen Eyre-Walker   +29 more
core   +23 more sources

The position of the longest intron is related to biological functions in some human genes

Frontiers in Genetics, 2023
The evidence that introns can influence different levels of transfer of genetic information between DNA and the final product is increasing. Longer first introns were found to be a general property of eukaryotic gene structure and shown to contain a ...
Pavel Dvorak, Pavel Dvorak, Pavel Dvorak, Vojtech Hanicinec, Pavel Soucek, Pavel Soucek   +5 more
doaj   +1 more source

Can Introns Stabilize Gene Duplication?

Biology, 2022
Gene duplication is considered one of the most important events that determine the evolution of genomes. However, the neo-duplication condition of a given gene is particularly unstable due to recombination events. Several mechanisms have been proposed to
Gioacchino Micheli, Giorgio Camilloni
doaj   +1 more source

Polymorphisms of mbl gene introns and their association with mbl serum levels in hu sheep [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi, 2019
PCR single-strand conformation polymorphism (SSCP) and DNA sequencing techniques were used to analyze the genetic polymorphism of mannose-binding lectin (MBL) gene 3 introns in Hu sheep.
Mengting ZHAI, Jian MOU, Mengting ZHU, Yanping LIANG, Mingyuan WANG, Zongsheng ZHAO, Hongmei ZHANG   +6 more
doaj   +1 more source

Exploring the Relationship between Fusion Genes and MicroRNAs in Cancer

Cells, 2023
Fusion genes are key cancer driver genes that can be used as potential drug targets in precision therapies, and they can also serve as accurate diagnostic and prognostic biomarkers.
Saurav Panicker, Gautham Chengizkhan, Ravi Gor, Ilangovan Ramachandran, Satish Ramalingam   +4 more
doaj   +1 more source

Genome-Wide Analysis of Amino Acid Transporter Gene Family Revealed That the Allele Unique to the Aus Variety Is Associated with Amino Acid Permease 17 (OsAAP17) Amplifies Both the Tiller Count and Yield in Indica Rice (Oryza sativa L.)

Agronomy, 2023
Amino acid transporters (AATs) play a crucial role in facilitating the movement of amino acids across cellular membranes, which is vital for the growth and development of plants.
Itishree Nayak, Bijayalaxmi Sahoo, Chinmay Pradhan, Cayalvizhi Balasubramaniasai, Seenichamy Rathinam Prabhukarthikeyan, Jawahar Lal Katara, Jitendriya Meher, Sang-Min Chung, Abdel-Rhman Z. Gaafar, Mohamed S. Hodhod, Bhagwat Singh Kherawat, Chidambaranathan Parameswaran, Mahipal Singh Kesawat, Sanghamitra Samantaray   +13 more
doaj   +1 more source