Results 21 to 30 of about 137,846 (269)

Defining the location of promoter-associated R-loops at near-nucleotide resolution using bisDRIP-seq

eLife, 2017
R-loops are features of chromatin consisting of a strand of DNA hybridized to RNA, as well as the expelled complementary DNA strand. R-loops are enriched at promoters where they have recently been shown to have important roles in modifying gene ...
Jason G Dumelie, Samie R Jaffrey
doaj   +1 more source

Comparative Genomics Analysis of Ciliates Provides Insights on the Evolutionary History Within “Nassophorea–Synhymenia–Phyllopharyngea” Assemblage

Frontiers in Microbiology, 2019
Ciliated protists (ciliates) are widely used for investigating evolution, mostly due to their successful radiation after their early evolutionary branching.
Bo Pan, Bo Pan, Xiao Chen, Lina Hou, Qianqian Zhang, Zhishuai Qu, Zhishuai Qu, Alan Warren, Miao Miao   +8 more
doaj   +1 more source

The Cancer Spliceome: Reprograming of Alternative Splicing in Cancer

Frontiers in Molecular Biosciences, 2018
Alternative splicing allows for the expression of multiple RNA and protein isoforms from one gene, making it a major contributor to transcriptome and proteome diversification in eukaryotes.
Ettaib El Marabti, Ihab Younis
doaj   +1 more source

Population Genomic Analysis Reveals a Highly Conserved Mitochondrial Genome in Fusarium asiaticum

Frontiers in Microbiology, 2020
Fusarium asiaticum is one of the pivotal members of the Fusarium graminearum species complex (FGSC) causing Fusarium head blight (FHB) on wheat, barley and rice in large parts of Asia.
Meixin Yang, Meixin Yang, Hao Zhang, Theo A. J. van der Lee, Cees Waalwijk, Anne D. van Diepeningen, Jie Feng, Balázs Brankovics, Wanquan Chen   +8 more
doaj   +1 more source

Mitochondrial genomes of the early land plant lineage liverworts (Marchantiophyta): conserved genome structure, and ongoing low frequency recombination

BMC Genomics, 2019
Background In contrast to the highly labile mitochondrial (mt) genomes of vascular plants, the architecture and composition of mt genomes within the main lineages of bryophytes appear stable and invariant.
Shanshan Dong, Chaoxian Zhao, Shouzhou Zhang, Li Zhang, Hong Wu, Huan Liu, Ruiliang Zhu, Yu Jia, Bernard Goffinet, Yang Liu   +9 more
doaj   +1 more source

Analysis of intron sequence features associated with transcriptional regulation in human genes. [PDF]

PLoS ONE, 2012
Although some preliminary work has revealed the potential transcriptional regulatory function of the introns in eukaryotes, additional evidences are needed to support this conjecture.
Huimin Li, Dan Chen, Jing Zhang
doaj   +1 more source

Order of removal of conventional and nonconventional introns from nuclear transcripts of Euglena gracilis. [PDF]

PLoS Genetics, 2018
Nuclear genes of euglenids and marine diplonemids harbor atypical, nonconventional introns which are not observed in the genomes of other eukaryotes. Nonconventional introns do not have the conserved borders characteristic for spliceosomal introns or the
Natalia Gumińska, Magdalena Płecha, Bożena Zakryś, Rafał Milanowski   +3 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Identification of an Exceptionally Long Intron in the HAC1 Gene of Candida parapsilosis

mSphere, 2018
The unfolded protein response (UPR) in the endoplasmic reticulum (ER) is well conserved in eukaryotes from metazoa to yeast. The transcription factor HAC1 is a major regulator of the UPR in many eukaryotes. Deleting HAC1 in the yeast Candida parapsilosis
Elise Iracane, Paul D. Donovan, Mihaela Ola, Geraldine Butler, Linda M. Holland   +4 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source