Results 51 to 60 of about 304,363 (385)

Identification of an Exceptionally Long Intron in the HAC1 Gene of Candida parapsilosis

mSphere, 2018
The unfolded protein response (UPR) in the endoplasmic reticulum (ER) is well conserved in eukaryotes from metazoa to yeast. The transcription factor HAC1 is a major regulator of the UPR in many eukaryotes. Deleting HAC1 in the yeast Candida parapsilosis
Elise Iracane, Paul D. Donovan, Mihaela Ola, Geraldine Butler, Linda M. Holland   +4 more
doaj   +1 more source

Rescue of splicing-mediated intron loss maximizes expression in lentiviral vectors containing the human ubiquitin C promoter. [PDF]

, 2014
Lentiviral vectors almost universally use heterologous internal promoters to express transgenes. One of the most commonly used promoter fragments is a 1.2-kb sequence from the human ubiquitin C (UBC) gene, encompassing the promoter, some enhancers, first
Cooper, Aaron R, Gschweng, Eric H, Kohn, Donald B, Lill, Georgia R   +3 more
core   +1 more source

Transcriptome Analyses of Tumor-Adjacent Somatic Tissues Reveal Genes Co-Expressed with Transposable Elements [PDF]

, 2019
Background: Despite the long-held assumption that transposons are normally only expressed in the germ-line, recent evidence shows that transcripts of transposable element (TE) sequences are frequently found in the somatic cells.
Alberto, Adrian, Chung, Micky, Churchill, Daphnie, Clymer, Cody, Han, Mira V., Jonaid, G. M., Navarro Leija, Omar, Quinton, Sophia, Ross, Austin, Sexton, Corinne E.   +9 more
core   +2 more sources

Group I introns are widespread in archaea

Nucleic Acids Research, 2018
Group I catalytic introns have been found in bacterial, viral, organellar, and some eukaryotic genomes, but not in archaea. All known archaeal introns are bulge-helix-bulge (BHB) introns, with the exception of a few group II introns. It has been proposed
Eric P. Nawrocki, T. A. Jones, S. Eddy
semanticscholar   +1 more source

Stability domains of actin genes and genomic evolution

, 2007
In eukaryotic genes the protein coding sequence is split into several fragments, the exons, separated by non-coding DNA stretches, the introns. Prokaryotes do not have introns in their genome.
A. Dkhissi, B. Alberts, D. Poland, E. Carlon, J. W. Bizzaro, K. A. Marx, M. Lejard Malki, N. J. Dibb, R. Blossey, S. W. Roy   +9 more
core   +1 more source

Mechanism for DNA transposons to generate introns on genomic scales

Nature, 2016
The discovery of introns four decades ago was one of the most unexpected findings in molecular biology. Introns are sequences interrupting genes that must be removed as part of messenger RNA production.
Jason T. Huff, Daniel Zilberman, S. Roy
semanticscholar   +1 more source

In search of lost introns

, 2007
Many fundamental questions concerning the emergence and subsequent evolution of eukaryotic exon-intron organization are still unsettled. Genome-scale comparative studies, which can shed light on crucial aspects of eukaryotic evolution, require adequate ...
Adachi, Aldous, Altschul, Bieri, Blum, Carmel, Collins, Coulombe-Huntington, Csűrös, Csűrös, Devroye, Durbin, Edgar, Felsenstein, Felsenstein, Felsenstein, Friedman, Guindon, Harding, Heard, Hubbard, Igor B. Rogozin, IHBSC, J. Andrew Holey, Jeffares, Kececioglu, Kosakovsky Pond, Larget, Ma, Marchler-Bauer, McDiarmid, McKenzie, Miklós Csűrös, Müller, Nguyen, Nielsen, Nixon, Press, Pruitt, Raible, Rogozin, Rogozin, Rosenberg, Roy, Roy, Roy, Roy, Stamatakis, Steel, Sverdlov, Sverdlov, Tatusov, Vaňácová, Zhang   +53 more
core   +1 more source

Homologous and unique G protein alpha subunits in the nematode Caenorhabditis elegans [PDF]

, 1991
A cDNA corresponding to a known G protein alpha subunit, the alpha subunit of Go (Go alpha), was isolated and sequenced. The predicted amino acid sequence of C. elegans Go alpha is 80-87% identical to other Go alpha sequences.
Lochrie, Michael A., Mendel, Jane E., Simon, Melvin I., Sternberg, Paul W.   +3 more
core   +1 more source

Evolution of group II introns

Mobile DNA, 2015
Present in the genomes of bacteria and eukaryotic organelles, group II introns are an ancient class of ribozymes and retroelements that are believed to have been the ancestors of nuclear pre-mRNA introns.
S. Zimmerly, C. Semper
semanticscholar   +1 more source

Exons, introns and DNA thermodynamics

, 2005
The genes of eukaryotes are characterized by protein coding fragments, the exons, interrupted by introns, i.e. stretches of DNA which do not carry any useful information for the protein synthesis.
A. Stoltzfus, B. Alberts, C. C. F. Blake, D. Poland, D. Poland, Enrico Carlon, K. A. Marx, Mehdi Lejard Malki, N. J. Dibb, Ralf Blossey, W. Gilbert, W. Gilbert   +11 more
core   +1 more source