Results 51 to 60 of about 222,325 (351)
Non-Coding RNA, 2019 The conservation of intronic sequences was studied in the mitochondrial solute carrier (SLC25A*) genes of Zebrafish, Chicken, Mouse and Human. These genes are homologous and the coding sequences have been well conserved throughout Vertebrates, but the ...
Rosa Calvello +4 more
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Population Genomic Analysis Reveals a Highly Conserved Mitochondrial Genome in Fusarium asiaticum
Frontiers in Microbiology, 2020 Fusarium asiaticum is one of the pivotal members of the Fusarium graminearum species complex (FGSC) causing Fusarium head blight (FHB) on wheat, barley and rice in large parts of Asia.
Meixin Yang +8 more
doaj +1 more source
Intron definition in splicing of small Drosophila introns. [PDF]
Molecular and Cellular Biology, 1994 Approximately half of the introns in Drosophila melanogaster are too small to function in a vertebrate and often lack the pyrimidine tract associated with vertebrate 3' splice sites. Here, we report the splicing and spliceosome assembly properties of two such introns: one with a pyrimidine-poor 3' splice site and one with a pyrimidine-rich 3' splice ...
M Talerico, Susan M. Berget
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Improving the Caenorhabditis elegans Genome Annotation Using Machine Learning [PDF]
, 2007 For modern biology, precise genome annotations are of prime importance, as they allow the accurate definition of genic regions. We employ state-of-the-art machine learning methods to assay and improve the accuracy of the genome annotation of the nematode
Bernhard Schölkopf +8 more
core +6 more sources
Nucleic Acids Research, 1987 The sequence information for the splicing process of introns is found in the consensus sequences at the two splice sites. For long introns, of 300 or more nucleotides, the middle regions may provide additional specificity for splicing which can be investigated by defining an adequate quantitative parameter.
Christian J. Michel, Didier Arquès
openaire +4 more sources
Analysis of intron sequence features associated with transcriptional regulation in human genes. [PDF]
PLoS ONE, 2012 Although some preliminary work has revealed the potential transcriptional regulatory function of the introns in eukaryotes, additional evidences are needed to support this conjecture.
Huimin Li, Dan Chen, Jing Zhang
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An orchestrated intron retention program in meiosis controls timely usage of transcripts during germ cell differentiation [PDF]
, 2017 Global transcriptome reprogramming during sper-matogenesis ensures timely expression of factors in each phase of male germ cell differentiation. Sper-matocytes and spermatids require particularly exten-sive reprogramming of gene expression to switch from
Alberdi, Antonio J. +9 more
core +2 more sources
Ecology and EvolutionUnderstanding the forces that shape population genetic structure is fundamental both for understanding evolutionary trajectories and for conservation. Many factors can influence the geographic distribution of genetic variation, and the extent to which ...
Bronwyn A. S. Harkness +3 more
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Dynamics of genomic innovation in the unicellular ancestry of animals
eLife, 2017 Which genomic innovations underpinned the origin of multicellular animals is still an open debate. Here, we investigate this question by reconstructing the genome architecture and gene family diversity of ancestral premetazoans, aiming to date the ...
Xavier Grau-Bové +6 more
doaj +1 more source
FEBS Letters, EarlyView.Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican +7 more
wiley +1 more source