Results 71 to 80 of about 91,240 (240)

Multiparametric Bioresorbable Sensor for Doxorubicin Detection via Molecularly Imprinted Synthetic Receptors

Advanced Science, EarlyView.
A biodegradable molecularly imprinted polymer porous silica sensor enables dual optical readout of doxorubicin via fluorescence and effective optical thickness shifts. The combined transduction mechanisms provide enhanced reliability and quantitative accuracy over clinically relevant concentrations, representing a step toward transient implantable ...
Martina Corsi, Tiziano Di Giulio, Eleonora Vandini, Muhammad Ibrar Asif, Eleonora Daini, Antonietta Vilella, Giuseppina Leo, Alessandra Ottani, Cosimino Malitesta, Daniela Giuliani, Elisabetta Mazzotta, Giuseppe Barillaro   +11 more
wiley   +1 more source

High-flow Oxygen and Nitric Oxide inhalation versus high-flow oxygen alone to prevent intubation in hypoxaemic Respiratory failure (HONOR): a pilot randomised controlled trial protocol

Pilot and Feasibility Studies
Background When conventional oxygen therapies fail, endotracheal intubation and invasive mechanical ventilation are the current standard of care in patients with acute hypoxaemic respiratory failure. However, invasive mechanical ventilation is associated
Luke Churchill, Oystein Tronstad, Karen Hay, Peter J. Thomas, Kiran Shekar   +4 more
doaj   +1 more source

A Conformal Wearable Ultrasound Bioelectronics for Mechanotherapy Reprogramming of Fibroblast Plasticity via Wnt‐FGF10 Axis to Overcome Fibrotic Healing in Urethral Regeneration

Advanced Science, EarlyView.
Fibrotic scarring persistently challenges urethral reconstruction. This study introduces a conformal, wearable ultrasound bioelectronic system that overcomes this by reprogramming fibroblast fate. The device activates a developmental Wnt–FGF10 axis, driving fibroblasts toward a regenerative FGF10+ phenotype that promotes angiogenesis and matrix ...
Mingming Yu, Xingxuan Zhang, Huan Zhang, Jun Wang, Fang Chen, Xiaojun Cai, Yichen Huang, Yuanyi Zheng   +7 more
wiley   +1 more source

Cholesterol Promotes Lung Adenocarcinoma Brain Metastasis by Stabilizing EGFR Protein to Drive EMT, Metabolic Reprogramming, and Premetastatic Niche Formation

Advanced Science, EarlyView.
Cholesterol is revealed as a multitasking fuel for lung adenocarcinoma brain metastasis: it locks EGFR at the membrane to sustain AKT/NF‐κB–driven glycolysis and EMT, loosens the blood–brain barrier by promoting Claudin‐5 loss, and rewires microglia through IL‐4R lipid‐raft–JAK1/STAT6 signaling.
Ying Chen, Xiaoteng Cui, Xinyi Shi, Xu Yang, Yujing Cao, Haolin LI, Qi Zhan, Qixue Wang, Ang Li, Qihong Cheng, Yunfei Wang, Junhu Zhou, MingJie Wang, Chunsheng Kang, Xiaomin Liu   +14 more
wiley   +1 more source

Approach to mechanical ventilation: a simplified approach for a pulmonologist

Monaldi Archives for Chest Disease
Mechanical ventilation is a critical intervention for patients with respiratory failure, providing essential support for oxygenation and ventilation while reducing the work of breathing. It operates through key breath-phase variables: triggering (breath
Pratap Upadhya, Sanjana H S, Harshith R, Vemuri Mahesh Babu, Karthik Balasoupramaniane, Zeenathaalam Nadaf   +5 more
doaj   +1 more source

First Successful Regeneration of a Structurally Native‐Like Colon Using a Bioabsorbable Polymer Sheet

Annals of Gastroenterological Surgery, EarlyView.
This study demonstrated that a bioabsorbable polymer sheet (BAPS) can regenerate approximately half the circumference of the colon with native‐like structure and function in an experimental setting. As the model involved immediate closure after perforation and did not reproduce peritonitis, caution is required when considering clinical applicability ...
Junpei Takashima, Mitsuo Miyazawa, Masayasu Aikawa, Daisuke Fujimoto, Hirotoshi Kobayashi   +4 more
wiley   +1 more source

Acute kidney injury in patients with invasive mechanical ventilation in Guantanamo, 2018-2019

Revista Información Científica, 2020
Introduction: acute kidney injury is a very common complication in the intensive care units, especially in patients with invasive mechanical ventilation. Objective: to characterize acute kidney damage in patients with invasive mechanical ventilation in
Marisela de León-Vidal, José Alfredo Estevan-Soto, Eglhys Granado-Couceiro, Leonardo Fernández-Fernández, Dayana Rodríguez-Reyes   +4 more
doaj  

Predictors and outcome of invasive mechanical ventilation in hospitalized patients with sepsis: data from National Inpatient Sample

Journal of Community Hospital Internal Medicine Perspectives, 2018
Background: Sepsis is a significant cause of mechanical ventilation in hospitalized patients. Objective: The aim of our study was to recognize the demographic and clinical characteristics associated with an increased need for invasive mechanical ...
Rashmi Dhital, Sijan Basnet, Dilli Ram Poudel   +2 more
doaj   +1 more source

Association of a Multimodal Perioperative Care Program With Postoperative Complications in Elderly Patients Undergoing Gastrectomy for Gastric Cancer

Annals of Gastroenterological Surgery, EarlyView.
Implementation of a multimodal perioperative care program and reduction of postoperative complications. ABSTRACT Purpose This retrospective study aimed to assess the clinical effectiveness of a multimodal perioperative care program in reducing postoperative complications in elderly patients undergoing gastrectomy for gastric cancer.
Keiichi Fujiya, Hiroshi Fuseya, Yusuke Yonenaga, Keiko Sanada, Toshimi Inano, Yumi Oguma, Kazuko Nakajima, Chikako Ando, Kumiko Oka, Yusuke Koseki, Kenichiro Furukawa, Yutaka Tanizawa, Masanori Terashima, Etsuro Bando   +13 more
wiley   +1 more source

Effectiveness of non-invasive mechanical ventilation in patients with acute respiratory failure

Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 2018
Background: the predictive factors of success of non-invasive mechanical ventilation in patients with acute respiratory failure are important to define their progress.Objective: to determine the effectiveness of non-invasive mechanical ventilation ...
Gilberto Lázaro Betancourt-Reyes
doaj