Results 61 to 70 of about 1,975,778 (285)

A review of the operational results of the K-ETS (2015–2024)

Energy and Climate Management
Republic of Korea launched its national emissions trading system (K-ETS) in 2015 and is currently in Phase 3 of implementation. As one of the most prominent examples of a successfully established national ETS, the K-ETS covers 73.5% of the country’s ...
Jung-ae Park, Young-hyun Lee, Yong-cheol Park, Hyung-wook Choi   +3 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

The perseverance of Pacioli's goods inventory accounting system [PDF]

, 2011
This paper details sources of the 'undoubtedly strange' (Yamey, 1994a, p.119) system of goods inventory records described in Pacioli’s 1494 bookkeeping treatise and traces the longevity and widespread use of this early perpetual inventory recording (EPIR)
Alexander, D., Alger, I., Benedict, A., Britton, A., Casanova, A., Crittenden, S.W., Dafforne, Dilworth, Edwards, E.O., Edwards, J.R., Foster, Gebsattel, A., Geijsbeek, J.B., Gray, R., Greeley, H.D., Greg Stoner, Hamilton, R., Harris, N., Harrison, W.T., Ireland Commissioners of National Education, Jones, M., Kuter, M., Lambert, Manzoni, D., McLaney, E., Mellis, J., Morrison, C., Oldcastle, H., Pacioli, L., Peragallo, E., Preston, Sombart, W., Turner, Webster, Weetman, P., Wood, F., Wood, F.   +36 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Ecological Restoration of Limestone Tailings in Arid Regions: A Synergistic Substrate–Plant Approach

Biology
In arid regions, the ecological restoration of limestone tailings requires sustainable strategies, yet the synergistic effects of substrate optimization and native plant selection remain poorly understood.
Wei Hou, Dunzhu Pubu, Duoji Bianba, Zeng Dan, Zengtao Jin, Qunzong Gama, Jingjing Hu, Yang Li, Zhuxin Mao   +8 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Forward curves, scarcity and price volatility in oil and natural gas markets [PDF]

, 2009
The role of inventory in explaining the shape of the forward curve and spot price volatility in commodity markets is central in the theory of storage developed by Kaldor [Kaldor, N.
Ané, Brennan, Deaton, Fama, Geman, Geman, Hélyette Geman, Jones, Kaldor, Keynes, Ng, Pindyck, Steve Ohana, Telser, Williams, Williams, Working, Working   +17 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Rediscovery of Lycodon gammiei (Blanford, 1878) (Serpentes, Colubridae) in Xizang, China, with comments on its systematic position [PDF]

ZooKeys
Lycodon gammiei (Blanford, 1878), a rarely encountered species of Asian snake, is characterized by ambiguous systematics and biology. Based on a sole specimen of L.
Fu Shu, Bing Lyu, Keji Guo, Tong Zhang, Xiaoqi Mi, Li Li, Yayong Wu, Peng Guo   +7 more
doaj   +3 more sources