Results 61 to 70 of about 1,818,334 (300)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Interval-cohort designs and bias in the estimation of per-protocol effects: a simulation study
Trials, 2019 Background Randomized trials are considered the gold standard for making inferences about the causal effects of treatments. However, when protocol deviations occur, the baseline randomization of the trial is no longer sufficient to ensure unbiased ...
Jessica G. Young +3 more
doaj +1 more source
The Kaplan–Meier Estimator as an Inverse-Probability-of-Censoring Weighted Average [PDF]
The American Statistician, 2001 The Kaplan-Meier (product-limit) estimator of the survival function of randomly-censored time-to-event data is a central quantity in survival analysis. It is usually introduced as a nonparametric maximum likelihood estimator, or else as the output of an imputation scheme for censored observations such as redistribute-to-the-right or self-consistency ...
Satten G. A., Datta S.
openaire +3 more sources
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
, 2022 Relative risk and adjusted SARs of COVID-19 secondary case using an inverse probability weighting in Pakistani household contacts.
Asghar Khan (9377860) +18 more
core +1 more source
Prediction-Powered Inference with Inverse Probability Weighting
CoRRPrediction-powered inference (PPI) is a recent framework for valid statistical inference with partially labeled data, combining model-based predictions on a large unlabeled set with bias correction from a smaller labeled subset. Building on existing PPI results under covariate shift, we show that PPI rectification admits a direct design-based ...
Jyotishka Datta, Nicholas G. Polson
openaire +2 more sources
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
, 2022 Comparative effectiveness and safety of low-dose and standard-dose apixaban after inverse probability of treatment weighting.
Sylvie Perreault (3574211) +5 more
core +1 more source
Revstat Statistical Journal, 2014 Sometimes it is not feasible to obtain disease status verification for all study subjects. Analysis of only those with disease ascertainment can result in biased estimates of the accuracy (sensitivity, specificity, ROC curve) of a diagnostic test ...
Todd A. Alonzo
doaj +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source