Results 51 to 60 of about 247,571 (298)

A Small Family of Elements with Long Inverted Repeats is Located Near Sites of Developmentally Regulated DNA Rearrangement in \u3cem\u3eTetrahymena thermophila\u3c/em\u3e [PDF]

open access: yes, 1994
Extensive DNA rearrangement occurs during the development of the somatic macronucleus from the germ line micronucleus in ciliated protozoans. The micronuclear junctions and the macronuclear product of a developmentally regulated DNA rearrangement in ...
Berger, Patricia J.   +4 more
core   +1 more source

PinR mediates the generation of reversible population diversity in Streptococcus zooepidemicus [PDF]

open access: yes, 2015
Opportunistic pathogens must adapt to and survive in a wide range of complex ecosystems. Streptococcus zooepidemicus is an opportunistic pathogen of horses and many other animals, including humans.
Andrew S. Waller   +8 more
core   +2 more sources

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

open access: yesFEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang   +9 more
wiley   +1 more source

Complete sequence and comparative analysis of the chloroplast genome of coconut palm (Cocos nucifera). [PDF]

open access: yesPLoS ONE, 2013
Coconut, a member of the palm family (Arecaceae), is one of the most economically important trees used by mankind. Despite its diverse morphology, coconut is recognized taxonomically as only a single species (Cocos nucifera L.).
Ya-Yi Huang   +2 more
doaj   +1 more source

Secondary structures in polyoma DNA [PDF]

open access: yes, 1979
Three reproducible secondary-structure features were observed on single strands of polyoma virus DNA mounted for electron microscopy by the T4 gene 32 protein technique: (i) a hairpin fold-back extending from 92.9 +/- 0.8 to 95.0 +/- 0.7 map units; (ii ...
Davidson, Norman   +2 more
core  

A bioinformatics screen identifies TCF19 as an aggressiveness‐sustaining gene in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Gene expression meta‐analysis in multiple prostate cancer patient cohorts identifies Transcription factor 19 (TCF19) as an aggressiveness‐sustaining gene with prognostic potential. TCF19 is a gene repressed by androgen signaling that sustains core cancer‐related processes such as vascular permeability or tumor growth and metastasis.
Amaia Ercilla   +15 more
wiley   +1 more source

The complete mitochondrial genome of Korean Marchantia polymorpha subsp. ruderalis Bischl. & Boisselier: inverted repeats on mitochondrial genome between Korean and Japanese isolates

open access: yesMitochondrial DNA. Part B. Resources, 2019
Based on previous studies of Marchantia polymorpha subsp. ruderalis chloroplast genomes, few sequence variations were identified. Here, we sequenced complete mitochondrial genome of Korean isolate, named as KDBI00084, for uncovering sequence variations ...
Woochan Kwon, Yongsung Kim, Jongsun Park
doaj   +1 more source

Complete mitogenomes of the chlorophyte green algae Scherffelia dubia and Tetraselmis sp. CCMP 881 (Chlorodendrophyceae)

open access: yesMitochondrial DNA. Part B. Resources, 2020
We report here the first mitogenome sequences for the chlorophyte class Chlorodendrophyceae. The mitogenomes of Tetraselmis sp. CCMP 881 and Scherffelia dubia (SAG 17.86) are 46,904 bp and 78,958 bp long, respectively, but their gene repertoires are ...
Monique Turmel   +3 more
doaj   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

open access: yesMolecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu   +18 more
wiley   +1 more source

Efficient cloning system for construction of gene silencing vectors in Aspergillus niger [PDF]

open access: yes, 2008
An approach based on Gateway recombination technology to efficiently construct silencing vectors was developed for use in the biotechnologically important fungus Aspergillus niger. The transcription activator of xylanolytic and cellulolytic genes XlnR of
Graaff, L.H., de   +3 more
core   +2 more sources

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