Results 81 to 90 of about 239,716 (330)
Molecular Oncology, EarlyView.We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau +11 more
wiley +1 more source
Unique Tandem Repeats in the Inverted Terminal Repeat Regions of Monkeypox Viruses
Microbiology Spectrum, 2023 The different groups of MPXVs contain unique tandem repeats with different copy numbers in the ITR regions, and these repeats may be likely to play a role in the genetic diversity of the virus. Clade IIb (B) MPXV contains 38 and 32 repeats similar to the Tandem repeats reported in the human and rodent genome, respectively.
Perumal Arumugam Desingu +2 more
openaire +2 more sources
Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry
Molecular Oncology, EarlyView.Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson +11 more
wiley +1 more source
Mitochondrial DNA. Part B. Resources, 2019 Abies fansipanensis is an Endangered species in South China with less than 2500 mature trees. In this study, we reported the complete chloroplast genome of A. fansipanensis.
Zhen-Ni Guo +4 more
doaj +1 more source
Nature Communications, 2023 Inverted duplications, also known as foldback inversions, are commonly observed in cancers and are the major class of chromosome rearrangement recovered from yeast cells lacking Mre11 nuclease activity. Foldback priming at DNA double-strand breaks (DSBs)
Amr M. Al-Zain +3 more
doaj +1 more source
Secondary structures in polyoma DNA [PDF]
, 1979 Three reproducible secondary-structure features were observed on single strands of polyoma virus DNA mounted for electron microscopy by the T4 gene 32 protein technique: (i) a hairpin fold-back extending from 92.9 +/- 0.8 to 95.0 +/- 0.7 map units; (ii ...
Davidson, Norman +2 more
core
EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines
Molecular Oncology, EarlyView.The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche +8 more
wiley +1 more source
Next-generation sequencing yields the complete chloroplast genome of Abies Alba
Mitochondrial DNA. Part B. Resources, 2019 Abies alba is native to the mountains of Europe and often used as Christmas trees. In this study, we reported the complete chloroplast genome of A. alba. The complete chloroplast genome is 121,243 bp in length, comprising a large single copy (LSC) region
Guo-Yin Li +9 more
doaj +1 more source
PinR mediates the generation of reversible population diversity in Streptococcus zooepidemicus [PDF]
, 2015 Opportunistic pathogens must adapt to and survive in a wide range of complex ecosystems. Streptococcus zooepidemicus is an opportunistic pathogen of horses and many other animals, including humans.
Andrew S. Waller +8 more
core +1 more source
Potent CRISPR-Cas9 inhibitors from Staphylococcus genomes. [PDF]
, 2020 Anti-CRISPRs (Acrs) are small proteins that inhibit the RNA-guided DNA targeting activity of CRISPR-Cas enzymes. Encoded by bacteriophage and phage-derived bacterial genes, Acrs prevent CRISPR-mediated inhibition of phage infection and can also block ...
Doudna, Jennifer A +5 more
core +3 more sources