Results 41 to 50 of about 743,546 (262)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Molecular Cages as Probes in Indicator Displacement Assays: The Case of Scopolamine Detection
Angewandte Chemie, EarlyView.In this research, we show the concept of molecular cages as probes in indicator displacement assays, focusing on scopolamine detection, a drug often used in drug‐facilitated sexual assaults. Drug sensing occurs via the drug‐induced transformation of non‐emissive [Fluorescein2⊂Cage] complex into [Scopolamine⊂Catenane] and highly emissive free ...
Giovanni Montà‐González +5 more
wiley +2 more sources
The object and the subject in scientific research
Medisur, 2022 This article presents the dialectical unity between the object of study and the research subjects. Because usually, through the universe and the research sample, the subjects to be studied are declared, this work emphasizes the need to explicitly declare
Luis Alberto Corona Martínez +2 more
doaj
Journal of Biomedical Science, 2020 Background Radiographic axial spondyloarthritis (r-axSpA) is a chronic inflammatory form of arthritis in which tumor necrosis factor (TNF)-α, a potent inducer of inflammatory response and a key regulator of innate immunity and of Th1 immune responses ...
Patricia Ruiz-Limon +14 more
doaj +1 more source
Avances de la PET en investigación biomédica [PDF]
, 2002 Publicad
Vaquero López, Juan José
core +2 more sources
Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma
Molecular Oncology, EarlyView.PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga +2 more
wiley +1 more source
Atención Primaria, 2016 Objetivo: Llevar a cabo la adaptación cultural y la validación psicométrica del Summary of Diabetes Self-Care measure (SDSCA) en población española con diabetes mellitus tipo 2. Diseño: Estudio de validación clinimétrica.
Jorge Caro-Bautista +5 more
doaj +1 more source
Brain Sciences, 2021 Background: The prevalence of neural autoantibodies in epilepsy of unknown etiology varies among studies. We aimed to conduct a systematic review and meta-analysis to determine the pooled global prevalence and the prevalence for each antibody. Methods: A
Pablo Cabezudo-García +5 more
doaj +1 more source
Ética de la investigación biomédica [PDF]
, 2007 Las cuestiones éticas al final de la vida pueden parecer más propias del nivel hospitalario, con sus avanzados medios tecnológicos. Sin embargo, las consideraciones éticas sobre la futilidad, proporcionalidad o desproporcionalidad de los tratamientos, el
Magdalena Bello, Jesús
core +1 more source
Variably Protease‐Sensitive Prionopathy: Two New Cases With Motor Neuron‐Dementia Syndrome
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT We describe two patients with variably protease‐sensitive prionopathy (VPSPr) who developed progressive upper motor neuron symptoms, insomnia, behavioral and cognitive decline, compatible with primary lateral sclerosis associated with frontotemporal dementia (FTD).
María Elena Erro +10 more
wiley +1 more source