Results 121 to 130 of about 45,621 (282)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Involution of thyroid hyperplasia
, 1986 The first part of our thesis is a review of the literature. The first chapter deals with the structure and physiology of the thyroid gland; in the second chapter the regulation of thyroid gland is reviewed. The second aprt includes our personal work. In
Hamudi, Salim R.
core
Seeking Stability in China's "Involuted Generation"
The Journal for Undergraduate EthnographyIn recent years, the word “involution” (Nei Juan) has become a popular word in Chinese society to refer to the great competitive pressure young people in China now face in their life such as passing the college entrance examination and searching for a ...
Yuchen Liang
doaj
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Involutive Quantales and Quantale-Enriched Involutive Topological Spaces
Applied Categorical StructuresAbstract In this paper, we provide a comprehensive analysis of involutive quantales, with a particular focus on quantic frames. We extend the axiomatic foundations of quantale-enriched topological spaces to include closure under the anti-homomorphic involution, facilitating a balanced topologization of the ...
Javier Gutiérrez García, Ulrich Höhle
openaire +2 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Equational Theories of Unstable Involution Semigroups
, 2017 It is long known that with respect to the property of having a finitely axiomatizable equational theory, there is no relationship between a general involution semigroup and its semigroup reduct.
Edmond W. H. Lee, Lee, Edmond W. H.
core +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source