Results 1 to 10 of about 91,721 (252)

Swapping the Positions in a Cross-Strand Lateral Ion-Pairing Interaction between Ammonium- and Carboxylate-Containing Residues in a β-Hairpin [PDF]

Molecules, 2021
Cross-strand lateral ion-pairing interactions are important for antiparallel β-sheet stability. Statistical studies suggested that swapping the position of cross-strand lateral residues should not significantly affect the interaction.
Cheng-Hsin Huang, Tong Wai Wong, Chen-Hsu Yu, Jing-Yuan Chang, Shing-Jong Huang, Shou-Ling Huang, Richard P. Cheng   +6 more
doaj   +2 more sources

The Effects of Counter-Ions on Peptide Structure, Activity, and Applications [PDF]

Biomolecules
Peptide drug development has emerged as a prominent area in pharmaceutical research due to its high specificity and therapeutic potential. However, their biological activity, stability, and bioavailability are significantly influenced by interactions ...
Ying Liu, Yi Huang, Lan Yang, Yu Gao, Zheng Jia, Tingting Liu, Baoling Su, Chuyuan Wang, Lili Jin, Dianbao Zhang   +9 more
doaj   +2 more sources

Ion-Pairing Hydrophilic Interaction Chromatography for Impurity Profiling of Therapeutic Phosphorothioated Oligonucleotides. [PDF]

Anal Chem
Therapeutic oligonucleotides (ONs) are short synthetic DNA or RNA strands used to modulate protein expression in disease treatment. Besides the full-length product (FLP), ON samples contain many closely related impurities that must be profiled to ensure drug quality.
Tutiš L, Ferguson PD, Benstead D, Clarke A, Heatherington C, Gripton C, Vanhinsbergh CJ, Somsen GW, Gargano AF.   +8 more
europepmc   +3 more sources

Superalkali–Alkalide Interactions and Ion Pairing in Low-Polarity Solvents [PDF]

Journal of the American Chemical Society, 2021
The nature of anionic alkali metals in solution is traditionally thought to be "gaslike" and unperturbed. In contrast to this noninteracting picture, we present experimental and computational data herein that support ion pairing in alkalide solutions.
René Riedel, Andrew G. Seel, Daniel Malko, Daniel P. Miller, Brendan T. Sperling, Heungjae Choi, Thomas F. Headen, Eva Zurek, Adrian Porch, Anthony Kucernak, Nicholas C. Pyper, Peter P. Edwards, Anthony G. M. Barrett   +12 more
openaire   +6 more sources

The Effects of Charged Amino Acid Side-Chain Length on Diagonal Cross-Strand Interactions between Carboxylate- and Ammonium-Containing Residues in a β-Hairpin

Molecules, 2022
The β-sheet is one of the common protein secondary structures, and the aberrant aggregation of β-sheets is implicated in various neurodegenerative diseases. Cross-strand interactions are an important determinant of β-sheet stability.
Jing-Yuan Chang, Yen-Jin Pan, Pei-Yu Huang, Yi-Ting Sun, Chen-Hsu Yu, Zhi-Jun Ning, Shou-Ling Huang, Shing-Jong Huang, Richard P. Cheng   +8 more
doaj   +1 more source

Diagonal Interactions between Glutamate and Arginine Analogs with Varying Side-Chain Lengths in a β-Hairpin

Molecules, 2023
Cross-strand interactions are important for the stability of β-sheet structures. Accordingly, cross-strand diagonal interactions between glutamate and arginine analogs with varying side-chain lengths were studied in a series of β-hairpin peptides.
Nian-Zhi Li, Chen-Hsu Yu, Jhuan-Yu Wu, Shing-Jong Huang, Shou-Ling Huang, Richard P. Cheng   +5 more
doaj   +1 more source

Advancements in the characterisation of oligonucleotides by high performance liquid chromatography‐mass spectrometry in 2021: A short review

Analytical Science Advances, 2022
The first oligonucleotide therapeutic was approved by the Food and Drug Administration in 1998, and since then, 12 nucleic acids have been commercialised as medicines.
Fabien Hannauer, Rachelle Black, Andrew D. Ray, Eugen Stulz, G. John Langley, Stephen W. Holman   +5 more
doaj   +1 more source

Separation of therapeutic oligonucleotides using ion-pair reversed-phase chromatography based on fundamental separation science

Journal of Chromatography Open, 2023
In recent decades, there has been a trend toward using larger biological molecules as new active pharmaceutical ingredients (APIs) instead of the classical small organic API molecules.
Torgny Fornstedt, Martin Enmark
doaj   +1 more source

Design and optimization of metformin hydrophobic ion pairs for efficient encapsulation in polymeric drug carriers

Scientific Reports, 2022
Loading small molecular weight hydrophilic drugs into polymeric carriers is a challenging task. Metformin hydrochloride (MET) is a highly soluble oral antidiabetic drug of small size and high cationic charge.
Sara I. Abd-El Hafeez, Nermin E. Eleraky, Ehsan Hafez, Sara A. Abouelmagd   +3 more
doaj   +1 more source

Stereosopecificity in [Co(sep)][Co(edta)]Cl₂·2H₂O

Chemistry, 2021
The X-ray structure of racemic [Co(sep)][Co(edta)]Cl2·2H2O is reported and reveals hetero-chiral stereospecificity in the interactions of [Co(sep)]3+ with [Co(edta)]−.
Peter Osvath, Allen Oliver, A. Graham Lappin   +2 more
doaj   +1 more source