Results 21 to 30 of about 4,736,584 (313)

The diverse roles of TMEM16A Ca2+-activated Cl− channels in inflammation

Journal of Advanced Research, 2021
Background: Transmembrane protein 16A (TMEM16A) Ca2+-activated Cl− channels have diverse physiological functions, such as epithelial secretion of Cl− and fluid and sensation of pain.
Weiliang Bai, Mei Liu, Qinghuan Xiao
doaj   +1 more source

The proposed channel-enzyme transient receptor potential melastatin 2 does not possess ADP ribose hydrolase activity

eLife, 2016
Transient Receptor Potential Melastatin 2 (TRPM2) is a Ca2+-permeable cation channel essential for immunocyte activation, insulin secretion, and postischemic cell death.
Iordan Iordanov, Csaba Mihályi, Balázs Tóth, László Csanády   +3 more
doaj   +1 more source

Preventive treatment with ginsenoside Rb1 ameliorates monocrotaline-induced pulmonary arterial hypertension in rats and involves store-operated calcium entry inhibition

Pharmaceutical Biology, 2020
Context Ginsenoside Rb1, the main active ingredient of ginseng, exhibits ex vivo depression of store-operated calcium entry (SOCE) and related vasoconstriction in pulmonary arteries derived from pulmonary hypertension (PH) rats.
Rui-Xing Wang, Rui-Lan He, Hai-Xia Jiao, Run-Tian Zhang, Jing-Yi Guo, Xiao-Ru Liu, Long-Xin Gui, Mo-Jun Lin, Zhi-Juan Wu   +8 more
doaj   +1 more source

How Does Our Knowledge on the Na+/H+ Exchanger NHE1 Obtained by Biochemical and Molecular Analyses Keep up With Its Recent Structure Determination?

Frontiers in Physiology, 2022
Na+/H+ exchangers are membrane transporters conserved in all living systems and therefore are assumed to be amongst the most ancestral molecular devices that equipped the first protocells.
Mallorie Poet, Mallorie Poet, Denis Doyen, Denis Doyen, Denis Doyen, Emmanuel Van Obberghen, Emmanuel Van Obberghen, Emmanuel Van Obberghen, Gisèle Jarretou, Gisèle Jarretou, Yann Bouret, Laurent Counillon, Laurent Counillon   +12 more
doaj   +1 more source

Enzyme activity and selectivity filter stability of ancient TRPM2 channels were simultaneously lost in early vertebrates

eLife, 2019
Transient Receptor Potential Melastatin 2 (TRPM2) is a cation channel important for the immune response, insulin secretion, and body temperature regulation. It is activated by cytosolic ADP ribose (ADPR) and contains a nudix-type motif 9 (NUDT9)-homology
Iordan Iordanov, Balázs Tóth, Andras Szollosi, László Csanády   +3 more
doaj   +1 more source

The Citrus Flavonoid Hesperetin Has an Inadequate Anti-Arrhythmic Profile in the ΔKPQ Na_V1.5 Mutant of the Long QT Type 3 Syndrome

Biomolecules, 2020
Type 3 long QT syndromes (LQT3) are associated with arrhythmogenic gain-of-function mutations in the cardiac voltage-gated Na+ channel (hNaV1.5). The citrus flavanone hesperetin (HSP) was previously suggested as a template molecule to develop new anti ...
Julio Alvarez-Collazo, Alejandro López-Requena, Julio L. Alvarez, Karel Talavera   +3 more
doaj   +1 more source

PPI-MASS: An Interactive Web Server to Identify Protein-Protein Interactions From Mass Spectrometry-Based Proteomics Data

Frontiers in Molecular Biosciences, 2021
Mass spectrometry-based proteomics methods are widely used to identify and quantify protein complexes involved in diverse biological processes. Specifically, tandem mass spectrometry methods represent an accurate and sensitive strategy for identifying ...
Mariela González-Avendaño, Mariela González-Avendaño, Simón Zúñiga-Almonacid, Simón Zúñiga-Almonacid, Simón Zúñiga-Almonacid, Ian Silva, Ian Silva, Boris Lavanderos, Boris Lavanderos, Felipe Robinson, Felipe Robinson, Roberto Rosales-Rojas, Roberto Rosales-Rojas, Fabio Durán-Verdugo, Wendy González, Wendy González, Mónica Cáceres, Mónica Cáceres, Oscar Cerda, Oscar Cerda, Ariela Vergara-Jaque, Ariela Vergara-Jaque   +21 more
doaj   +1 more source

Obligate coupling of CFTR pore opening to tight nucleotide-binding domain dimerization

eLife, 2016
In CFTR, the chloride channel mutated in cystic fibrosis (CF) patients, ATP-binding-induced dimerization of two cytosolic nucleotide binding domains (NBDs) opens the pore, and dimer disruption following ATP hydrolysis closes it.
Csaba Mihályi, Beáta Töröcsik, László Csanády   +2 more
doaj   +1 more source

Lipid-Centric Approaches in Combating Infectious Diseases: Antibacterials, Antifungals and Antivirals with Lipid-Associated Mechanisms of Action

Antibiotics, 2023
One of the global challenges of the 21st century is the increase in mortality from infectious diseases against the backdrop of the spread of antibiotic-resistant pathogenic microorganisms.
Olga S. Ostroumova, Svetlana S. Efimova
doaj   +1 more source

The TRPM2 ion channel is required for sensitivity to warmth

Nature, 2016
Thermally activated ion channels are known to detect the entire thermal range from extreme heat (TRPV2), painful heat (TRPV1, TRPM3 and ANO1), non-painful warmth (TRPV3 and TRPV4) and non-painful coolness (TRPM8) through to painful cold (TRPA1).
Chun-Hsiang Tan, P. McNaughton
semanticscholar   +1 more source