Results 21 to 30 of about 4,602,690 (366)

Practical challenges in data‐driven interpolation: Dealing with noise, enforcing stability, and computing realizations

International Journal of Adaptive Control and Signal Processing, EarlyView., 2023
Summary In this contribution, we propose a detailed study of interpolation‐based data‐driven methods that are of relevance in the model reduction and also in the systems and control communities. The data are given by samples of the transfer function of the underlying (unknown) model, that is, we analyze frequency‐response data.
Quirin Aumann, Ion Victor Gosea
wiley   +1 more source

Functional expression of CLIFAHDD and IHPRF pathogenic variants of the NALCN channel in neuronal cells reveals both gain- and loss-of-function properties

Scientific Reports, 2019
The excitability of neurons is tightly dependent on their ion channel repertoire. Among these channels, the leak sodium channel NALCN plays a crucial role in the maintenance of the resting membrane potential.
Malik Bouasse, Hathaichanok Impheng, Zoe Servant, Philippe Lory, Arnaud Monteil   +4 more
doaj   +1 more source

Estimating the true stability of the prehydrolytic outward-facing state in an ABC protein

eLife, 2023
CFTR, the anion channel mutated in cystic fibrosis patients, is a model ABC protein whose ATP-driven conformational cycle is observable at single-molecule level in patch-clamp recordings.
Márton A Simon, Iordan Iordanov, Andras Szollosi, László Csanády   +3 more
doaj   +1 more source

VAMP7 regulates constitutive membrane incorporation of the cold-activated channel TRPM8

Nature Communications, 2016
The temperature-sensitive TRPM8 channel is essential for cold sensing and has been linked to pathological cold hypersensitivity. Here, the authors find TRPM8 insertion in the cell membrane is mediated by VAMP7 following atypical LAMP1-containing vesicle ...
Debapriya Ghosh, Silvia Pinto, Lydia Danglot, Ine Vandewauw, Andrei Segal, Nele Van Ranst, Melissa Benoit, Annelies Janssens, Rudi Vennekens, Pieter Vanden Berghe, Thierry Galli, Joris Vriens, Thomas Voets   +12 more
doaj   +1 more source

Activity-dependent regulation of T-type calcium channels by submembrane calcium ions

eLife, 2017
Voltage-gated Ca2+ channels are involved in numerous physiological functions and various mechanisms finely tune their activity, including the Ca2+ ion itself.
Magali Cazade, Isabelle Bidaud, Philippe Lory, Jean Chemin   +3 more
doaj   +1 more source

How Does Our Knowledge on the Na+/H+ Exchanger NHE1 Obtained by Biochemical and Molecular Analyses Keep up With Its Recent Structure Determination?

Frontiers in Physiology, 2022
Na+/H+ exchangers are membrane transporters conserved in all living systems and therefore are assumed to be amongst the most ancestral molecular devices that equipped the first protocells.
Mallorie Poet, Mallorie Poet, Denis Doyen, Denis Doyen, Denis Doyen, Emmanuel Van Obberghen, Emmanuel Van Obberghen, Emmanuel Van Obberghen, Gisèle Jarretou, Gisèle Jarretou, Yann Bouret, Laurent Counillon, Laurent Counillon   +12 more
doaj   +1 more source

Structure of the TRPV1 ion channel determined by electron cryo-microscopy

Nature, 2013
Transient receptor potential (TRP) channels are sensors for a wide range of cellular and environmental signals, but elucidating how these channels respond to physical and chemical stimuli has been hampered by a lack of detailed structural information ...
M. Liao, E. Cao, D. Julius, Yifan Cheng
semanticscholar   +1 more source

Lipid ion channels [PDF]

Biophysical Chemistry, 2010
Review
openaire   +5 more sources

Ion Channels of Nociception [PDF]

International Journal of Molecular Sciences, 2020
The special issue “Ion Channels of Nociception” contains 13 articles published by 73 authors from different countries united by the main focusing on the peripheral mechanisms of pain. The content covers the mechanisms of neuropathic, inflammatory, and dental pain as well as pain in migraine and diabetes, nociceptive roles of P2X3, ASIC, Piezo and TRP ...
openaire   +3 more sources

The proposed channel-enzyme transient receptor potential melastatin 2 does not possess ADP ribose hydrolase activity

eLife, 2016
Transient Receptor Potential Melastatin 2 (TRPM2) is a Ca2+-permeable cation channel essential for immunocyte activation, insulin secretion, and postischemic cell death.
Iordan Iordanov, Csaba Mihályi, Balázs Tóth, László Csanády   +3 more
doaj   +1 more source