Results 11 to 20 of about 2,488,331 (299)
Central cavity dehydration as a gating mechanism of potassium channels
Nature Communications, 2023 The hydrophobic gating model, in which ion permeation is inhibited by the hydrophobicity, rather than a physical occlusion of the nanopore, functions in various ion channels including potassium channels.
Ruo-Xu Gu, Bert L. de Groot
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Ion channels gated by heat [PDF]
Proceedings of the National Academy of Sciences, 1999 All animals need to sense temperature to avoid hostile environments and to regulate their internal homeostasis. A particularly obvious example is that animals need to avoid damagingly hot stimuli. The mechanisms by which temperature is sensed have until recently been mysterious, but in the last couple of years, we have begun to understand how ...
Cesare P. +3 more
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Frontiers in Cell and Developmental Biology, 2022 The senses of proprioception, touch, hearing, and blood pressure on mechanosensitive ion channels that transduce mechanical stimuli with high sensitivity and speed. This conversion process is usually called mechanotransduction.
Yu-Chia Chuang +3 more
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Voltage Gated Lipid Ion Channels [PDF]
Biophysical Journal, 2013 10 pages, 7 figures - Strongly revised version compared to first version.
Blicher, Andreas +1 more
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A new polymodal gating model of the proton-activated chloride channel.
PLoS Biology, 2023 The proton-activated chloride (PAC) channel plays critical roles in ischemic neuron death, but its activation mechanisms remain elusive. Here, we investigated the gating of PAC channels using its novel bifunctional modulator C77304.
Piao Zhao +13 more
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Bubbles, Gating, and Anesthetics in Ion Channels [PDF]
Biophysical Journal, 2008 We suggest that bubbles are the bistable hydrophobic gates responsible for the on-off transitions of single channel currents. In this view, many types of channels gate by the same physical mechanism-dewetting by capillary evaporation-but different types of channels use different sensors to modulate hydrophobic properties of the channel wall and thereby
Roth, R. +3 more
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Theoretical implication of liganding reactions in axonal sodium channel gating [PDF]
, 1980 Dorogi PL, Neumann E. Theoretical implication of liganding reactions in axonal sodium channel gating. Neurochemistry International. 1980;2:45-51.Mathematical simulation models for measured permeability properties of axonal Na+ channels point to the ...
Dorogi, Peter L., Neumann, Eberhard
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PLoS Computational Biology, 2020 Understanding the gating mechanism of ion channel proteins is key to understanding the regulation of cell signaling through these channels. Channel opening and closing are regulated by diverse environmental factors that include temperature, electrical ...
Juhwan Lee +3 more
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Hydrophobic Gating in Ion Channels
Journal of Molecular Biology, 2015 Biological ion channels are nanoscale transmembrane pores. When water and ions are enclosed within the narrow confines of a sub-nanometer hydrophobic pore, they exhibit behavior not evident from macroscopic descriptions. At this nanoscopic level, the unfavorable interaction between the lining of a hydrophobic pore and water may lead to stochastic ...
Aryal, P, Sansom, MS, Tucker, S
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Molecular mechanisms of the coupling of gating to voltage sensing in transmembrane proteins [PDF]
, 2014 Voltage gated potassium ion (Kv) channels regulate action potentials of the nervous system by responding to changes in transmembrane voltage, enabling K+ transport across the membrane to restore cells to their resting potential.
Starek, Greg
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