Results 31 to 40 of about 2,488,331 (299)

Transcending Markov: non-Markovian rate processes of thermosensitive TRP ion channels

Royal Society Open Science, 2023
The Markov state model (MSM) is a popular theoretical tool for describing the hierarchy of time scales involved in the function of many proteins especially ion channel gating. An MSM is a particular case of the general non-Markovian model, where the rate
Yuval Ben-Abu, Stephen J Tucker, Sonia Contera   +2 more
doaj   +1 more source

Gating Transition of Pentameric Ligand-Gated Ion Channels [PDF]

Biophysical Journal, 2009
Pentameric ligand-gated ion channels are an important family of membrane proteins and play key roles in physiological processes, including signal transduction at chemical synapses. Here, we study the conformational changes associated with the opening and closing of the channel pore.
Zhu, F., Hummer, G. ; https://orcid.org/0000-0001-7768-746X   +1 more
openaire   +3 more sources

The response of the tandem pore potassium channel TASK-3 (K2P9.1) to voltage : gating at the cytoplasmic mouth [PDF]

, 2009
Although the tandem pore potassium channel TASK-3 is thought to open and shut at its selectivity filter in response to changes of extracellular pH, it is currently unknown whether the channel also shows gating at its inner, cytoplasmic mouth through ...
Feng, J. F., Puja R. Mehta, Sutcliffe, M. J., M. J. Sutcliffe, Mehta, Puja R., Stanfield, P. R., Stanfield, Peter R., Stansfeld, P. J., Feng, J.F., Sutcliffe, M.J., Vavoulis, Dimitris V., Mehta, Puja, R., Vavoulis, D. V., Ashmole, I., Stansfeld, P.J., Feng, Jianfeng, Stansfeld, Phillip J., I. Ashmole, J. F. Feng, P. J. Stansfeld, Vavoulis, D.V., D. V. Vavoulis, P. R. Stanfield, Stanfield, P.R.   +23 more
core   +1 more source

Stochastic ion channel gating in dendritic neurons: morphology dependence and probabilistic synaptic activation of dendritic spikes.

PLoS Computational Biology, 2010
Neuronal activity is mediated through changes in the probability of stochastic transitions between open and closed states of ion channels. While differences in morphology define neuronal cell types and may underlie neurological disorders, very little is ...
Robert C Cannon, Cian O'Donnell, Matthew F Nolan   +2 more
doaj   +1 more source

An Unorthodox Mechanism Underlying Voltage Sensitivity of TRPV1 Ion Channel

Advanced Science, 2020
While the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1) channel is a polymodal nociceptor for heat, capsaicin, and protons, the channel's responses to each of these stimuli are profoundly regulated by membrane potential, damping or ...
Fan Yang, Lizhen Xu, Bo Hyun Lee, Xian Xiao, Vladimir Yarov‐Yarovoy, Jie Zheng   +5 more
doaj   +1 more source

Piezo’s membrane footprint and its contribution to mechanosensitivity

eLife, 2018
Piezo1 is an ion channel that gates open when mechanical force is applied to a cell membrane, thus allowing cells to detect and respond to mechanical stimulation.
Christoph A Haselwandter, Roderick MacKinnon   +1 more
doaj   +1 more source

The selectivity, voltage-dependence and acid sensitivity of the tandem pore potassium channel TASK-1 : contributions of the pore domains [PDF]

, 2007
We have investigated the contribution to ionic selectivity of residues in the selectivity filter and pore helices of the P1 and P2 domains in the acid sensitive potassium channel TASK-1.
Sutcliffe, M. J., M. J. Sutcliffe, Stanfield, P. R., Stanfield, Peter R., Stansfeld, P. J., Yuill, K. H., Ashmole, I., Yuill, K.H., Stansfeld, P.J., Stansfeld, Phillip J., I. Ashmole, P. J. Stansfeld, K. H. Yuill, P. R. Stanfield, Stanfield, P.R.   +14 more
core   +1 more source

A biomimetic chiral-driven ionic gate constructed by pillar[6]arene-based host–guest systems

Nature Communications, 2018
Uptake and release of glucose is regulated by glucose-sensitive ion channels, but complexity of the system impedes investigation of the gating behavior under physiological conditions.
Yue Sun, Fan Zhang, Jiaxin Quan, Fei Zhu, Wei Hong, Junkai Ma, Huan Pang, Yao Sun, Demei Tian, Haibing Li   +9 more
doaj   +1 more source

Optical control of PIEZO1 channels

Nature Communications, 2023
PIEZO proteins are large, mechanically-activated trimeric ion channels. Here the authors report a light-gated mouse PIEZO1 channel, mOP1, whereby an azobenzene-based photoswitch covalently localised at the extracellular apex of a transmembrane helix ...
Francisco Andrés Peralta, Mélaine Balcon, Adeline Martz, Deniza Biljali, Federico Cevoli, Benoit Arnould, Antoine Taly, Thierry Chataigneau, Thomas Grutter   +8 more
doaj   +1 more source

Polyunsaturated fatty acids modify the gating of Kv channels

Frontiers in Pharmacology, 2012
Polyunsaturated fatty acids (PUFAs) have been reported to exhibit antiarrhythmic properties, which are attributed to their capability to modulate ion channels.
Cristina eMoreno, Alvaro eMacias, Angela ePrieto, Alicia ede la Cruz, Carmen eValenzuela   +4 more
doaj   +1 more source