Effects of ionic strength on gating and permeation of TREK-2 K2P channels.
PLoS ONE, 2021 In addition to the classical voltage-dependent behavior mediated by the voltage-sensing-domains (VSD) of ion channels, a growing number of voltage-dependent gating behaviors are being described in channels that lack canonical VSDs.
Linus J Conrad +2 more
doaj +1 more source
Flexibility of the N-Terminal mVDAC1 Segment Controls the Channel’s Gating Behavior [PDF]
, 2012 Since the solution of the molecular structures of members of the voltage dependent anion channels (VDACs), the N-terminal α-helix has been the main focus of attention, since its strategic location, in combination with its putative conformational ...
Grosse, Wolfgang +23 more
core +2 more sources
Mechanistic Insight into Subunit Stoichiometry for KIR Channel Gating: Ligand Binding, Gating, Binding-Gating Coupling, Coordination, and Cooperativity [PDF]
, 2005 Ligand-gated ion channels couple intra- and extracellular chemical signals to cellular excitability. In response to a specific ligand, these channels change their permeability to certain ions by opening or closing their ion conductive pathway, a ...
Wang, Runping
core +1 more source
Studies of NMDA receptor function and stoichiometry with truncated and tandem subunits [PDF]
, 2003 The subunits that compose eukaryotic glutamate ion channel receptors have three transmembrane domains (TMs) and terminate with intracellular tails that are important for controlling channel expression and localization.
Schorge, S. +3 more
core +1 more source
Energetic contributions to channel gating of residues in the muscle nicotinic receptor β1 subunit. [PDF]
PLoS ONE, 2013 In the pentameric ligand-gated ion channel family, transmitter binds in the extracellular domain and conformational changes result in channel opening in the transmembrane domain.
Gustav Akk +5 more
doaj +1 more source
Single-Molecule Studies of Ion Channels Expressing Unnatural Amino Acids [PDF]
, 2011 The nicotinic acetylcholine receptors are pentameric ligand-gated ion channels that mediate fast synaptic transmission in the brain and peripheral nervous system.
Shanata, Jai Anand Pattur
core +1 more source
Implications of stochastic ion channel gating and dendritic spine plasticity for neural information processing and storage [PDF]
, 2012 On short timescales, the brain represents, transmits, and processes information through the electrical activity of its neurons. On long timescales, the brain stores information in the strength of the synaptic connections between its neurons.
O'Donnell, Cian
core +3 more sources
eLife, 2021 Ligand-gated ion channels conduct currents in response to chemical stimuli, mediating electrochemical signaling in neurons and other excitable cells.
Cathrine Bergh +3 more
doaj +1 more source
Conformational changes in the catalytically inactive nucleotide-binding site of CFTR. [PDF]
, 2013 A central step in the gating of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel is the association of its two cytosolic nucleotide-binding domains (NBDs) into a head-to-tail dimer, with two nucleotides bound at the ...
Mihályi Csaba +19 more
core +1 more source
Ligand recognition and gating mechanism through three ligand-binding sites of human TRPM2 channel
eLife, 2019 TRPM2 is critically involved in diverse physiological processes including core temperature sensing, apoptosis, and immune response. TRPM2’s activation by Ca2+ and ADP ribose (ADPR), an NAD+-metabolite produced under oxidative stress and neurodegenerative
Yihe Huang, Becca Roth, Wei Lü, Juan Du
doaj +1 more source