Results 31 to 40 of about 2,330,072 (298)

Conformational changes in the catalytically inactive nucleotide-binding site of CFTR. [PDF]

, 2013
A central step in the gating of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel is the association of its two cytosolic nucleotide-binding domains (NBDs) into a head-to-tail dimer, with two nucleotides bound at the ...
Mihályi Csaba, Vergani P, Töröcsik, B, Csanády, László, Csanády László, Mihályi, C, Csaba Mihályi, Paola Vergani, Vergani, Paola, Beáta Töröcsik, Szollosi, A, László Csanády, Szőllősi, András, Szöllősi András, Törőcsik, Beáta, Mihályi, Csaba, Andras Szollosi, Vergani, P, Törőcsik Beáta, Csanády, L   +19 more
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The response of the tandem pore potassium channel TASK-3 (K2P9.1) to voltage : gating at the cytoplasmic mouth [PDF]

, 2009
Although the tandem pore potassium channel TASK-3 is thought to open and shut at its selectivity filter in response to changes of extracellular pH, it is currently unknown whether the channel also shows gating at its inner, cytoplasmic mouth through ...
Feng, J. F., Puja R. Mehta, Sutcliffe, M. J., M. J. Sutcliffe, Mehta, Puja R., Stanfield, P. R., Stanfield, Peter R., Stansfeld, P. J., Feng, J.F., Sutcliffe, M.J., Vavoulis, Dimitris V., Mehta, Puja, R., Vavoulis, D. V., Ashmole, I., Stansfeld, P.J., Feng, Jianfeng, Stansfeld, Phillip J., I. Ashmole, J. F. Feng, P. J. Stansfeld, Vavoulis, D.V., D. V. Vavoulis, P. R. Stanfield, Stanfield, P.R.   +23 more
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Gating Transition of Pentameric Ligand-Gated Ion Channels [PDF]

Biophysical Journal, 2009
Pentameric ligand-gated ion channels are an important family of membrane proteins and play key roles in physiological processes, including signal transduction at chemical synapses. Here, we study the conformational changes associated with the opening and closing of the channel pore.
Zhu, F., Hummer, G. ; https://orcid.org/0000-0001-7768-746X   +1 more
openaire   +3 more sources

Single-Molecule Studies of Ion Channels Expressing Unnatural Amino Acids [PDF]

, 2011
The nicotinic acetylcholine receptors are pentameric ligand-gated ion channels that mediate fast synaptic transmission in the brain and peripheral nervous system.
Shanata, Jai Anand Pattur
core   +1 more source

Palmitoylation of Voltage-Gated Ion Channels

International Journal of Molecular Sciences, 2022
Protein lipidation is one of the most common forms of posttranslational modification. This alteration couples different lipids, such as fatty acids, phospho- and glycolipids and sterols, to cellular proteins. Lipidation regulates different aspects of the protein’s physiology, including structure, stability and affinity for cellular membranes and ...
Silvia Cassinelli, Carla Viñola-Renart, Anna Benavente-Garcia, María Navarro-Pérez, Jesusa Capera, Antonio Felipe   +5 more
openaire   +2 more sources

Sodium channel inactivation kinetics of rat sensory and motor nerve fibres and their modulation by glutathione [PDF]

, 1993
Na+ channel currents of rat motor and sensory nerve fibres were studied with the patch-clamp technique on enzymatically demyelinated axons. Differences between motor and sensory fibres in multi-channel inactivation kinetics and the gating of late single ...
Quasthoff, Stefan, Mitrović, N., Grafe, Peter   +2 more
core   +1 more source

Hydrophobic Gating in Ion Channels

Journal of Molecular Biology, 2015
Biological ion channels are nanoscale transmembrane pores. When water and ions are enclosed within the narrow confines of a sub-nanometer hydrophobic pore, they exhibit behavior not evident from macroscopic descriptions. At this nanoscopic level, the unfavorable interaction between the lining of a hydrophobic pore and water may lead to stochastic ...
Aryal, P, Sansom, MS, Tucker, S
openaire   +3 more sources

Optical control of an ion channel gate [PDF]

Proceedings of the National Academy of Sciences, 2013
Significance Engineered light-sensitive ion channels offer the opportunity to govern electrical activity of neurons. To date, developed strategies have relied on specific actions on either ligand-binding or permeation pathways. Here we developed a unique and versatile method, in which the gating machinery of an ATP-activated channel ...
Lemoine, Damien, Habermacher, Chloé, Martz, Adeline, Méry, Pierre-François, Bouquier, Nathalie, Diverchy, Fanny, Taly, Antoine, Rassendren, François, Specht, Alexandre, Grutter, Thomas   +9 more
openaire   +2 more sources

A nomenclature for ligand-gated ion channels [PDF]

Neuropharmacology, 2009
The ligand-gated ion channels that participate in fast synaptic transmission comprise the nicotinic acetylcholine, 5-hydroxytryptamine3 (5-HT3), gamma-aminobutyric acidA (GABA(A)), glycine, ionotropic glutamate and P2X receptor families. A consistent and systematic nomenclature for the individual subunits that comprise these receptors and the receptors
Collingridge, GL, Olsen, RW, Peters, J, Spedding, M   +3 more
openaire   +3 more sources

Molecular simulations of ion channel gating [PDF]

, 2022
Ion channels are membrane proteins that facilitate ion permeation across the membrane down the concentration gradient. Recently, many structures of the ion channels were solved using cryo-electron microscopy.
Pipatpolkai, Tanadet
core   +1 more source