Results 41 to 50 of about 43,122 (263)

A biomimetic chiral-driven ionic gate constructed by pillar[6]arene-based host–guest systems

Nature Communications, 2018
Uptake and release of glucose is regulated by glucose-sensitive ion channels, but complexity of the system impedes investigation of the gating behavior under physiological conditions.
Yue Sun, Fan Zhang, Jiaxin Quan, Fei Zhu, Wei Hong, Junkai Ma, Huan Pang, Yao Sun, Demei Tian, Haibing Li   +9 more
doaj   +1 more source

Polyunsaturated fatty acids modify the gating of Kv channels

Frontiers in Pharmacology, 2012
Polyunsaturated fatty acids (PUFAs) have been reported to exhibit antiarrhythmic properties, which are attributed to their capability to modulate ion channels.
Cristina eMoreno, Alvaro eMacias, Angela ePrieto, Alicia ede la Cruz, Carmen eValenzuela   +4 more
doaj   +1 more source

Site-directed spin labeling reveals pentameric ligand-gated ion channel gating motions. [PDF]

PLoS Biology, 2013
Pentameric ligand-gated ion channels (pLGICs) are neurotransmitter-activated receptors that mediate fast synaptic transmission. In pLGICs, binding of agonist to the extracellular domain triggers a structural rearrangement that leads to the opening of an ...
Cosma D Dellisanti, Borna Ghosh, Susan M Hanson, James M Raspanti, Valerie A Grant, Gaoussou M Diarra, Abby M Schuh, Kenneth Satyshur, Candice S Klug, Cynthia Czajkowski   +9 more
doaj   +1 more source

Palmitoylation of Voltage-Gated Ion Channels

International Journal of Molecular Sciences, 2022
Protein lipidation is one of the most common forms of posttranslational modification. This alteration couples different lipids, such as fatty acids, phospho- and glycolipids and sterols, to cellular proteins. Lipidation regulates different aspects of the protein’s physiology, including structure, stability and affinity for cellular membranes and ...
Silvia Cassinelli, Carla Viñola-Renart, Anna Benavente-Garcia, María Navarro-Pérez, Jesusa Capera, Antonio Felipe   +5 more
openaire   +2 more sources

Distinct gating mechanisms revealed by the structures of a multi-ligand gated K+ channel

eLife, 2012
The gating ring-forming RCK domain regulates channel gating in response to various cellular chemical stimuli in eukaryotic Slo channel families and the majority of ligand-gated prokaryotic K+ channels and transporters.
Chunguang Kong, Weizhong Zeng, Sheng Ye, Liping Chen, David Bryant Sauer, Yeeling Lam, Mehabaw Getahun Derebe, Youxing Jiang   +7 more
doaj   +1 more source

A nomenclature for ligand-gated ion channels [PDF]

Neuropharmacology, 2009
The ligand-gated ion channels that participate in fast synaptic transmission comprise the nicotinic acetylcholine, 5-hydroxytryptamine3 (5-HT3), gamma-aminobutyric acidA (GABA(A)), glycine, ionotropic glutamate and P2X receptor families. A consistent and systematic nomenclature for the individual subunits that comprise these receptors and the receptors
Collingridge, GL, Olsen, RW, Peters, J, Spedding, M   +3 more
openaire   +3 more sources

A binding-block ion selective mechanism revealed by a Na/K selective channel

Protein & Cell, 2017
Mechanosensitive (MS) channels are extensively studied membrane protein for maintaining intracellular homeostasis through translocating solutes and ions across the membrane, but its mechanisms of channel gating and ion selectivity are largely unknown ...
Jie Yu, Bing Zhang, Yixiao Zhang, Cong-qiao Xu, Wei Zhuo, Jingpeng Ge, Jun Li, Ning Gao, Yang Li, Maojun Yang   +9 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Printed Integrated Logic Circuits Based on Chitosan‐Gated Organic Transistors for Future Edible Systems

Advanced Functional Materials, EarlyView.
Edible electronics needs integrated logic circuits for computation and control. This work presents a potentially edible printed chitosan‐gated transistor with a design optimized for integration in circuits. Its implementation in integrated logic gates and circuits operating at low voltage (0.7 V) is demonstrated, as well as the compatibility with an ...
Giulia Coco, Valerio Francesco Annese, Valerio Galli, Ilaria Penna, Debora Russo, Marina Veronesi, Rita Scarpelli, Stefania Sabella, Mario Caironi   +8 more
wiley   +1 more source

Molecular mechanism of GIRK2 channel gating modulated by cholesteryl hemisuccinate

Frontiers in Physiology
Cholesterol, an essential lipid of cell membranes, regulates G protein-gated inwardly rectifying potassium (GIRK) channel activity. Previous studies have shown that cholesterol activates GIRK2 homotetrameric channels, which are expressed in dopaminergic ...
Meng Cui, Meng Cui, Yongcheng Lu, Xinyi Ma, Diomedes E. Logothetis, Diomedes E. Logothetis, Diomedes E. Logothetis, Diomedes E. Logothetis, Diomedes E. Logothetis   +8 more
doaj   +1 more source