Results 21 to 30 of about 43,122 (263)
Ion channels gated by heat [PDF]
Proceedings of the National Academy of Sciences, 1999 All animals need to sense temperature to avoid hostile environments and to regulate their internal homeostasis. A particularly obvious example is that animals need to avoid damagingly hot stimuli. The mechanisms by which temperature is sensed have until recently been mysterious, but in the last couple of years, we have begun to understand how ...
Cesare P. +3 more
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Interplay between Gating and Block of Ligand-Gated Ion Channels
Brain Sciences, 2020 Drugs that inhibit ion channel function by binding in the channel and preventing current flow, known as channel blockers, can be used as powerful tools for analysis of channel properties.
Matthew B. Phillips +2 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2022 The senses of proprioception, touch, hearing, and blood pressure on mechanosensitive ion channels that transduce mechanical stimuli with high sensitivity and speed. This conversion process is usually called mechanotransduction.
Yu-Chia Chuang +3 more
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Voltage Gated Lipid Ion Channels [PDF]
Biophysical Journal, 2013 10 pages, 7 figures - Strongly revised version compared to first version.
Blicher, Andreas +1 more
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A new polymodal gating model of the proton-activated chloride channel.
PLoS Biology, 2023 The proton-activated chloride (PAC) channel plays critical roles in ischemic neuron death, but its activation mechanisms remain elusive. Here, we investigated the gating of PAC channels using its novel bifunctional modulator C77304.
Piao Zhao +13 more
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Bubbles, Gating, and Anesthetics in Ion Channels [PDF]
Biophysical Journal, 2008 We suggest that bubbles are the bistable hydrophobic gates responsible for the on-off transitions of single channel currents. In this view, many types of channels gate by the same physical mechanism-dewetting by capillary evaporation-but different types of channels use different sensors to modulate hydrophobic properties of the channel wall and thereby
Roth, R. +3 more
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PLoS Computational Biology, 2020 Understanding the gating mechanism of ion channel proteins is key to understanding the regulation of cell signaling through these channels. Channel opening and closing are regulated by diverse environmental factors that include temperature, electrical ...
Juhwan Lee +3 more
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Effects of ionic strength on gating and permeation of TREK-2 K2P channels.
PLoS ONE, 2021 In addition to the classical voltage-dependent behavior mediated by the voltage-sensing-domains (VSD) of ion channels, a growing number of voltage-dependent gating behaviors are being described in channels that lack canonical VSDs.
Linus J Conrad +2 more
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Hydrophobic Gating in Ion Channels
Journal of Molecular Biology, 2015 Biological ion channels are nanoscale transmembrane pores. When water and ions are enclosed within the narrow confines of a sub-nanometer hydrophobic pore, they exhibit behavior not evident from macroscopic descriptions. At this nanoscopic level, the unfavorable interaction between the lining of a hydrophobic pore and water may lead to stochastic ...
Aryal, P, Sansom, MS, Tucker, S
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Energetic contributions to channel gating of residues in the muscle nicotinic receptor β1 subunit. [PDF]
PLoS ONE, 2013 In the pentameric ligand-gated ion channel family, transmitter binds in the extracellular domain and conformational changes result in channel opening in the transmembrane domain.
Gustav Akk +5 more
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