Results 11 to 20 of about 43,122 (263)
Hysteretic Conductance in Ion Channel Gating [PDF]
EntropyHysteresis seems to play a critical role in the generation and modulation of electrical signal events in neurons, muscles, and other excitable tissues. In voltage-gated ion channels, hysteretic conductance manifests under cycling changes in transmembrane
Bartek Lisowski +3 more
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Similarity of the ion occupations of K+ and Tl+ in the selectivity filter of a K+ channel, as verified by single-channel currents [PDF]
ChannelsVoltage-dependent gating in the selectivity filter of potassium channels is modulated by the permeating ions binding within the filter. In the viral Kcv channel, filter gating occurs on the sub-millisecond time scale.
Lena Diederich +3 more
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Information Entropy Metrics to Address the Complexity of Cooperative Gating of Ion Channels [PDF]
EntropyIon channels in biological membranes can form spatially localized clusters that exhibit cooperative gating behavior. In this mode, the activity of one channel modulates the opening probability of its neighbors.
Agata Wawrzkiewicz-Jałowiecka +3 more
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A mechanism of CALHM1 ion channel gating. [PDF]
Am J Physiol Cell PhysiolMa Z, Paudel U, Wang M, Foskett JK.
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Unmasking coupling between channel gating and ion permeation in the muscle nicotinic receptor
eLife, 2021 Whether ion channel gating is independent of ion permeation has been an enduring, unresolved question. Here, applying single channel recording to the archetypal muscle nicotinic receptor, we unmask coupling between channel gating and ion permeation by ...
John R Strikwerda, Steven M Sine
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The gates of ion channels and enzymes [PDF]
Trends in Biochemical Sciences, 2010 Protein dynamics are essential for virtually all protein functions, certainly for gating mechanisms of ion channels and regulation of enzyme catalysis. Ion channels usually feature a gate in the channel pore that prevents ion permeation in the closed state.
unknown ( host institution ) +1 more
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Voltage-Gated Ion Channels [PDF]
IEEE Transactions on Nanobioscience, 2005 Voltage-dependent ion channels are membrane proteins that conduct ions at high rates regulated by the voltage across the membrane. They play a fundamental role in the generation and propagation of the nerve impulse and in cell homeostasis. The voltage sensor is a region of the protein bearing charged amino acids that relocate upon changes in the ...
Sands, Z, Grottesi, A, Sansom, MS
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Nature Communications, 2022 Visualizing conformational changes during ion channel gating is crucial to understand their regulation. Here, Gao et al. capture multiple gating intermediates in a CNG channel as well as subtle, lateral voltage sensor movements necessary for channel ...
Xiaolong Gao +6 more
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Central cavity dehydration as a gating mechanism of potassium channels
Nature Communications, 2023 The hydrophobic gating model, in which ion permeation is inhibited by the hydrophobicity, rather than a physical occlusion of the nanopore, functions in various ion channels including potassium channels.
Ruo-Xu Gu, Bert L. de Groot
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Artificial modulation of the gating behavior of a K+ channel in a KvAP-DNA chimera. [PDF]
PLoS ONE, 2011 We present experiments where the gating behavior of a voltage-gated ion channel is modulated by artificial ligand binding. We construct a channel-DNA chimera with the KvAP potassium channel reconstituted in an artificial membrane.
Andrew Wang, Giovanni Zocchi
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