Results 31 to 40 of about 43,122 (263)
eLife, 2021 Ligand-gated ion channels conduct currents in response to chemical stimuli, mediating electrochemical signaling in neurons and other excitable cells.
Cathrine Bergh +3 more
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Gating Transition of Pentameric Ligand-Gated Ion Channels [PDF]
Biophysical Journal, 2009 Pentameric ligand-gated ion channels are an important family of membrane proteins and play key roles in physiological processes, including signal transduction at chemical synapses. Here, we study the conformational changes associated with the opening and closing of the channel pore.
Zhu, F. +1 more
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Ligand recognition and gating mechanism through three ligand-binding sites of human TRPM2 channel
eLife, 2019 TRPM2 is critically involved in diverse physiological processes including core temperature sensing, apoptosis, and immune response. TRPM2’s activation by Ca2+ and ADP ribose (ADPR), an NAD+-metabolite produced under oxidative stress and neurodegenerative
Yihe Huang, Becca Roth, Wei Lü, Juan Du
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Transcending Markov: non-Markovian rate processes of thermosensitive TRP ion channels
Royal Society Open Science, 2023 The Markov state model (MSM) is a popular theoretical tool for describing the hierarchy of time scales involved in the function of many proteins especially ion channel gating. An MSM is a particular case of the general non-Markovian model, where the rate
Yuval Ben-Abu +2 more
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PLoS Computational Biology, 2010 Neuronal activity is mediated through changes in the probability of stochastic transitions between open and closed states of ion channels. While differences in morphology define neuronal cell types and may underlie neurological disorders, very little is ...
Robert C Cannon +2 more
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An Unorthodox Mechanism Underlying Voltage Sensitivity of TRPV1 Ion Channel
Advanced Science, 2020 While the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1) channel is a polymodal nociceptor for heat, capsaicin, and protons, the channel's responses to each of these stimuli are profoundly regulated by membrane potential, damping or ...
Fan Yang +5 more
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Piezo’s membrane footprint and its contribution to mechanosensitivity
eLife, 2018 Piezo1 is an ion channel that gates open when mechanical force is applied to a cell membrane, thus allowing cells to detect and respond to mechanical stimulation.
Christoph A Haselwandter +1 more
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Role of the Ion Channel Extracellular Collar in AMPA Receptor Gating
Scientific Reports, 2017 AMPA subtype ionotropic glutamate receptors mediate fast excitatory neurotransmission and are implicated in numerous neurological diseases. Ionic currents through AMPA receptor channels can be allosterically regulated via different sites on the receptor ...
Maria V. Yelshanskaya +3 more
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Optical control of PIEZO1 channels
Nature Communications, 2023 PIEZO proteins are large, mechanically-activated trimeric ion channels. Here the authors report a light-gated mouse PIEZO1 channel, mOP1, whereby an azobenzene-based photoswitch covalently localised at the extracellular apex of a transmembrane helix ...
Francisco Andrés Peralta +8 more
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The ligand gated ion channel database [PDF]
Nucleic Acids Research, 1999 The ligand gated ion channels (LGICs) are ionotropic receptors to neurotransmitters. Their physiological effect is carried out by the opening of an ionic channel upon binding of a particular neurotransmitter. These LGICs constitute superfamilies of receptors formed by homologous subunits.
Nicolas Le Novère, Jean-Pierre Changeux
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