Results 11 to 20 of about 44,662 (217)
Energetic contributions to channel gating of residues in the muscle nicotinic receptor β1 subunit. [PDF]
PLoS ONE, 2013 In the pentameric ligand-gated ion channel family, transmitter binds in the extracellular domain and conformational changes result in channel opening in the transmembrane domain.
Gustav Akk +5 more
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eLife, 2021 Ligand-gated ion channels conduct currents in response to chemical stimuli, mediating electrochemical signaling in neurons and other excitable cells.
Cathrine Bergh +3 more
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Ligand recognition and gating mechanism through three ligand-binding sites of human TRPM2 channel
eLife, 2019 TRPM2 is critically involved in diverse physiological processes including core temperature sensing, apoptosis, and immune response. TRPM2’s activation by Ca2+ and ADP ribose (ADPR), an NAD+-metabolite produced under oxidative stress and neurodegenerative
Yihe Huang, Becca Roth, Wei Lü, Juan Du
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Transcending Markov: non-Markovian rate processes of thermosensitive TRP ion channels
Royal Society Open Science, 2023 The Markov state model (MSM) is a popular theoretical tool for describing the hierarchy of time scales involved in the function of many proteins especially ion channel gating. An MSM is a particular case of the general non-Markovian model, where the rate
Yuval Ben-Abu +2 more
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PLoS Computational Biology, 2010 Neuronal activity is mediated through changes in the probability of stochastic transitions between open and closed states of ion channels. While differences in morphology define neuronal cell types and may underlie neurological disorders, very little is ...
Robert C Cannon +2 more
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Piezo’s membrane footprint and its contribution to mechanosensitivity
eLife, 2018 Piezo1 is an ion channel that gates open when mechanical force is applied to a cell membrane, thus allowing cells to detect and respond to mechanical stimulation.
Christoph A Haselwandter +1 more
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An Unorthodox Mechanism Underlying Voltage Sensitivity of TRPV1 Ion Channel
Advanced Science, 2020 While the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1) channel is a polymodal nociceptor for heat, capsaicin, and protons, the channel's responses to each of these stimuli are profoundly regulated by membrane potential, damping or ...
Fan Yang +5 more
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Role of the Ion Channel Extracellular Collar in AMPA Receptor Gating
Scientific Reports, 2017 AMPA subtype ionotropic glutamate receptors mediate fast excitatory neurotransmission and are implicated in numerous neurological diseases. Ionic currents through AMPA receptor channels can be allosterically regulated via different sites on the receptor ...
Maria V. Yelshanskaya +3 more
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Site-directed spin labeling reveals pentameric ligand-gated ion channel gating motions. [PDF]
PLoS Biology, 2013 Pentameric ligand-gated ion channels (pLGICs) are neurotransmitter-activated receptors that mediate fast synaptic transmission. In pLGICs, binding of agonist to the extracellular domain triggers a structural rearrangement that leads to the opening of an ...
Cosma D Dellisanti +9 more
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A biomimetic chiral-driven ionic gate constructed by pillar[6]arene-based host–guest systems
Nature Communications, 2018 Uptake and release of glucose is regulated by glucose-sensitive ion channels, but complexity of the system impedes investigation of the gating behavior under physiological conditions.
Yue Sun +9 more
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