Results 111 to 120 of about 4,654,285 (364)
Advanced Biology, EarlyView.Infrared (IR) light evokes distinct calcium and water transport responses in astrocytes, depending on stimulation duration and protocol. This study uses widefield imaging and pharmacology to reveal differential engagement of astroglial signaling pathways.
Wilson R. Adams +7 more
wiley +1 more source
Cell Death and DiseaseTRPV6 calcium channel is a prospective target in prostate cancer (PCa) since it is not expressed in healthy prostate while its expression increases during cancer progression.
Aurélien Haustrate +16 more
doaj +1 more source
Aptamer Efficacies for In Vitro and In Vivo Modulation of αC-Conotoxin PrXA Pharmacology
Molecules, 2019 The medical staff is often powerless to treat patients affected by drug abuse or misuse and poisoning. In the case of envenomation, the treatment of choice remains horse sera administration that poses a wealth of other medical conditions and threats ...
Germain Sotoing Taiwe +12 more
doaj +1 more source
Interaction of ions and water in gramicidin A channels: streaming potentials across lipid bilayer membranes. [PDF]
, 1978 Paul A. Rosenberg, Alexei V. Finkelstein
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Channels, 2015 Ion channels are critical for all aspects of cardiac function, including rhythmicity and contractility. Consequently, ion channels are key targets for therapeutics aimed at cardiac pathophysiologies such as atrial fibrillation or angina. At the same time,
B. Priest, J. McDermott
semanticscholar +1 more source
Advanced Biology, EarlyView.The unrolling of the peltate leaves in Syngonium podophyllum is analyzed and quantified (left‐hand side to center). These measurements serve to verify a mathematical model for leaf unrolling based on the model used in Schmidt (2007). An additional formula for obtaining a layer mismatch from a prescribed radius is derived.
Michelle Modert +4 more
wiley +1 more source
Interaction of Tetraethylammonium Ion Derivatives with the Potassium Channels of Giant Axons [PDF]
, 1971 Clay M. Armstrong
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Advanced Biology, EarlyView.Amide local anesthetics (LA) affect tumor burden in various preclinical studies, possibly via their anti‐inflammatory properties. However, a translation into clinical evidence is still lacking. The current study demonstrates that LA ‐ even at clinically relevant concentrations – exert a strong anti‐tumoral effect in a complex ex vivo model patient ...
Juliane Krömer +8 more
wiley +1 more source
High throughput screening technologies for ion channels
Acta Pharmacologica Sinica, 2015 Ion channels are involved in a variety of fundamental physiological processes, and their malfunction causes numerous human diseases. Therefore, ion channels represent a class of attractive drug targets and a class of important off-targets for in vitro ...
Hai-bo Yu +3 more
semanticscholar +1 more source
A Spatially Resolved View on the Aging Substantia nigra: An Exploratory Proteomic Study
Advanced Biology, EarlyView.Although aging is the most important risk factor for several neurodegenerative diseases, the molecular effects of physiological aging are still understudied. By applying spatially‐resolved proteomic analyses of the human substantia nigra pars compacta, alterations in vesicular trafficking and mitochondrial proteins are observed, as well as reduced ...
Britta Eggers +10 more
wiley +1 more source