Results 101 to 110 of about 2,126,685 (298)

Mepyramine targets mutant Nav1.7 channels to relieve pain and erythema in primary erythromelalgia patients

Frontiers in Medicine
Gain-of-function mutations in SCN9A, which encodes the Nav1.7 voltage-gated sodium channel, are known to cause primary erythromelalgia (PEM). This condition is characterized by recurrent episodes of erythema, burning pain, and warmth in the extremities ...
Myriam Ducrocq, Myriam Ducrocq, Virginie Penalba, Virginie Penalba, Laura Castillo, Laura Castillo, Christine Bodemer, Céline Greco, Patrick Delmas, Patrick Delmas   +9 more
doaj   +1 more source

Accessory and Central α-helices of Complexin Selectively Activate Ca2+ Triggering of Synaptic Exocytosis

Frontiers in Molecular Neuroscience, 2018
Complexins, binding to assembling soluble NSF-attachment protein receptor (SNARE) complexes, activate Ca2+ triggered exocytosis and clamp spontaneous release in the presynaptic terminal. Functions of complexin are structural dependent and mechanistically
Yi Yu, Su Chen, Xiaoqiang Mo, Jihong Gong, Chenhong Li, Xiaofei Yang   +5 more
doaj   +1 more source

Nanoscale-targeted patch-clamp recordings of functional presynaptic ion channels [PDF]

, 2013
Important modulatory roles have been attributed to presynaptic NMDA receptors (NMDARs) located on cerebellar interneuron terminals. Evidence supporting a presynaptic location includes an increase in the frequency of mini events following the application ...
Caldwell, M, Robertson, AD, Moss, GWJ, Benton, DCH, Smart, TG   +4 more
core  

Field Report from Collaborative Research Center 1625: Heterogeneous Research Data Management Using Ontology Representations

Advanced Engineering Materials, EarlyView.
A unified research data management framework for heterogeneous materials data is presented. The system integrates multimodal datasets using ontologies and knowledge graphs, enabling interoperability and FAIR (findable, accessible, interoperable, reusable) data principles. By linking data across scales and workflows, it supports reproducible, Artifitial
Doaa Mohamed, Samuel García Vázquez, Behnam Mardani, Victor Dudarev, Alfred Ludwig, Maribel Acosta, Markus Stricker   +6 more
wiley   +1 more source

[Mitochondrial ion channels].

Postepy biochemii, 2006
Ion channels are proteins, which facilitate the ions flow throught biological membranes. In recent years the structure as well as the function of the plasma membrane ion channels have been well investigated. The knowledge of intracellular ion channels however is still poor.
Skalska, Jolanta, Debska-Vielhaber, Grazyna, Głab, Marta, Kulawiak, Bogusz, Malińska, Dominika, Koszela-Piotrowska, Izabela, Piotr Bednarczyk, Krzysztof Dołowy, Adam Szewczyk   +8 more
openaire   +1 more source

Epilepsy and ion channels

Rinsho Shinkeigaku, 2017
Many mutations of genes for ion channels result in some epilepsies. Their electrophysiological studies reveal pathophysiological mechanisms underlining epilepsy and also mechanism of action of several antiepileptic drugs. In this review, We briefly summarize pathophysiology of epilepsy and the mechanisms of antiepileptic drugs.
Yoshihiro, Sugiura, Yoshikazu, Ugawa
openaire   +3 more sources

Towards Defect Phase Diagrams: From Research Data Management to Automated Workflows

Advanced Engineering Materials, EarlyView.
A research data management infrastructure is presented for the systematic integration of heterogeneous experimental and simulation data required for defect phase diagrams. The approach combines openBIS with a companion application for large‐object storage, automated metadata extraction, provenance tracking and federated data access, thereby supporting ...
Khalil Rejiba, Sang‐Hyeok Lee, Christina Gasper, Martina Freund, Sandra Korte‐Kerzel, Ulrich Kerzel   +5 more
wiley   +1 more source

Trpv6 channel targeting using monoclonal antibody induces prostate cancer cell apoptosis and tumor regression

Cell Death and Disease
TRPV6 calcium channel is a prospective target in prostate cancer (PCa) since it is not expressed in healthy prostate while its expression increases during cancer progression.
Aurélien Haustrate, Clément Cordier, George Shapovalov, Adriana Mihalache, Emilie Desruelles, Benjamin Soret, Nadège Charlène Essonghé, Corentin Spriet, Maya Yassine, Alexandre Barras, Johanna Marines, Lindsay B. Alcaraz, Sabine Szunerits, Gautier Robin, Pierre Gosset, Natalia Prevarskaya, V’yacheslav Lehen’kyi   +16 more
doaj   +1 more source

Efficient functional neutralization of lethal peptide toxins in vivo by oligonucleotides

Scientific Reports, 2017
Medical means to save the life of human patients affected by drug abuse, envenomation or critical poisoning are currently limited. While the compounds at risks are most often well identified, particularly for bioterrorism, chemical intervention to ...
Tarek Mohamed Abd El-Aziz, Corinne Ravelet, Jordi Molgo, Emmanuelle Fiore, Simon Pale, Muriel Amar, Sawsan Al-Khoury, Jérôme Dejeu, Mahmoud Fadl, Michel Ronjat, Germain Sotoing Taiwe, Denis Servent, Eric Peyrin, Michel De Waard   +13 more
doaj   +1 more source

Time‐Dependent Oxidation and Scale Evolution of a Wrought Co/Ni‐Based Superalloy

Advanced Engineering Materials, EarlyView.
This study shows how a new wrought Co/Ni‐based superalloy resists oxidation at 800 ∘$^\circ$C. The oxide scale changes from rough, fast‐growing spinel to a dense, protective chromia–alumina layer. Atom probe analysis reveals tiny refractory‐rich bubbles at the interface that mark the transition to long‐term, diffusion‐controlled protection ...
Cameron Crabb, Zachary T. Kloenne, Samuel R. Rogers, Chi Hang Dominik Kwok, Mark C. Hardy, Michele S. Conroy, David Dye   +6 more
wiley   +1 more source