Results 81 to 90 of about 810,377 (300)

Single-channel recordings from cultured human retinal pigment epithelial cells. [PDF]

, 1988
We have applied patch-clamp techniques to on-cell and excised-membrane patches from human retinal pigment epithelial cells in tissue culture. Single-channel currents from at least four ion channel types were observed: three or more potassium-selective ...
Fain, GL, Fox, JA, Pfeffer, BA
core  

Ion channel expression in human melanoma samples. in silico identification and experimental validation of molecular targets [PDF]

, 2019
Expression of 328 ion channel genes was investigated, by in silico analysis, in 170 human melanoma samples and controls. Ninety-one members of this gene-family (i.e., about 28%) show a significant (p 0.90 and p 90% in most cases).
D’Arcangelo, Daniela, Facchiano, Antonio, Facchiano, Francesco, Giampietri, Claudia, Marchetti, Paolo, Scatozza, Francesca   +5 more
core   +1 more source

Epilepsy and ion channels

Rinsho Shinkeigaku, 2017
Many mutations of genes for ion channels result in some epilepsies. Their electrophysiological studies reveal pathophysiological mechanisms underlining epilepsy and also mechanism of action of several antiepileptic drugs. In this review, We briefly summarize pathophysiology of epilepsy and the mechanisms of antiepileptic drugs.
Sugiura, Yoshihiro, Ugawa, Yoshikazu
openaire   +3 more sources

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Modeled channel distributions explain extracellular recordings from cultured neurons sealed to microelectrodes [PDF]

, 2002
Amplitudes and shapes of extracellular recordings from single neurons cultured on a substrate embedded microelectrode depend not only on the volume conducting properties of the neuron-electrode interface, but might also depend on the distribution of ...
Buitenweg, Jan Reinoud, Marani, Enrico, Rutten, Wim L.C.   +2 more
core   +3 more sources

ION CHANNELS OF NOCICEPTION [PDF]

Annual Review of Physiology, 1999
▪ Abstract  Nociceptors are the first cells in the series of neurons that lead to the sensation of pain. The essential functions of nociceptors—transducing noxious stimuli into depolarizations that trigger action potentials, conducting the action potentials from the peripheral sensory site to the synapse in the central nervous system, and converting ...
E W, McCleskey, M S, Gold
openaire   +2 more sources

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Spiropyran modified micro-fluidic chip channels as photonically controlled self-indicating system for metal ion accumulation and release [PDF]

, 2009
In this paper, we show how through integrating the beneficial characteristics of micro-fluidic devices and spiropyrans dyes, a simple and very innovative chip configured as an on-line photonically controlled self-indicating system for metal ion ...
Attia, Baillet, Baillet, Baltussen, Basabe-Desmonts, Bowden, Brett Paull, Byrne, Byrne, Chibisov, Collins, Dalavoy, Demadrille, Dermot Diamond, Diamond, Dong, Duffy, Evans, Fernando Benito-Lopez, Garcia, Gorner, Hillborg, Inouye, Joensson, Johnson, Kim, Matsushima, Mirek Macka, Ng, Olah, Owen, Radu, Ren, Rosario, Sakata, Scarmagnani, Shao, Shao, Silvia Scarmagnani, Song, Stitzel, Suzuki, Theodoridis, Tian, Toepke, West, Wu, Yager, Yang, Young, Zarah Walsh, Zhang   +51 more
core   +1 more source

The ion channels of endomembranes

Physiological Reviews
The endomembrane system consists of organellar membranes in the biosynthetic pathway [endoplasmic reticulum (ER), Golgi apparatus, and secretory vesicles] as well as those in the degradative pathway (early endosomes, macropinosomes, phagosomes, autophagosomes, late endosomes, and lysosomes).
Meiqin Hu, Xinghua Feng, Qiang Liu, Siyu Liu, Fangqian Huang, Haoxing Xu   +5 more
openaire   +2 more sources