Results 1 to 10 of about 5,395 (299)

Pharmacological Actions of Potassium Channel Openers on Voltage-Gated Potassium Channels [PDF]

Pharmaceuticals
Background/Objectives: Potassium (K+) channels are essential transmembrane proteins that regulate ion flow, playing a critical role in regulating action potentials and neuronal transmission.
Michael T. McCoy, Bruce Ladenheim, Jean Lud Cadet, Atul P. Daiwile   +3 more
doaj   +3 more sources

Small and Intermediate Calcium-Activated Potassium Channel Openers Improve Rat Endothelial and Erectile Function [PDF]

Frontiers in Pharmacology, 2017
Modulation of endothelial calcium-activated potassium (KCa) channels has been proposed as an approach to restore endothelial function. The present study investigated whether novel openers of KCa channels with small (KCa2.x) and intermediate (KCa3.1 ...
Simon G. Comerma-Steffensen, Simon G. Comerma-Steffensen, Ingrid Carvacho, Ingrid Carvacho, Elise R. Hedegaard, Ulf Simonsen   +5 more
doaj   +2 more sources

Big conductance calcium-activated potassium channel openers control spasticity without sedation. [PDF]

Br J Pharmacol, 2017
BACKGROUND AND PURPOSE: Our initial aim was to generate cannabinoid agents that control spasticity, occurring as a consequence of multiple sclerosis (MS), whilst avoiding the sedative side effects associated with cannabis.
Baker D, Pryce G, Visintin C, Sisay S, Bondarenko AI, Vanessa Ho WS, Jackson SJ, Williams TE, Al-Izki S, Sevastou I, Okuyama M, Graier WF, Stevenson LA, Tanner C, Ross R, Pertwee RG, Henstridge CM, Irving AJ, Schulman J, Powell K, Baker MD, Giovannoni G, Selwood DL.   +22 more
europepmc   +7 more sources

Migraine is a dysfunction of neuronal potassium ion channels [PDF]

Frontiers in Neurology
Migraine is a primary headache disorder characterized by unilateral pain usually with aura, that affects approximately one in six individuals in India.
Girishwaran M., S. Sajitha Lulu
doaj   +2 more sources

Activation of KATP channels in pain modulation: a systematic review of preclinical studies [PDF]

Frontiers in Physiology
ObjectiveTo systematically review the involvement of KATP channel activation in pain modulation in preclinical studies.BackgroundKATP channels are expressed at several levels in the spinal and trigeminal pain pathways, where they seem to modulate ...
Signe Schønning Beich, Lili Kokoti, Mohammad Al-Mahdi Al-Karagholi, Mohammad Al-Mahdi Al-Karagholi   +3 more
doaj   +2 more sources

Myocardial protection by adenosine triphosphate−sensitive potassium channel opener diazoxide involves sulfonylurea receptor 2 subunitCentral MessagePerspective [PDF]

JTCVS Open
Objective: Pharmacologic openers of adenosine triphosphate-sensitive potassium (KATP) channels mimic ischemic preconditioning and are cardioprotective.
Jie Wang, MD, AlleaBelle Bradshaw, MD, Robert Tryon, PhD, Rachel Pan, Sari D. Holmes, PhD, Colin Nichols, PhD, Jennifer S. Lawton, MD   +6 more
doaj   +2 more sources

Understanding mitochondrial potassium channels: 33 years after discovery [PDF]

Acta Biochimica Polonica
Mitochondrial investigations have extended beyond their traditional functions, covering areas such as ATP synthesis and metabolism. Mitochondria are now implicated in new functional areas such as cytoprotection, cellular senescence, tumor function and ...
Adam Szewczyk
doaj   +2 more sources

From genes to clinical management: A comprehensive review of long QT syndrome pathogenesis and treatment [PDF]

Heart Rhythm O2
Background: Long QT syndrome (LQTS) is a rare cardiac disorder characterized by prolonged ventricular repolarization and increased risk of ventricular arrhythmias.
Wenjing Zhu, BS, Xueyan Bian, BS, Jianli Lv, PhD   +2 more
doaj   +2 more sources

Current Challenges of Mitochondrial Potassium Channel Research

Frontiers in Physiology, 2022
In this paper, the current challenges of mitochondrial potassium channels research were critically reviewed. Even though recent progress in understanding K+ traffic in mitochondria has been substantial, some basic issues of this process remain unresolved.
Bogusz Kulawiak, Adam Szewczyk
doaj   +1 more source

Potassium channel openers and prostacyclin play a crucial role in mediating the vasorelaxant activity of Gynura procumbens. [PDF]

BMC Complement Altern Med, 2013
Ng HK, Poh TF, Lam SK, Hoe SZ.
europepmc   +2 more sources