Pharmacological Actions of Potassium Channel Openers on Voltage-Gated Potassium Channels [PDF]
PharmaceuticalsBackground/Objectives: Potassium (K+) channels are essential transmembrane proteins that regulate ion flow, playing a critical role in regulating action potentials and neuronal transmission.
Michael T. McCoy +3 more
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Small and Intermediate Calcium-Activated Potassium Channel Openers Improve Rat Endothelial and Erectile Function [PDF]
Frontiers in Pharmacology, 2017 Modulation of endothelial calcium-activated potassium (KCa) channels has been proposed as an approach to restore endothelial function. The present study investigated whether novel openers of KCa channels with small (KCa2.x) and intermediate (KCa3.1 ...
Simon G. Comerma-Steffensen +5 more
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Migraine is a dysfunction of neuronal potassium ion channels [PDF]
Frontiers in NeurologyMigraine is a primary headache disorder characterized by unilateral pain usually with aura, that affects approximately one in six individuals in India.
Girishwaran M., S. Sajitha Lulu
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Bulletin of Faculty of Pharmacy Cairo University, 2017 Objectives: This study was done to estimate the potential neuroprotective role of potassium channel openers in cerebral ischemia–reperfusion (IR) injury in streptozotocin (STZ) induced type-I diabetic rats (T1DR).
Anand B. Pithadia +2 more
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Myocardial protection by adenosine triphosphate−sensitive potassium channel opener diazoxide involves sulfonylurea receptor 2 subunitCentral MessagePerspective [PDF]
JTCVS OpenObjective: Pharmacologic openers of adenosine triphosphate-sensitive potassium (KATP) channels mimic ischemic preconditioning and are cardioprotective.
Jie Wang, MD +6 more
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Potassium channel-targeted therapy in reducing vascular complications in diabetes mellitus: novel insights [PDF]
Frontiers in PharmacologyPotassium (K+) channels are the most diverse group of ion channels and are required for many physiological functions such as cell excitability and insulin secretion.
Jovana Rajkovic +6 more
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Activation of KATP channels in pain modulation: a systematic review of preclinical studies [PDF]
Frontiers in PhysiologyObjectiveTo systematically review the involvement of KATP channel activation in pain modulation in preclinical studies.BackgroundKATP channels are expressed at several levels in the spinal and trigeminal pain pathways, where they seem to modulate ...
Signe Schønning Beich +3 more
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ATP sensitive potassium channel openers: A new class of ocular hypotensive agents [PDF]
Experimental Eye Research, 2017 Uttio Roy Chowdhury +2 more
exaly +2 more sources
Current Challenges of Mitochondrial Potassium Channel Research
Frontiers in Physiology, 2022 In this paper, the current challenges of mitochondrial potassium channels research were critically reviewed. Even though recent progress in understanding K+ traffic in mitochondria has been substantial, some basic issues of this process remain unresolved.
Bogusz Kulawiak, Adam Szewczyk
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Alternative Targets for Modulators of Mitochondrial Potassium Channels
Molecules, 2022 Mitochondrial potassium channels control potassium influx into the mitochondrial matrix and thus regulate mitochondrial membrane potential, volume, respiration, and synthesis of reactive oxygen species (ROS).
Antoni Wrzosek +4 more
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