Alpha and omega in potassium‐channel opening [PDF]
Acta Physiologica, 2018 n ...
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Levosimendan-Induced Venodilation is Mediated by Opening of Potassium Channels [PDF]
ESC Heart Failure, 2021 Abstract Unique vascular responses adhere to the cardiovascular efficacy of the inodilator levosimendan. In particular, selective venodilation appears to explain its clinical benefit during pulmonary hypertension complicated by heart failure with preserved ejection fraction.
Daniel Burkhoff +3 more
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Open channel block of Kv1.4 potassium channels by aripiprazole
The Korean Journal of Physiology & Pharmacology, 2020 Aripiprazole is a quinolinone derivative approved as an atypical antipsychotic drug for the treatment of schizophrenia and bipolar disorder. It acts as with partial agonist activities at the dopamine D2 receptors. Although it is known to be relatively safe for patients with cardiac ailments, less is known about the effect of aripiprazole on voltage ...
Park, Jeaneun +4 more
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Effect of Potassium Channel Modulators on Morphine Withdrawal in Mice
Substance Abuse: Research and Treatment, 2010 The present study was conducted to investigate the effect of potassium channel openers and blockers on morphine withdrawal syndrome. Mice were rendered dependent on morphine by subcutaneous injection of morphine; four hours later, withdrawal was induced ...
Vikas Seth +4 more
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ATP-sensitive potassium (KATP) channel openers diazoxide and nicorandil lower intraocular pressure by activating the Erk1/2 signaling pathway. [PDF]
PLoS ONE, 2017 Elevated intraocular pressure is the most prevalent and only treatable risk factor for glaucoma, a degenerative disease of the optic nerve. While treatment options to slow disease progression are available, all current therapeutic and surgical treatments
Uttio Roy Chowdhury +3 more
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The periprocedural myocardial damage prevention during elective percutaneous coronary intervention as a result of pharmacological preconditioning with an oral form of nicorandil in patients with stable coronary artery disease. Pilot study [PDF]
Терапевтический архив, 2018 The purpose of the study is to prove the effectiveness of pharmacological preconditioning caused by nicorandil in patients with stable coronary heart disease (CHD) during the elective percutaneous coronary intervention (PCI). Materials and methods.
R V Gostishchev +4 more
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KCNQ channel openers reverse depressive symptoms via an active resilience mechanism
Nature Communications, 2016 Potassium channels in the ventral tegmental area are known to regulate resilience against stress-induced depression. Here, the authors show over expression of KCNQ3 channels in VTA dopaminergic neurons or treatment with KCNQ channel openers normalizes ...
Allyson K. Friedman +14 more
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Activation of Peripheral KCNQ Channels Attenuates Inflammatory Pain
Molecular Pain, 2014 Background: Refractory chronic pain dramatically reduces the quality of life of patients. Existing drugs cannot fully achieve effective chronic pain control because of their lower efficacy and/or accompanying side effects.
Hiroki Hayashi +3 more
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Pharmaceuticals, 2023 Migraine is a highly disabling pain disorder with huge socioeconomic and personal costs. It is genetically heterogenous leading to variability in response to current treatments and frequent lack of response. Thus, new treatment strategies are needed.
Tino Dyhring +3 more
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Initial steps in the opening of a Shaker potassium channel [PDF]
Proceedings of the National Academy of Sciences, 2012 The structural model of a K V (K + -selective, voltage-gated) channel in the open state is known (Protein Data Bank ID code 2R9R). Each subunit of the channel has four negatively charged residues distributed in the transmembrane segments S1, S2, and S3 that bind to and facilitate the movement
Toshinori, Hoshi, Clay M, Armstrong
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