Results 21 to 30 of about 3,196 (289)

Effects of potassium channel modulators on the responses of mammalian slowly adapting mechanoreceptors

IBRO Neuroscience Reports, 2022
Introduction: slowly adapting mechanoreceptors in the skin provide vital tactile information to animals. The ionic channels that underlie their functioning is the subject of intense research.
Peter M.B. Cahusac, Solomon S. Senok
doaj   +1 more source

Inhibition of Contractility of Isolated Caprine Detrusor by the Calcium Channel Blocker Cilnidipine and Reversal by Calcium Channel Openers

Current Therapeutic Research, 2023
: Background: Cilnidipine is a fourth-generation calcium channel blocker that is clinically used to treat hypertension. It is a dihydropyridine that blocks L- and N-type calcium channels.
Steffi A. Maria, MD, Aniket Kumar, PhD, Premila M. Wilfred, MD, Margaret Shanthi, MD, Jacob Peedicayil, MD   +4 more
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Multidimensional Regulation of Cardiac Mitochondrial Potassium Channels

Cells, 2021
Mitochondria play a fundamental role in the energetics of cardiac cells. Moreover, mitochondria are involved in cardiac ischemia/reperfusion injury by opening the mitochondrial permeability transition pore which is the major cause of cell death.
Bogusz Kulawiak, Piotr Bednarczyk, Adam Szewczyk   +2 more
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The Mitochondrial K Channel as a Receptor for Potassium Channel Openers [PDF]

Journal of Biological Chemistry, 1996
The biochemical properties of the mitochondrial KATP channel are very similar to those of plasma membrane KATP channels, including inhibition by low concentrations of ATP and glyburide (Paucek, P., Mironova, G., Mahdi, F., Beavis, A. D., Woldegiorgis, G., and Garlid, K. D. (1992) J. Biol. Chem. 267, 26062-26069).
K D, Garlid, P, Paucek, V, Yarov-Yarovoy, X, Sun, P A, Schindler   +4 more
openaire   +2 more sources

Potassium channels as drugs targets in therapy of cardiovascular diseases: 25 years later [PDF]

Sanamed, 2013
Potassium channels are the most variable ion channel group. They participate in numerous cardiovascular functions, for example regulation of vascular tone, maintenance of resting cardiac membrane potential and excitability of cardiac conduction tissue ...
Protić Dragana, Todorović Zoran, Gojković-Bukarica Ljiljana   +2 more
doaj   +2 more sources

A K_ATP channel opener inhibited myocardial reperfusion action potential shortening and arrhythmias [PDF]

, 2001
Low concentrations of certain K_ATP channel openers have been reported to exert a moderate inhibitory effect on arrhythmias during post-ischaemic early myocardial reperfusion, but the accompanying effects on the time course of ...
Northover, B.J., Ian MacKenzie, Basil J Northover, Antony J Workman, MacKenzie, I., Workman, A.J.   +5 more
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Alpha and omega in potassium‐channel opening [PDF]

Acta Physiologica, 2018
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Mitochondrial potassium channel opener diazoxide preserves neuronal-vascular function after cerebral ischemia in newborn pigs [PDF]

, 1999
Background and Purpose-N-Methyl-D-aspartate (NMDA) elicits neuronally mediated cerebral arteriolar vasodilation that is reduced by ischemia/reperfusion (I/R).
David W. Busija, Perciaccante, J. V., Ferenc Domoki, James V. Perciaccante, Domoki, Ferenc, Bari, Ferenc, Ferenc Bari, Roland Veltkamp, Veltkamp, R.   +8 more
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High conductance anion channel in Schwann cell vesicles from rat spinal roots [PDF]

, 1992
Potassium uptake, possibly together with chloride, is one of the presumed functions of Schwann cells in the peripheral nervous system. However, the presence of chloride channels has not been demonstrated in adult Schwann cells.
Quasthoff, Stefan, Stefan Quasthoff, Peter Grafe, Strupp, Michael, Grafe, Peter, Michael Strupp   +5 more
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Immunolocalization of KATP channel subunits in mouse and rat cardiac myocytes and the coronary vasculature. [PDF]

, 2005
BACKGROUND: Electrophysiological data suggest that cardiac KATP channels consist of Kir6.2 and SUR2A subunits, but the distribution of these (and other KATP channel subunits) is poorly defined.
Artman, M, Alison Morrissey, Tomoe Y Nakamura, Yoshida, H, Parachuru, L, Nakamura, TY, Coetzee, WA, Lavanya Parachuru, Hidetada Yoshida, Andrew Tinker, Lanning, J, Gwendolyn Lopez, Morrissey, A, Michael Artman, William A Coetzee, Lopez, G, Tong, X, Dhar Chowdhury, P, XiaoYong Tong, Han, S, Jonathan P Giblin, Sandra Han, Giblin, JP, Erika Rosner, Jennifer Lanning, Piyali Dhar Chowdhury, Tinker, A, Rosner, E   +27 more
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