Pharmacodynamics of potassium channel openers in cultured neuronal networks [PDF]
, 2014 Article discussing pharmacodynamics of potassium channel openers in cultured neuronal ...
Gopal, Kamakshi V. +4 more
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A KATP channel opener inhibited myocardial reperfusion action potential shortening and arrhythmias [PDF]
, 2001 Low concentrations of certain K<sub>ATP</sub> channel openers have been reported to exert a moderate inhibitory effect on arrhythmias during post-ischaemic early myocardial reperfusion, but the accompanying effects on the time course of ...
Northover, B.J. +5 more
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ATP-sensitive potassium (KATP) channel openers diazoxide and nicorandil lower intraocular pressure by activating the Erk1/2 signaling pathway. [PDF]
PLoS ONE, 2017 Elevated intraocular pressure is the most prevalent and only treatable risk factor for glaucoma, a degenerative disease of the optic nerve. While treatment options to slow disease progression are available, all current therapeutic and surgical treatments
Uttio Roy Chowdhury +3 more
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The periprocedural myocardial damage prevention during elective percutaneous coronary intervention as a result of pharmacological preconditioning with an oral form of nicorandil in patients with stable coronary artery disease. Pilot study [PDF]
Терапевтический архив, 2018 The purpose of the study is to prove the effectiveness of pharmacological preconditioning caused by nicorandil in patients with stable coronary heart disease (CHD) during the elective percutaneous coronary intervention (PCI). Materials and methods.
R V Gostishchev +4 more
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KCNQ channel openers reverse depressive symptoms via an active resilience mechanism
Nature Communications, 2016 Potassium channels in the ventral tegmental area are known to regulate resilience against stress-induced depression. Here, the authors show over expression of KCNQ3 channels in VTA dopaminergic neurons or treatment with KCNQ channel openers normalizes ...
Allyson K. Friedman +14 more
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High conductance anion channel in Schwann cell vesicles from rat spinal roots [PDF]
, 1992 Potassium uptake, possibly together with chloride, is one of the presumed functions of Schwann cells in the peripheral nervous system. However, the presence of chloride channels has not been demonstrated in adult Schwann cells.
Quasthoff, Stefan +5 more
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Activation of Peripheral KCNQ Channels Attenuates Inflammatory Pain
Molecular Pain, 2014 Background: Refractory chronic pain dramatically reduces the quality of life of patients. Existing drugs cannot fully achieve effective chronic pain control because of their lower efficacy and/or accompanying side effects.
Hiroki Hayashi +3 more
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Pharmaceuticals, 2023 Migraine is a highly disabling pain disorder with huge socioeconomic and personal costs. It is genetically heterogenous leading to variability in response to current treatments and frequent lack of response. Thus, new treatment strategies are needed.
Tino Dyhring +3 more
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Synthesis and vasorelaxant activity of new 1,4-benzoxazine derivatives potassium channel openers.
, 2002 As part of a search for new potassium channel openers, the synthesis and vasorelaxant activity of new 1,4-benzoxazine derivatives derived from transformation of the benzopyran skeleton of cromakalim were described.
SEVERINO, BEATRICE +8 more
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Investigation of the pharmacophore of BK[ca] potassium channel openers. [PDF]
Large conductance voltage-activated calcium-sensitive potassium channels (BK[ca]) are fundamental in the control of cellular excitability which is critical in the regulation of many physiological processes. Agents that activate the channel (openers) have
Kirby, Robert William.
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