Potassium channels as drugs targets in therapy of cardiovascular diseases: 25 years later [PDF]
Sanamed, 2013 Potassium channels are the most variable ion channel group. They participate in numerous cardiovascular functions, for example regulation of vascular tone, maintenance of resting cardiac membrane potential and excitability of cardiac conduction tissue ...
Protić Dragana +2 more
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Mitochondrial potassium channel opener diazoxide preserves neuronal-vascular function after cerebral ischemia in newborn pigs [PDF]
, 1999 Background and Purpose-N-Methyl-D-aspartate (NMDA) elicits neuronally mediated cerebral arteriolar vasodilation that is reduced by ischemia/reperfusion (I/R).
David W. Busija +4 more
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Do KATP channels open as a prominent and early feature during ischaemia in the Langendorff-perfused rat heart? [PDF]
, 2000 The objective was to investigate whether myocardial adenosine triphosphate-sensitive K<sup>+</sup> (K<sub>ATP</sub>) channels open during the first 10 min of regional ischaemia in Langendorff-perfused rat hearts.
MacKenzie, I. +2 more
core +1 more source
KATP Channel Openers Have Opposite Effects on Mitochondrial Respiration Under Different Energetic Conditions [PDF]
, 2008 Mitochondrial (m) KATP channel opening has been implicated in triggering cardiac preconditioning. Its consequence on mitochondrial respiration, however, remains unclear. We investigated the effects of two different KATP channel openers and antagonists on
Camara, Amadou K.S. +5 more
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Cromakalim (BRL 34915) restores in vitro the membrane potential of depolarized human skeletal muscle fibres [PDF]
, 1989 The purpose of the present study was to analyze the effects of cromakalim (BRL 34915), a potent drug from a new class of drugs characterized as K+ channel openers, on the electrical activity of human skeletal muscle.
Grafe, Peter +2 more
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Open-State Models of a Potassium Channel [PDF]
Biophysical Journal, 2002 The structure of the bacterial potassium channel, KcsA, corresponds to the channel in a closed state. Two lines of evidence suggest that the channel must widen its intracellular mouth when in an open state: 1) internal block by a series of tetraalkylammonium ions and 2) spin labeling experiments.
Biggin, P, Sansom, MS
openaire +2 more sources
Effect of Potassium Channel Modulators on Morphine Withdrawal in Mice
Substance Abuse: Research and Treatment, 2010 The present study was conducted to investigate the effect of potassium channel openers and blockers on morphine withdrawal syndrome. Mice were rendered dependent on morphine by subcutaneous injection of morphine; four hours later, withdrawal was induced ...
Vikas Seth +4 more
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The periprocedural myocardial damage prevention during elective percutaneous coronary intervention as a result of pharmacological preconditioning with an oral form of nicorandil in patients with stable coronary artery disease. Pilot study [PDF]
Терапевтический архив, 2018 The purpose of the study is to prove the effectiveness of pharmacological preconditioning caused by nicorandil in patients with stable coronary heart disease (CHD) during the elective percutaneous coronary intervention (PCI). Materials and methods.
R V Gostishchev +4 more
doaj +1 more source
A KATP channel opener inhibited myocardial reperfusion action potential shortening and arrhythmias [PDF]
, 2001 Low concentrations of certain K<sub>ATP</sub> channel openers have been reported to exert a moderate inhibitory effect on arrhythmias during post-ischaemic early myocardial reperfusion, but the accompanying effects on the time course of ...
MacKenzie, I. +2 more
core +1 more source
ATP-sensitive potassium (KATP) channel openers diazoxide and nicorandil lower intraocular pressure by activating the Erk1/2 signaling pathway. [PDF]
PLoS ONE, 2017 Elevated intraocular pressure is the most prevalent and only treatable risk factor for glaucoma, a degenerative disease of the optic nerve. While treatment options to slow disease progression are available, all current therapeutic and surgical treatments
Uttio Roy Chowdhury +3 more
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