Results 41 to 50 of about 5,395 (299)

Pharmacological Profiling of K_ATP Channel Modulators: An Outlook for New Treatment Opportunities for Migraine

Pharmaceuticals, 2023
Migraine is a highly disabling pain disorder with huge socioeconomic and personal costs. It is genetically heterogenous leading to variability in response to current treatments and frequent lack of response. Thus, new treatment strategies are needed.
Tino Dyhring, Inger Jansen-Olesen, Palle Christophersen, Jes Olesen   +3 more
doaj   +1 more source

Activation of ATP-Sensitive Potassium Channels Antagonize Nociceptive Behavior and Hyperexcitability of DRG Neurons from Rats [PDF]

, 2011
Background: Nociceptive responses to noxious stimuli are initiated at peripheral nociceptor terminals. Ion channels play a vital role in pain signal initiation and conduction.
Xiaona Du, Chao Wang, Hailin Zhang
core   +1 more source

Diazoxide maintains human myocyte volume homeostasis during stress [PDF]

, 2012
BACKGROUND: Exposure to hypothermic hyperkalemic cardioplegia, hyposmotic stress, or metabolic inhibition results in significant animal myocyte swelling (6% to10%) and subsequent reduced contractility (10% to 20%).
Al-Dadah, Ashraf S, Damiano, Ralph J, Jr., Lawton, Jennifer S, Maffit, Sara K, Schuessler, Richard B, Sellitto, Angela D   +5 more
core   +2 more sources

Effects of cromakalim (BRL 34915) on potassium conductances in CA3 neurons of the guinea-pig hippocampus in vitro [PDF]

, 1989
The action of the potassium channel activator, cromakalim (BRL 34915), on membrane potential, input resistance and current-voltage-relationship of CA3 neurons in a slice preparation of the guinea-pig hippocampus was investigated by means of intracellular
Alzheimer, Christian, Sutor, Bernd, Ten Bruggencate, Gerrit   +2 more
core   +1 more source

Intellectual Disability and Potassium Channelopathies: A Systematic Review

Frontiers in Genetics, 2020
Intellectual disability (ID) manifests prior to adulthood as severe limitations to intellectual function and adaptive behavior. The role of potassium channelopathies in ID is poorly understood.
Miriam Kessi, Miriam Kessi, Miriam Kessi, Miriam Kessi, Baiyu Chen, Baiyu Chen, Jing Peng, Jing Peng, Yulin Tang, Yulin Tang, Eleonore Olatoutou, Eleonore Olatoutou, Fang He, Fang He, Lifen Yang, Lifen Yang, Fei Yin, Fei Yin   +17 more
doaj   +1 more source

Two KCNQ2 Encephalopathy Variants in the Calmodulin-Binding Helix A Exhibit Dominant-Negative Effects and Altered PIP2 Interaction

Frontiers in Physiology, 2020
Heterozygous missense variants in KCNQ2, which encodes the potassium channel subunit Kv7.2, are among the most common genetic causes of severe neonatal-onset epileptic encephalopathy.
Baouyen Tran, Zhi-Gang Ji, Mingxuan Xu, Tammy N. Tsuchida, Edward C. Cooper, Edward C. Cooper, Edward C. Cooper   +6 more
doaj   +1 more source

From pan-reactive KV7 channel opener to subtype selective opener/inhibitor by addition of a methyl group. [PDF]

PLoS ONE, 2014
The voltage-gated potassium channels of the KV7 family (KV7.1-5) play important roles in controlling neuronal excitability and are therefore attractive targets for treatment of CNS disorders linked to hyperexcitability.
Sigrid Marie Blom, Mario Rottländer, Jan Kehler, Christoffer Bundgaard, Nicole Schmitt, Henrik Sindal Jensen   +5 more
doaj   +1 more source

Cardioprotective mechanisms of mitochondria-targeted S-nitrosating agent and adenosine triphosphate-sensitive potassium channel opener are mutually exclusiveCentral MessagePerspective

JTCVS Open, 2021
Background: Myocytes exposed to stress exhibit significant swelling and reduced contractility. These consequences are ameliorated by adenosine triphosphate–sensitive potassium (KATP) channel opener diazoxide (DZX) via an unknown mechanism.
Thaniyyah Ahmad, MD, Jie Wang, MD, Ana Karen Velez, MD, Alejandro Suarez-Pierre, MD, Kathleen C. Clement, MD, Jie Dong, Krisztian Sebestyen, MS, Joseph K. Canner, MHS, Michael P. Murphy, PhD, Jennifer S. Lawton, MD   +9 more
doaj   +1 more source

Selection of medication in hospitalised elderly patients with Angina Pectoris [PDF]

, 2004
Objective: To evaluate medication changes in hospitalised elderly patients diagnosed with angina pectoris and to compare the selection of medication with evidence-based treatment guidelines. Design: Review of medical notes and patient interview. Setting:
Cacciottolo, Joseph M., Gauci, Marise, McElnay, James C.   +2 more
core  

A non-cardiomyocyte autonomous mechanism of cardioprotection involving the SLO1 BK channel [PDF]

, 2013
Opening of BK-type Ca2+ activated K+ channels protects the heart against ischemia-reperfusion (IR) injury. However, the location of BK channels responsible for cardioprotection is debated.
Aldakkak, Aon, Armour, Armour, Armour, Armour, Armour, Baayen, Bednarczyk, Bentzen, Bentzen, Bentzen, Callewaert, Cancherini, Cao, Chen, Chmielewska, Debska, Facundo, Foreman, Franciolini, Fretwell, Garlid, Gribkoff, Haass, Hausenloy, Heinen, Holland, Horackova, Imlach, Jiang, Kawaguchi, Kicinska, Koda, Meera, Meredith, Murphy, Murphy, Nadtochiy, Nadtochiy, Ohya, O’Rourke, O’Rourke, Park, Piwonska, Reid, Rysevaite, Saleh, Salkoff, Shah, Siemen, Singh, Skalska, Tosaka, Tseng-Crank, Vanden Hoek, Wang, Wang, Wenk, Wojtovich, Wojtovich, Wojtovich, Xu, Yuan, Zarei, Zarei, Zoratti   +66 more
core   +1 more source