Results 41 to 50 of about 3,196 (289)
Pharmaceuticals, 2023 Migraine is a highly disabling pain disorder with huge socioeconomic and personal costs. It is genetically heterogenous leading to variability in response to current treatments and frequent lack of response. Thus, new treatment strategies are needed.
Tino Dyhring +3 more
doaj +1 more source
Initial steps in the opening of a Shaker potassium channel [PDF]
Proceedings of the National Academy of Sciences, 2012 The structural model of a K V (K + -selective, voltage-gated) channel in the open state is known (Protein Data Bank ID code 2R9R). Each subunit of the channel has four negatively charged residues distributed in the transmembrane segments S1, S2, and S3 that bind to and facilitate the movement
Toshinori, Hoshi, Clay M, Armstrong
openaire +2 more sources
Effects of cromakalim (BRL 34915) on potassium conductances in CA3 neurons of the guinea-pig hippocampus in vitro [PDF]
, 1989 The action of the potassium channel activator, cromakalim (BRL 34915), on membrane potential, input resistance and current-voltage-relationship of CA3 neurons in a slice preparation of the guinea-pig hippocampus was investigated by means of intracellular
Ten Bruggencate, Gerrit +2 more
core +1 more source
Intellectual Disability and Potassium Channelopathies: A Systematic Review
Frontiers in Genetics, 2020 Intellectual disability (ID) manifests prior to adulthood as severe limitations to intellectual function and adaptive behavior. The role of potassium channelopathies in ID is poorly understood.
Miriam Kessi +17 more
doaj +1 more source
Frontiers in Physiology, 2020 Heterozygous missense variants in KCNQ2, which encodes the potassium channel subunit Kv7.2, are among the most common genetic causes of severe neonatal-onset epileptic encephalopathy.
Baouyen Tran +6 more
doaj +1 more source
From pan-reactive KV7 channel opener to subtype selective opener/inhibitor by addition of a methyl group. [PDF]
PLoS ONE, 2014 The voltage-gated potassium channels of the KV7 family (KV7.1-5) play important roles in controlling neuronal excitability and are therefore attractive targets for treatment of CNS disorders linked to hyperexcitability.
Sigrid Marie Blom +5 more
doaj +1 more source
Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface
FEBS Open Bio, EarlyView.HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana +5 more
wiley +1 more source
The distribution and function of the ATP-sensitive potassium channel subunit Kir6.1 in cardiac and skeletal muscle cell lines. [PDF]
, 2007 ATP-sensitive potassium channels (KAtp) are present in the plasma membrane of a number of tissues but are also present on endomembranes such as the endoplasmic reticulum (ER) and mitochondria.
Ng, K-E.
core
JTCVS Open, 2021 Background: Myocytes exposed to stress exhibit significant swelling and reduced contractility. These consequences are ameliorated by adenosine triphosphate–sensitive potassium (KATP) channel opener diazoxide (DZX) via an unknown mechanism.
Thaniyyah Ahmad, MD +9 more
doaj +1 more source
Potassium channel gating: Not an open and shut case [PDF]
Proceedings of the National Academy of Sciences, 2010 Potassium channels are highly complex molecular systems that modulate the cell potential in response to extracellular or intracellular signals. In multicellular organisms, K+ currents are essential to electrical signaling, governing central nervous system, cardiac, renal, and a host of other organ functions.
Raymond S, Norton, Jacqueline M, Gulbis
openaire +2 more sources