Levosimendan-Induced Venodilation is Mediated by Opening of Potassium Channels [PDF]
ESC Heart Failure, 2021 Abstract Unique vascular responses adhere to the cardiovascular efficacy of the inodilator levosimendan. In particular, selective venodilation appears to explain its clinical benefit during pulmonary hypertension complicated by heart failure with preserved ejection fraction.
Daniel Burkhoff +3 more
openaire +3 more sources
Pharmacodynamics of potassium channel openers in cultured neuronal networks [PDF]
, 2014 Article discussing pharmacodynamics of potassium channel openers in cultured neuronal ...
Gopal, Kamakshi V. +4 more
core +1 more source
Open channel block of Kv1.4 potassium channels by aripiprazole
The Korean Journal of Physiology & Pharmacology, 2020 Aripiprazole is a quinolinone derivative approved as an atypical antipsychotic drug for the treatment of schizophrenia and bipolar disorder. It acts as with partial agonist activities at the dopamine D2 receptors. Although it is known to be relatively safe for patients with cardiac ailments, less is known about the effect of aripiprazole on voltage ...
Park, Jeaneun +4 more
openaire +3 more sources
The periprocedural myocardial damage prevention during elective percutaneous coronary intervention as a result of pharmacological preconditioning with an oral form of nicorandil in patients with stable coronary artery disease. Pilot study [PDF]
Терапевтический архив, 2018 The purpose of the study is to prove the effectiveness of pharmacological preconditioning caused by nicorandil in patients with stable coronary heart disease (CHD) during the elective percutaneous coronary intervention (PCI). Materials and methods.
R V Gostishchev +4 more
doaj +1 more source
Potassium channel openers are uncoupling protonophores: implication in cardioprotection [PDF]
, 2004 Excessive build-up of mitochondrial protonic potential is harmful to cellular homeostasis, and modulation of inner membrane permeability a proposed countermeasure.
Alexander Komarov +11 more
core +1 more source
Do KATP channels open as a prominent and early feature during ischaemia in the Langendorff-perfused rat heart? [PDF]
, 2000 The objective was to investigate whether myocardial adenosine triphosphate-sensitive K<sup>+</sup> (K<sub>ATP</sub>) channels open during the first 10 min of regional ischaemia in Langendorff-perfused rat hearts.
Northover, B.J. +2 more
core +1 more source
Potassium channel openers as potential therapeutic weapons in ion channel disease [PDF]
, 2000 Potassium channel openers as potential therapeutic weapons in ion channel disease. The opening of potassium (K+) channels, causing hyperpolarization of the cell membrane, is a physiological means of decreasing cell excitability.
Lawson, Kim
core +1 more source
KCNQ channel openers reverse depressive symptoms via an active resilience mechanism
Nature Communications, 2016 Potassium channels in the ventral tegmental area are known to regulate resilience against stress-induced depression. Here, the authors show over expression of KCNQ3 channels in VTA dopaminergic neurons or treatment with KCNQ channel openers normalizes ...
Allyson K. Friedman +14 more
doaj +1 more source
Synthesis and vasorelaxant activity of new 1,4-benzoxazine derivatives potassium channel openers. [PDF]
, 2002 As part of a search for new potassium channel openers, the synthesis and vasorelaxant activity of new 1,4-benzoxazine derivatives derived from transformation of the benzopyran skeleton of cromakalim were described.
SEVERINO B +8 more
core +3 more sources
Activation of Peripheral KCNQ Channels Attenuates Inflammatory Pain
Molecular Pain, 2014 Background: Refractory chronic pain dramatically reduces the quality of life of patients. Existing drugs cannot fully achieve effective chronic pain control because of their lower efficacy and/or accompanying side effects.
Hiroki Hayashi +3 more
doaj +1 more source