Enhancement of K+ conductance improves in vitro the contraction force of skeletal muscle in hypokalemic periodic paralysis [PDF]
, 1990 An abnormal ratio between Na+ and K+ conductances seems to be the cause for the depolarization and paralysis of skeletal muscle in primary hypokalemic periodic paralysis.
Ballanyi +19 more
core +1 more source
Antidepressive and anxiolytic effects of ostruthin, a TREK-1 channel activator [PDF]
, 2018 We screened a library of botanical compounds purified from plants of Vietnam for modulators of the activity of a two-pore domain K+ channel, TREK-1, and we identified a hydroxycoumarin-related compound, ostruthin, as an activator of this channel ...
Joseph, Ancy +3 more
core +2 more sources
Alpha and omega in potassium‐channel opening [PDF]
Acta Physiologica, 2018 n ...
openaire +3 more sources
K+ channel openers restore verapamil-inhibited lung fluid resolution and transepithelial ion transport [PDF]
, 2010 Background: Lung epithelial Na+ channels (ENaC) are regulated by cell Ca2+ signal, which may contribute to calcium antagonist-induced noncardiogenic lung edema.
Dong-Yun Han +8 more
core +4 more sources
KCNQ channel openers reverse depressive symptoms via an active resilience mechanism
Nature Communications, 2016 Potassium channels in the ventral tegmental area are known to regulate resilience against stress-induced depression. Here, the authors show over expression of KCNQ3 channels in VTA dopaminergic neurons or treatment with KCNQ channel openers normalizes ...
Allyson K. Friedman +14 more
doaj +1 more source
BK channel activators and their therapeutic perspectives [PDF]
, 2014 The large conductance calcium- and voltage-activated K(+) channel (KCa1.1, BK, MaxiK) is ubiquitously expressed in the body, and holds the ability to integrate changes in intracellular calcium and membrane potential.
Bo H. Bentzen +3 more
core +1 more source
The envenomation of general physiology throughout the last century. [PDF]
, 2017 Toxins are the poisonous products of organisms. Toxins serve vital defensive and offensive functions for those that harbor them: stinging scorpions, pesticidal plants, sanguinary snakes, fearless frogs, sliming snails, noxious newts, and smarting spiders.
Sack, Jon T
core +1 more source
Activation of Peripheral KCNQ Channels Attenuates Inflammatory Pain
Molecular Pain, 2014 Background: Refractory chronic pain dramatically reduces the quality of life of patients. Existing drugs cannot fully achieve effective chronic pain control because of their lower efficacy and/or accompanying side effects.
Hiroki Hayashi +3 more
doaj +1 more source
Modulation of mitochondrial respiratory function and ROS production by novel benzopyran analogues [PDF]
, 2015 A substantial body of evidence indicates that pharmacological activation of mitochondrial ATP-sensitive potassium channels (mKATP) in the heart is protective in conditions associated with ischemia/reperfusion injury.
Bazckó, István +8 more
core +1 more source
Open channel block of Kv1.4 potassium channels by aripiprazole
The Korean Journal of Physiology & Pharmacology, 2020 Aripiprazole is a quinolinone derivative approved as an atypical antipsychotic drug for the treatment of schizophrenia and bipolar disorder. It acts as with partial agonist activities at the dopamine D2 receptors. Although it is known to be relatively safe for patients with cardiac ailments, less is known about the effect of aripiprazole on voltage ...
Park, Jeaneun +4 more
openaire +3 more sources