Results 31 to 40 of about 1,524,654 (239)

Intellectual Disability and Potassium Channelopathies: A Systematic Review

Frontiers in Genetics, 2020
Intellectual disability (ID) manifests prior to adulthood as severe limitations to intellectual function and adaptive behavior. The role of potassium channelopathies in ID is poorly understood.
Miriam Kessi, Miriam Kessi, Miriam Kessi, Miriam Kessi, Baiyu Chen, Baiyu Chen, Jing Peng, Jing Peng, Yulin Tang, Yulin Tang, Eleonore Olatoutou, Eleonore Olatoutou, Fang He, Fang He, Lifen Yang, Lifen Yang, Fei Yin, Fei Yin   +17 more
doaj   +1 more source

Two KCNQ2 Encephalopathy Variants in the Calmodulin-Binding Helix A Exhibit Dominant-Negative Effects and Altered PIP2 Interaction

Frontiers in Physiology, 2020
Heterozygous missense variants in KCNQ2, which encodes the potassium channel subunit Kv7.2, are among the most common genetic causes of severe neonatal-onset epileptic encephalopathy.
Baouyen Tran, Zhi-Gang Ji, Mingxuan Xu, Tammy N. Tsuchida, Edward C. Cooper, Edward C. Cooper, Edward C. Cooper   +6 more
doaj   +1 more source

From pan-reactive KV7 channel opener to subtype selective opener/inhibitor by addition of a methyl group. [PDF]

PLoS ONE, 2014
The voltage-gated potassium channels of the KV7 family (KV7.1-5) play important roles in controlling neuronal excitability and are therefore attractive targets for treatment of CNS disorders linked to hyperexcitability.
Sigrid Marie Blom, Mario Rottländer, Jan Kehler, Christoffer Bundgaard, Nicole Schmitt, Henrik Sindal Jensen   +5 more
doaj   +1 more source

The distribution and function of the ATP-sensitive potassium channel subunit Kir6.1 in cardiac and skeletal muscle cell lines. [PDF]

, 2007
ATP-sensitive potassium channels (KAtp) are present in the plasma membrane of a number of tissues but are also present on endomembranes such as the endoplasmic reticulum (ER) and mitochondria.
Ng, K-E.
core  

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Cardioprotective mechanisms of mitochondria-targeted S-nitrosating agent and adenosine triphosphate-sensitive potassium channel opener are mutually exclusiveCentral MessagePerspective

JTCVS Open, 2021
Background: Myocytes exposed to stress exhibit significant swelling and reduced contractility. These consequences are ameliorated by adenosine triphosphate–sensitive potassium (KATP) channel opener diazoxide (DZX) via an unknown mechanism.
Thaniyyah Ahmad, MD, Jie Wang, MD, Ana Karen Velez, MD, Alejandro Suarez-Pierre, MD, Kathleen C. Clement, MD, Jie Dong, Krisztian Sebestyen, MS, Joseph K. Canner, MHS, Michael P. Murphy, PhD, Jennifer S. Lawton, MD   +9 more
doaj   +1 more source

Potassium channel openers: The case of BK channel activators

, 2006
Large-conductance calcium-activated potassium channels, also known as BK or Maxi-K channels, occur in many types of cells, where they play an essential role in the regulation of cell excitability and function.
Nardi A, Olesen SP, CALDERONE, VINCENZO
core   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Binding of ATP-Sensitive Potassium Channel (K_ATP) Openers to Cardiac Membranes:  Correlation of Binding Affinities with Cardioprotective and Smooth Muscle Relaxing Potencies

, 2016
Binding of ATP-Sensitive Potassium Channel (KATP) Openers to Cardiac Membranes:  Correlation of Binding Affinities with Cardioprotective and Smooth Muscle Relaxing ...
Nicholas J. Lodge (2252563), Karnail S. Atwal (2403862), Sarah C. Traeger (1622287), Gary J. Grover (2375041), Diane E. Normandin (3014127), Paul G. Sleph (2065084), Catherine C. Bryson (3021468), Robert B. Cohen (3021471), Keneth E. J. Dickinson (3021465)   +8 more
core   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source