Results 11 to 20 of about 2,645 (252)
Involvement of Potassium Channel Signalling in Migraine Pathophysiology
Pharmaceuticals, 2023 Migraine is a primary headache disorder ranked as the leading cause of years lived with disability among individuals younger than 50 years. The aetiology of migraine is complex and might involve several molecules of different signalling pathways ...
Mohammad Al-Mahdi Al-Karagholi
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Frontiers in Neuroscience, 2022 Tinnitus is the phantom perception of sound that has no external source. A neurological signature of tinnitus, and the frequently associated hyperacusis, is an imbalance between excitatory and inhibitory activity in the central auditory system (CAS ...
Luisa L. Scott +9 more
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Mitochondrial Potassium Channels as Druggable Targets
Biomolecules, 2020 Mitochondrial potassium channels have been described as important factors in cell pro-life and death phenomena. The activation of mitochondrial potassium channels, such as ATP-regulated or calcium-activated large conductance potassium channels, may have ...
Antoni Wrzosek +3 more
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Convergence of Multiple Stimuli to a Single Gate in TREK1 and TRAAK Potassium Channels
Frontiers in Pharmacology, 2021 Inhibitory potassium channels of the TREK1/TRAAK family are integrators of multiple stimuli, including temperature, membrane stretch, polyunsaturated fatty acids and pH.
Frank S Choveau +5 more
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Open-State Models of a Potassium Channel [PDF]
Biophysical Journal, 2002 The structure of the bacterial potassium channel, KcsA, corresponds to the channel in a closed state. Two lines of evidence suggest that the channel must widen its intracellular mouth when in an open state: 1) internal block by a series of tetraalkylammonium ions and 2) spin labeling experiments.
Biggin, P, Sansom, MS
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IBRO Neuroscience Reports, 2022 Introduction: slowly adapting mechanoreceptors in the skin provide vital tactile information to animals. The ionic channels that underlie their functioning is the subject of intense research.
Peter M.B. Cahusac, Solomon S. Senok
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Current Therapeutic Research, 2023 : Background: Cilnidipine is a fourth-generation calcium channel blocker that is clinically used to treat hypertension. It is a dihydropyridine that blocks L- and N-type calcium channels.
Steffi A. Maria, MD +4 more
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The Mitochondrial K Channel as a Receptor for Potassium Channel Openers [PDF]
Journal of Biological Chemistry, 1996 The biochemical properties of the mitochondrial KATP channel are very similar to those of plasma membrane KATP channels, including inhibition by low concentrations of ATP and glyburide (Paucek, P., Mironova, G., Mahdi, F., Beavis, A. D., Woldegiorgis, G., and Garlid, K. D. (1992) J. Biol. Chem. 267, 26062-26069).
K D, Garlid +4 more
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Multidimensional Regulation of Cardiac Mitochondrial Potassium Channels
Cells, 2021 Mitochondria play a fundamental role in the energetics of cardiac cells. Moreover, mitochondria are involved in cardiac ischemia/reperfusion injury by opening the mitochondrial permeability transition pore which is the major cause of cell death.
Bogusz Kulawiak +2 more
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Potassium channels as drugs targets in therapy of cardiovascular diseases: 25 years later [PDF]
Sanamed, 2013 Potassium channels are the most variable ion channel group. They participate in numerous cardiovascular functions, for example regulation of vascular tone, maintenance of resting cardiac membrane potential and excitability of cardiac conduction tissue ...
Protić Dragana +2 more
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