Results 11 to 20 of about 1,524,654 (239)

Effect of Potassium Channel Modulators on Morphine Withdrawal in Mice

Substance Abuse: Research and Treatment, 2010
The present study was conducted to investigate the effect of potassium channel openers and blockers on morphine withdrawal syndrome. Mice were rendered dependent on morphine by subcutaneous injection of morphine; four hours later, withdrawal was induced ...
Vikas Seth, Mushtaq Ahmad, Prerna Upadhyaya, Monika Sharma, Vijay Moghe   +4 more
doaj   +3 more sources

Potassium channels as drugs targets in therapy of cardiovascular diseases: 25 years later [PDF]

Sanamed, 2013
Potassium channels are the most variable ion channel group. They participate in numerous cardiovascular functions, for example regulation of vascular tone, maintenance of resting cardiac membrane potential and excitability of cardiac conduction tissue ...
Protić Dragana, Todorović Zoran, Gojković-Bukarica Ljiljana   +2 more
doaj   +4 more sources

Isoform-Selective KCNA1 Potassium Channel Openers Built from Glycine. [PDF]

J Pharmacol Exp Ther, 2020
Loss of function of voltage-gated potassium (Kv) channels is linked to a range of lethal or debilitating channelopathies. New pharmacological approaches are warranted to isoform-selectively activate specific Kv channels.
Manville RW, Abbott GW.
europepmc   +2 more sources

Mitochondrial potassium channel opener diazoxide preserves neuronal-vascular function after cerebral ischemia in newborn pigs [PDF]

, 1999
Background and Purpose-N-Methyl-D-aspartate (NMDA) elicits neuronally mediated cerebral arteriolar vasodilation that is reduced by ischemia/reperfusion (I/R).
David W. Busija, Perciaccante, J. V., Ferenc Domoki, James V. Perciaccante, Domoki, Ferenc, Bari, Ferenc, Ferenc Bari, Roland Veltkamp, Veltkamp, R.   +8 more
core   +2 more sources

Small molecule modulation of the large-conductance calcium-activated potassium channel suppresses salicylate-induced tinnitus in mice

Frontiers in Neuroscience, 2022
Tinnitus is the phantom perception of sound that has no external source. A neurological signature of tinnitus, and the frequently associated hyperacusis, is an imbalance between excitatory and inhibitory activity in the central auditory system (CAS ...
Luisa L. Scott, Andrea S. Lowe, Andrea S. Lowe, Elliott J. Brecht, Elliott J. Brecht, Luis Franco-Waite, Luis Franco-Waite, Joseph P. Walton, Joseph P. Walton, Joseph P. Walton   +9 more
doaj   +1 more source

Mitochondrial Potassium Channels as Druggable Targets

Biomolecules, 2020
Mitochondrial potassium channels have been described as important factors in cell pro-life and death phenomena. The activation of mitochondrial potassium channels, such as ATP-regulated or calcium-activated large conductance potassium channels, may have ...
Antoni Wrzosek, Bartłomiej Augustynek, Monika Żochowska, Adam Szewczyk   +3 more
doaj   +1 more source

Convergence of Multiple Stimuli to a Single Gate in TREK1 and TRAAK Potassium Channels

Frontiers in Pharmacology, 2021
Inhibitory potassium channels of the TREK1/TRAAK family are integrators of multiple stimuli, including temperature, membrane stretch, polyunsaturated fatty acids and pH.
Frank S Choveau, Ismail Ben Soussia, Delphine Bichet, Chatelain C. Franck, Sylvain Feliciangeli, Florian Lesage   +5 more
doaj   +1 more source

Effects of potassium channel modulators on the responses of mammalian slowly adapting mechanoreceptors

IBRO Neuroscience Reports, 2022
Introduction: slowly adapting mechanoreceptors in the skin provide vital tactile information to animals. The ionic channels that underlie their functioning is the subject of intense research.
Peter M.B. Cahusac, Solomon S. Senok
doaj   +1 more source

Inhibition of Contractility of Isolated Caprine Detrusor by the Calcium Channel Blocker Cilnidipine and Reversal by Calcium Channel Openers

Current Therapeutic Research, 2023
: Background: Cilnidipine is a fourth-generation calcium channel blocker that is clinically used to treat hypertension. It is a dihydropyridine that blocks L- and N-type calcium channels.
Steffi A. Maria, MD, Aniket Kumar, PhD, Premila M. Wilfred, MD, Margaret Shanthi, MD, Jacob Peedicayil, MD   +4 more
doaj   +1 more source

Multidimensional Regulation of Cardiac Mitochondrial Potassium Channels

Cells, 2021
Mitochondria play a fundamental role in the energetics of cardiac cells. Moreover, mitochondria are involved in cardiac ischemia/reperfusion injury by opening the mitochondrial permeability transition pore which is the major cause of cell death.
Bogusz Kulawiak, Piotr Bednarczyk, Adam Szewczyk   +2 more
doaj   +1 more source