Results 11 to 20 of about 3,196 (289)
Effect of Potassium Channel Modulators on Morphine Withdrawal in Mice [PDF]
Substance Abuse: Research and Treatment, 2010 The present study was conducted to investigate the effect of potassium channel openers and blockers on morphine withdrawal syndrome. Mice were rendered dependent on morphine by subcutaneous injection of morphine; four hours later, withdrawal was induced ...
Vikas Seth +4 more
doaj +4 more sources
ATP-sensitive potassium (KATP) channel openers diazoxide and nicorandil lower intraocular pressure by activating the Erk1/2 signaling pathway. [PDF]
PLoS ONE, 2017 Elevated intraocular pressure is the most prevalent and only treatable risk factor for glaucoma, a degenerative disease of the optic nerve. While treatment options to slow disease progression are available, all current therapeutic and surgical treatments
Uttio Roy Chowdhury +3 more
doaj +3 more sources
Isoform-Selective KCNA1 Potassium Channel Openers Built from Glycine. [PDF]
J Pharmacol Exp Ther, 2020 Loss of function of voltage-gated potassium (Kv) channels is linked to a range of lethal or debilitating channelopathies. New pharmacological approaches are warranted to isoform-selectively activate specific Kv channels.
Manville RW, Abbott GW.
europepmc +3 more sources
Effect of ATP-sensitive Potassium Channel Openers on Intraocular Pressure in Ocular Hypertensive Animal Models. [PDF]
Invest Ophthalmol Vis Sci, 2022 Purpose: To evaluate the effect of ATP-sensitive potassium channel openers cromakalim prodrug 1 (CKLP1) and diazoxide on IOP in three independent mouse models of ocular hypertension.
Roy Chowdhury U +6 more
europepmc +3 more sources
Preconditioning with potassium channel openers: [PDF]
The Journal of Thoracic and Cardiovascular Surgery, 1995 Ischemic preconditioning defines an adaptive endogenous mechanism in which a brief episode of reversible ischemia renders the heart more resistant to a subsequent period of sustained ischemia.
Menasché, Philippe +5 more
openaire +3 more sources
Involvement of Potassium Channel Signalling in Migraine Pathophysiology
Pharmaceuticals, 2023 Migraine is a primary headache disorder ranked as the leading cause of years lived with disability among individuals younger than 50 years. The aetiology of migraine is complex and might involve several molecules of different signalling pathways ...
Mohammad Al-Mahdi Al-Karagholi
doaj +1 more source
Frontiers in Neuroscience, 2022 Tinnitus is the phantom perception of sound that has no external source. A neurological signature of tinnitus, and the frequently associated hyperacusis, is an imbalance between excitatory and inhibitory activity in the central auditory system (CAS ...
Luisa L. Scott +9 more
doaj +1 more source
Mitochondrial Potassium Channels as Druggable Targets
Biomolecules, 2020 Mitochondrial potassium channels have been described as important factors in cell pro-life and death phenomena. The activation of mitochondrial potassium channels, such as ATP-regulated or calcium-activated large conductance potassium channels, may have ...
Antoni Wrzosek +3 more
doaj +1 more source
Convergence of Multiple Stimuli to a Single Gate in TREK1 and TRAAK Potassium Channels
Frontiers in Pharmacology, 2021 Inhibitory potassium channels of the TREK1/TRAAK family are integrators of multiple stimuli, including temperature, membrane stretch, polyunsaturated fatty acids and pH.
Frank S Choveau +5 more
doaj +1 more source
Open-State Models of a Potassium Channel [PDF]
Biophysical Journal, 2002 The structure of the bacterial potassium channel, KcsA, corresponds to the channel in a closed state. Two lines of evidence suggest that the channel must widen its intracellular mouth when in an open state: 1) internal block by a series of tetraalkylammonium ions and 2) spin labeling experiments.
Biggin, P, Sansom, MS
openaire +2 more sources