Results 11 to 20 of about 5,395 (299)

ATP sensitive potassium channel openers: A new class of ocular hypotensive agents. [PDF]

Exp Eye Res, 2017
Roy Chowdhury U, Dosa PI, Fautsch MP.
europepmc   +2 more sources

Alternative Targets for Modulators of Mitochondrial Potassium Channels

Molecules, 2022
Mitochondrial potassium channels control potassium influx into the mitochondrial matrix and thus regulate mitochondrial membrane potential, volume, respiration, and synthesis of reactive oxygen species (ROS).
Antoni Wrzosek, Shur Gałecka, Monika Żochowska, Anna Olszewska, Bogusz Kulawiak   +4 more
doaj   +1 more source

Involvement of Potassium Channel Signalling in Migraine Pathophysiology

Pharmaceuticals, 2023
Migraine is a primary headache disorder ranked as the leading cause of years lived with disability among individuals younger than 50 years. The aetiology of migraine is complex and might involve several molecules of different signalling pathways ...
Mohammad Al-Mahdi Al-Karagholi
doaj   +1 more source

Small molecule modulation of the large-conductance calcium-activated potassium channel suppresses salicylate-induced tinnitus in mice

Frontiers in Neuroscience, 2022
Tinnitus is the phantom perception of sound that has no external source. A neurological signature of tinnitus, and the frequently associated hyperacusis, is an imbalance between excitatory and inhibitory activity in the central auditory system (CAS ...
Luisa L. Scott, Andrea S. Lowe, Andrea S. Lowe, Elliott J. Brecht, Elliott J. Brecht, Luis Franco-Waite, Luis Franco-Waite, Joseph P. Walton, Joseph P. Walton, Joseph P. Walton   +9 more
doaj   +1 more source

Mitochondrial Potassium Channels as Druggable Targets

Biomolecules, 2020
Mitochondrial potassium channels have been described as important factors in cell pro-life and death phenomena. The activation of mitochondrial potassium channels, such as ATP-regulated or calcium-activated large conductance potassium channels, may have ...
Antoni Wrzosek, Bartłomiej Augustynek, Monika Żochowska, Adam Szewczyk   +3 more
doaj   +1 more source

Convergence of Multiple Stimuli to a Single Gate in TREK1 and TRAAK Potassium Channels

Frontiers in Pharmacology, 2021
Inhibitory potassium channels of the TREK1/TRAAK family are integrators of multiple stimuli, including temperature, membrane stretch, polyunsaturated fatty acids and pH.
Frank S Choveau, Ismail Ben Soussia, Delphine Bichet, Chatelain C. Franck, Sylvain Feliciangeli, Florian Lesage   +5 more
doaj   +1 more source

Effects of potassium channel modulators on the responses of mammalian slowly adapting mechanoreceptors

IBRO Neuroscience Reports, 2022
Introduction: slowly adapting mechanoreceptors in the skin provide vital tactile information to animals. The ionic channels that underlie their functioning is the subject of intense research.
Peter M.B. Cahusac, Solomon S. Senok
doaj   +1 more source

Inhibition of Contractility of Isolated Caprine Detrusor by the Calcium Channel Blocker Cilnidipine and Reversal by Calcium Channel Openers

Current Therapeutic Research, 2023
: Background: Cilnidipine is a fourth-generation calcium channel blocker that is clinically used to treat hypertension. It is a dihydropyridine that blocks L- and N-type calcium channels.
Steffi A. Maria, MD, Aniket Kumar, PhD, Premila M. Wilfred, MD, Margaret Shanthi, MD, Jacob Peedicayil, MD   +4 more
doaj   +1 more source

Neuroprotective effects of potassium channel openers on cerebral ischemia–reperfusion injury in diabetic rats

Bulletin of Faculty of Pharmacy Cairo University, 2017
Objectives: This study was done to estimate the potential neuroprotective role of potassium channel openers in cerebral ischemia–reperfusion (IR) injury in streptozotocin (STZ) induced type-I diabetic rats (T1DR).
Anand B. Pithadia, Shital S. Panchal, Denvanshu J. Patel   +2 more
doaj   +1 more source

Multidimensional Regulation of Cardiac Mitochondrial Potassium Channels

Cells, 2021
Mitochondria play a fundamental role in the energetics of cardiac cells. Moreover, mitochondria are involved in cardiac ischemia/reperfusion injury by opening the mitochondrial permeability transition pore which is the major cause of cell death.
Bogusz Kulawiak, Piotr Bednarczyk, Adam Szewczyk   +2 more
doaj   +1 more source