Alternative Targets for Modulators of Mitochondrial Potassium Channels [PDF]
Molecules, 2022 Mitochondrial potassium channels control potassium influx into the mitochondrial matrix and thus regulate mitochondrial membrane potential, volume, respiration, and synthesis of reactive oxygen species (ROS).
Antoni Wrzosek +4 more
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Multidimensional Regulation of Cardiac Mitochondrial Potassium Channels [PDF]
Cells, 2021 Mitochondria play a fundamental role in the energetics of cardiac cells. Moreover, mitochondria are involved in cardiac ischemia/reperfusion injury by opening the mitochondrial permeability transition pore which is the major cause of cell death.
Bogusz Kulawiak +2 more
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Mitochondrial Potassium Channels as Druggable Targets [PDF]
Biomolecules, 2020 Mitochondrial potassium channels have been described as important factors in cell pro-life and death phenomena. The activation of mitochondrial potassium channels, such as ATP-regulated or calcium-activated large conductance potassium channels, may have ...
Antoni Wrzosek +3 more
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Mitochondrial potassium channels: A novel calcitriol target [PDF]
Cellular & Molecular Biology Letters, 2022 Background Calcitriol (an active metabolite of vitamin D) modulates the expression of hundreds of human genes by activation of the vitamin D nuclear receptor (VDR).
Anna M. Olszewska +4 more
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Cardioprotective Effects of Grapefruit IntegroPectin Extracted via Hydrodynamic Cavitation from By-Products of Citrus Fruits Industry: Role of Mitochondrial Potassium Channels [PDF]
Foods, 2022 Citrus flavonoids are well-known for their beneficial effects at the cardiovascular and cardio-metabolic level, but often the encouraging in vitro results are not confirmed by in vivo approaches; in addition, the clinical trials are also inconsistent ...
Lorenzo Flori +7 more
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Understanding mitochondrial potassium channels: 33 years after discovery [PDF]
Acta Biochimica PolonicaMitochondrial investigations have extended beyond their traditional functions, covering areas such as ATP synthesis and metabolism. Mitochondria are now implicated in new functional areas such as cytoprotection, cellular senescence, tumor function and ...
Adam Szewczyk
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Redox Regulation of Mitochondrial Potassium Channels Activity [PDF]
AntioxidantsRedox reactions exert a profound influence on numerous cellular functions with mitochondria playing a central role in orchestrating these processes. This pivotal involvement arises from three primary factors: (1) the synthesis of reactive oxygen species (
Joanna Lewandowska +3 more
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Current Challenges of Mitochondrial Potassium Channel Research
Frontiers in Physiology, 2022 In this paper, the current challenges of mitochondrial potassium channels research were critically reviewed. Even though recent progress in understanding K+ traffic in mitochondria has been substantial, some basic issues of this process remain unresolved.
Bogusz Kulawiak, Adam Szewczyk
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Potential therapeutic targeting of BKCa channels in glioblastoma treatment [PDF]
Molecular OncologyPotassium channels in brain tissue orchestrate essential cellular processes, including the regulation of membrane potential and neuronal excitability. Among them, large‐conductance calcium‐activated potassium (BKCa) channels play a pivotal role in both ...
Kamila Maliszewska‐Olejniczak +4 more
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Methods of Measuring Mitochondrial Potassium Channels: A Critical Assessment [PDF]
International Journal of Molecular Sciences, 2022 Agnieszka Walewska +2 more
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