Results 21 to 30 of about 76,259 (184)

11,12-EET stimulates the association of BK channel α and β(1) subunits in mitochondria to induce pulmonary vasoconstriction. [PDF]

PLoS ONE, 2012
In the systemic circulation, 11,12-epoxyeicosatrienoic acid (11,12-EET) elicits nitric oxide (NO)- and prostacyclin-independent vascular relaxation, partially through the activation of large conductance Ca(2+)-activated potassium (BK) channels.
Annemarieke E Loot, Isabelle Moneke, Benjamin Keserü, Matthias Oelze, Tetyana Syzonenko, Andreas Daiber, Ingrid Fleming   +6 more
doaj   +8 more sources

Signaling pathways targeting mitochondrial potassium channels

International Journal of Biochemistry and Cell Biology, 2020
In this review, we describe key signaling pathways regulating potassium channels present in the inner mitochondrial membrane. The signaling cascades covered here include phosphorylation, redox reactions, modulation by calcium ions and nucleotides. The following types of potassium channels have been identified in the inner mitochondrial membrane of ...
Daria Rotko, Wolfram S Kunz, Adam Szewczyk   +2 more
exaly   +3 more sources

Loss of Potassium and Chloride Transport Changes PM-Induced Epithelial Dysfunction [PDF]

Journal of Inflammation Research
Sandra Jaworowska, Kamila Maliszewska-Olejniczak, Agnieszka Łukasiak, Jakub Hoser, Mirosław Zając, Piotr Bednarczyk Department of Physics and Biophysics, Institute of Biology, Warsaw University of Life Sciences – SGGW ...
Jaworowska S, Maliszewska-Olejniczak K, Łukasiak A, Hoser J, Zając M, Bednarczyk P   +5 more
doaj   +2 more sources

Cardioprotective Properties of Mannitol-Involvement of Mitochondrial Potassium Channels. [PDF]

Int J Mol Sci, 2021
Cardiac preconditioning (PC) and postconditioning (PoC) are powerful measures against the consequences of myocardial ischemia and reperfusion (I/R) injury. Mannitol—a hyperosmolar solution—is clinically used for treatment of intracranial and intraocular pressure or promotion of diuresis in renal failure.
Feige K, Rubbert J, Raupach A, Stroethoff M, Heinen A, Hollmann MW, Huhn R, Torregroza C.   +7 more
europepmc   +3 more sources

Routes for Potassium Ions across Mitochondrial Membranes: A Biophysical Point of View with Special Focus on the ATP-Sensitive K⁺ Channel

Biomolecules, 2021
Potassium ions can cross both the outer and inner mitochondrial membranes by means of multiple routes. A few potassium-permeable ion channels exist in the outer membrane, while in the inner membrane, a multitude of different potassium-selective and ...
Yevheniia Kravenska, Vanessa Checchetto, Ildiko Szabo   +2 more
doaj   +1 more source

Identification of the Large-Conductance Ca²⁺-Regulated Potassium Channel in Mitochondria of Human Bronchial Epithelial Cells

Molecules, 2021
Mitochondria play a key role in energy metabolism within the cell. Potassium channels such as ATP-sensitive, voltage-gated or large-conductance Ca2+-regulated channels have been described in the inner mitochondrial membrane.
Aleksandra Sek, Rafal P. Kampa, Bogusz Kulawiak, Adam Szewczyk, Piotr Bednarczyk   +4 more
doaj   +1 more source

New Mitochondrial Potassium Channels [PDF]

Biophysical Journal, 2014
Mitochondrial potassium channels play an important role in cytoprotection. The following potassium channels have been described in the inner mitochondrial membrane: the ATP-regulated potassium channel, the large conductance calcium activated potassium channel, the voltage-gated potassium channel and the twin-pore domain TASK-3 potassium channel ...
Szewczyk, Adam, Olszewska, Anna, Augustynek, Bartlomiej, Laskowski, Michal, Bednaarczyk, Piotr   +4 more
openaire   +1 more source

Mitochondrial potassium channels in Dictyostelium discoideum [PDF]

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2012
Mitochondria are crucial not only in energy metabolism but also in regulation of cell senescence and apoptosis. The strict control of inner mitochondrial membrane permeability and selective ion transport is essential for mitochondria functioning. Potassium ions homeostasis is an important process for mitochondrial optimal functioning.
Laskowski, Michal, Szewczyk, Adam, Kicinska, Anna, Jarmuszkiewicz, Wieslawa   +3 more
openaire   +1 more source

Putative Structural and Functional Coupling of the Mitochondrial BKCa Channel to the Respiratory Chain. [PDF]

PLoS ONE, 2013
Potassium channels have been found in the inner mitochondrial membranes of various cells. These channels regulate the mitochondrial membrane potential, the matrix volume and respiration. The activation of these channels is cytoprotective.
Piotr Bednarczyk, Mariusz R Wieckowski, Malgorzata Broszkiewicz, Krzysztof Skowronek, Detlef Siemen, Adam Szewczyk   +5 more
doaj   +1 more source

Single channel properties of mitochondrial large conductance potassium channel formed by BK-VEDEC splice variant

Scientific Reports, 2021
The activation of mitochondrial large conductance calcium-activated potassium (mitoBKCa) channels increases cell survival during ischemia/reperfusion injury of cardiac cells.
Shur Gałecka, Bogusz Kulawiak, Piotr Bednarczyk, Harpreet Singh, Adam Szewczyk   +4 more
doaj   +1 more source