Results 21 to 30 of about 38,961 (265)

Routes for Potassium Ions across Mitochondrial Membranes: A Biophysical Point of View with Special Focus on the ATP-Sensitive K⁺ Channel

Biomolecules, 2021
Potassium ions can cross both the outer and inner mitochondrial membranes by means of multiple routes. A few potassium-permeable ion channels exist in the outer membrane, while in the inner membrane, a multitude of different potassium-selective and ...
Yevheniia Kravenska, Vanessa Checchetto, Ildiko Szabo   +2 more
doaj   +1 more source

Identification of the Large-Conductance Ca²⁺-Regulated Potassium Channel in Mitochondria of Human Bronchial Epithelial Cells

Molecules, 2021
Mitochondria play a key role in energy metabolism within the cell. Potassium channels such as ATP-sensitive, voltage-gated or large-conductance Ca2+-regulated channels have been described in the inner mitochondrial membrane.
Aleksandra Sek, Rafal P. Kampa, Bogusz Kulawiak, Adam Szewczyk, Piotr Bednarczyk   +4 more
doaj   +1 more source

Mitochondrial potassium channels in Dictyostelium discoideum [PDF]

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2012
Mitochondria are crucial not only in energy metabolism but also in regulation of cell senescence and apoptosis. The strict control of inner mitochondrial membrane permeability and selective ion transport is essential for mitochondria functioning. Potassium ions homeostasis is an important process for mitochondrial optimal functioning.
Laskowski, Michal, Szewczyk, Adam, Kicinska, Anna, Jarmuszkiewicz, Wieslawa   +3 more
openaire   +1 more source

Putative Structural and Functional Coupling of the Mitochondrial BKCa Channel to the Respiratory Chain. [PDF]

PLoS ONE, 2013
Potassium channels have been found in the inner mitochondrial membranes of various cells. These channels regulate the mitochondrial membrane potential, the matrix volume and respiration. The activation of these channels is cytoprotective.
Piotr Bednarczyk, Mariusz R Wieckowski, Malgorzata Broszkiewicz, Krzysztof Skowronek, Detlef Siemen, Adam Szewczyk   +5 more
doaj   +1 more source

The Mitochondrial K Channel as a Receptor for Potassium Channel Openers [PDF]

Journal of Biological Chemistry, 1996
The biochemical properties of the mitochondrial KATP channel are very similar to those of plasma membrane KATP channels, including inhibition by low concentrations of ATP and glyburide (Paucek, P., Mironova, G., Mahdi, F., Beavis, A. D., Woldegiorgis, G., and Garlid, K. D. (1992) J. Biol. Chem. 267, 26062-26069).
K D, Garlid, P, Paucek, V, Yarov-Yarovoy, X, Sun, P A, Schindler   +4 more
openaire   +2 more sources

Single channel properties of mitochondrial large conductance potassium channel formed by BK-VEDEC splice variant

Scientific Reports, 2021
The activation of mitochondrial large conductance calcium-activated potassium (mitoBKCa) channels increases cell survival during ischemia/reperfusion injury of cardiac cells.
Shur Gałecka, Bogusz Kulawiak, Piotr Bednarczyk, Harpreet Singh, Adam Szewczyk   +4 more
doaj   +1 more source

Postconditioning with D-limonene exerts neuroprotection in rats via enhancing mitochondrial activity

Türk Biyokimya Dergisi, 2023
The key component of neuroprotection after cerebral ischemia–reperfusion (I–R) injury is mitochondrial improvement. By focusing on the function of mitochondrial biogenesis and ATP-sensitive potassium (mK–ATP) channels and inflammatory responses, the ...
Zhang Leguo, Zhao Zeyu, Jia Jianpu, Zhang Liran, Xia Ruixue, Zhu Cuimin   +5 more
doaj   +1 more source

Pharmacological Characterization of a Recombinant Mitochondrial ROMK2 Potassium Channel Expressed in Bacteria and Reconstituted in Planar Lipid Bilayers

Membranes, 2023
In the inner mitochondrial membrane, several potassium channels that play a role in cell life and death have been identified. One of these channels is the ATP-regulated potassium channel (mitoKATP).
Milena Krajewska, Adam Szewczyk, Bogusz Kulawiak, Piotr Koprowski   +3 more
doaj   +1 more source

The Mitochondrial Routing of the Kv1.3 Channel

Frontiers in Oncology, 2022
Voltage-gated potassium channels control neuronal excitability and cardiac action potentials. In addition, these proteins are involved in a myriad of cellular processes.
Jesusa Capera, Jesusa Capera, María Navarro-Pérez, Anne Stine Moen, Ildiko Szabó, Antonio Felipe   +5 more
doaj   +1 more source

New Mitochondrial Potassium Channels [PDF]

Biophysical Journal, 2014
Mitochondrial potassium channels play an important role in cytoprotection. The following potassium channels have been described in the inner mitochondrial membrane: the ATP-regulated potassium channel, the large conductance calcium activated potassium channel, the voltage-gated potassium channel and the twin-pore domain TASK-3 potassium channel ...
Szewczyk, Adam, Olszewska, Anna, Augustynek, Bartlomiej, Laskowski, Michal, Bednaarczyk, Piotr   +4 more
openaire   +1 more source