Results 31 to 40 of about 38,961 (265)
Biomedicines, 2023 Modulation of mitochondrial K channels represents a pharmacological strategy to promote cardioprotective effects. Isothiocyanates emerge as molecules capable of releasing hydrogen sulfide (H2S), an endogenous pleiotropic gasotransmitter responsible for ...
Lorenzo Flori +10 more
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Mitochondrial potassium channels - an overview.
Postepy biochemii, 2019 Mitochondria play a fundamental role in ATP synthesis within the majority of mammalian cells. Potassium channels present in the inner mitochondrial membrane are fine regulators of mitochondrial function, based on inner membrane K+ permeability. These channels are regulated by a plethora of factors and conditions in a way similar to plasma membrane ...
Adam, Szewczyk +13 more
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Mechanosensitivity of Mitochondrial Potassium Channels [PDF]
Biophysical Journal, 2017 Mitochondria are known for their unique membrane architecture with the inner membrane folded into cristae. It is also known for long that mitochondria undergo drastic changes in volume. These volume changes depend on potassium fluxes. Influx via mitochondrial potassium channels (e.g.
Piotr Koprowski +3 more
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The uniqueness of the plant mitochondrial potassium channel
BMB Reports, 2013 The ATP-inhibited Plant Mitochondrial K(+) Channel (PmitoKATP) was discovered about fifteen years ago in Durum Wheat Mitochondria (DWM). PmitoKATP catalyses the electrophoretic K(+) uniport through the inner mitochondrial membrane; moreover, the co-operation between PmitoKATP and K(+)/H(+) antiporter allows such a great operation of a K(+) cycle to ...
PASTORE, DONATO +3 more
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Identification of putative potassium channel homologues in pathogenic protozoa [PDF]
, 2012 K(+) channels play a vital homeostatic role in cells and abnormal activity of these channels can dramatically alter cell function and survival, suggesting that they might be attractive drug targets in pathogenic organisms.
Prole, D L +3 more
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Cell & Bioscience, 2020 Background Openers of mitochondrial adenosine triphosphate-dependent potassium (mKATP) channels like diazoxide increase reactive oxygen species (ROS) production in cardiac cells and reduce Ca2+ elevations produced by ischemia–reperfusion, protecting the ...
Joice T. Gavali +3 more
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BK in Double-Membrane Organelles: A Biophysical, Pharmacological, and Functional Survey
Frontiers in Physiology, 2021 In the 1970s, calcium-activated potassium currents were recorded for the first time. In 10years, this Ca2+-activated potassium channel was identified in rat skeletal muscle, chromaffin cells and characterized in skeletal muscle membranes reconstituted in
Naileth González-Sanabria +4 more
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KCNMA1 encoded cardiac BK channels afford protection against ischemia-reperfusion injury. [PDF]
PLoS ONE, 2014 Mitochondrial potassium channels have been implicated in myocardial protection mediated through pre-/postconditioning. Compounds that open the Ca2+- and voltage-activated potassium channel of big-conductance (BK) have a pre-conditioning-like effect on ...
Ewa Soltysinska +20 more
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SLO-2 is cytoprotective and contributes to mitochondrial potassium transport. [PDF]
PLoS ONE, 2011 Mitochondrial potassium channels are important mediators of cell protection against stress. The mitochondrial large-conductance "big" K(+) channel (mBK) mediates the evolutionarily-conserved process of anesthetic preconditioning (APC), wherein exposure ...
Andrew P Wojtovich +5 more
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Frontiers in Plant Science, 2015 In plants, the existence of a mitochondrial potassium channel was firstly demonstrated about fifteen years ago in durum wheat as an ATP-dependent potassium channel (PmitoKATP).
Daniela eTrono +4 more
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