Results 31 to 40 of about 38,197 (138)
Cell & Bioscience, 2020 Background Openers of mitochondrial adenosine triphosphate-dependent potassium (mKATP) channels like diazoxide increase reactive oxygen species (ROS) production in cardiac cells and reduce Ca2+ elevations produced by ischemia–reperfusion, protecting the ...
Joice T. Gavali +3 more
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BK in Double-Membrane Organelles: A Biophysical, Pharmacological, and Functional Survey
Frontiers in Physiology, 2021 In the 1970s, calcium-activated potassium currents were recorded for the first time. In 10years, this Ca2+-activated potassium channel was identified in rat skeletal muscle, chromaffin cells and characterized in skeletal muscle membranes reconstituted in
Naileth González-Sanabria +4 more
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Mitochondrial potassium and chloride channels.
Acta Biochimica Polonica, 2000 Channels selective for potassium or chloride ions are present in inner mitochondrial membranes. They probably play an important role in mitochondrial events such as the formation of delta pH and regulation of mitochondrial volume changes. Mitochondrial potassium and chloride channels could also be the targets for pharmacologically active compounds such
A, Kicińska +3 more
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Flavonoids as Natural Modulators of Mitochondrial Potassium Channel [PDF]
Biophysical Journal, 2017 Flavonoids belong to a vast group of polyphenolic compounds that are widely distributed in all foods of plant origin. They exhibit a large variety of biological properties. Interest in health benefits of flavonoids has increased due to their potent antioxidant and free-radical scavenging activities.
Piotr Bednarczyk +4 more
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KCNMA1 encoded cardiac BK channels afford protection against ischemia-reperfusion injury. [PDF]
PLoS ONE, 2014 Mitochondrial potassium channels have been implicated in myocardial protection mediated through pre-/postconditioning. Compounds that open the Ca2+- and voltage-activated potassium channel of big-conductance (BK) have a pre-conditioning-like effect on ...
Ewa Soltysinska +20 more
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SLO-2 is cytoprotective and contributes to mitochondrial potassium transport. [PDF]
PLoS ONE, 2011 Mitochondrial potassium channels are important mediators of cell protection against stress. The mitochondrial large-conductance "big" K(+) channel (mBK) mediates the evolutionarily-conserved process of anesthetic preconditioning (APC), wherein exposure ...
Andrew P Wojtovich +5 more
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Frontiers in Plant Science, 2015 In plants, the existence of a mitochondrial potassium channel was firstly demonstrated about fifteen years ago in durum wheat as an ATP-dependent potassium channel (PmitoKATP).
Daniela eTrono +4 more
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Mitochondrial ATP-Dependent Potassium Channels [PDF]
Circulation, 1998 Background—Brief interruptions of coronary blood flow paradoxically protect the heart from subsequent prolonged ischemia. The basis of such endogenous cardioprotection, known as “ischemic preconditioning,” remains uncertain. Pharmacological evidence has implicated ATP-dependent potassium (KATP) channels in the mechanism of preconditioning; however, the
Y, Liu, T, Sato, B, O'Rourke, E, Marban
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Redox Biology, 2014 Reductions in the blood supply produce considerable injury if the duration of ischemia is prolonged. Paradoxically, restoration of perfusion to ischemic organs can exacerbate tissue damage and extend the size of an evolving infarct.
Theodore Kalogeris +2 more
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Mitochondrial potassium channels: From pharmacology to function
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2006 Mitochondrial potassium channels, such as ATP-regulated or large conductance Ca2+ -activated and voltage gated channels were implicated in cytoprotective phenomenon in different tissues. Basic effects of these channels activity include changes in mitochondrial matrix volume, mitochondrial respiration and membrane potential, and generation of reactive ...
Szewczyk, Adam +6 more
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