Results 31 to 40 of about 76,259 (184)
Membranes, 2023 In the inner mitochondrial membrane, several potassium channels that play a role in cell life and death have been identified. One of these channels is the ATP-regulated potassium channel (mitoKATP).
Milena Krajewska +3 more
doaj +1 more source
Mechanosensitivity of Mitochondrial Potassium Channels [PDF]
Biophysical Journal, 2017 Mitochondria are known for their unique membrane architecture with the inner membrane folded into cristae. It is also known for long that mitochondria undergo drastic changes in volume. These volume changes depend on potassium fluxes. Influx via mitochondrial potassium channels (e.g.
Piotr Koprowski +3 more
openaire +1 more source
Postconditioning with D-limonene exerts neuroprotection in rats via enhancing mitochondrial activity
Türk Biyokimya Dergisi, 2023 The key component of neuroprotection after cerebral ischemia–reperfusion (I–R) injury is mitochondrial improvement. By focusing on the function of mitochondrial biogenesis and ATP-sensitive potassium (mK–ATP) channels and inflammatory responses, the ...
Zhang Leguo +5 more
doaj +1 more source
The Mitochondrial Routing of the Kv1.3 Channel
Frontiers in Oncology, 2022 Voltage-gated potassium channels control neuronal excitability and cardiac action potentials. In addition, these proteins are involved in a myriad of cellular processes.
Jesusa Capera +5 more
doaj +1 more source
The Sodium Channel B4-Subunits are Dysregulated in Temporal Lobe Epilepsy Drug-Resistant Patients [PDF]
, 2020 Temporal lobe epilepsy (TLE) is the most common type of partial epilepsy referred for surgery due to antiepileptic drug (AED) resistance. A common molecular target for many of these drugs is the voltage-gated sodium channel (VGSC).
Falciani, Francesco +4 more
core +1 more source
Biomedicines, 2023 Modulation of mitochondrial K channels represents a pharmacological strategy to promote cardioprotective effects. Isothiocyanates emerge as molecules capable of releasing hydrogen sulfide (H2S), an endogenous pleiotropic gasotransmitter responsible for ...
Lorenzo Flori +10 more
doaj +1 more source
The microbiologist’s guide to membrane potential dynamics [PDF]
, 2020 All cellular membranes have the functionality of generating and maintaining the gradients of electrical and electrochemical potentials. Such potentials were generally thought to be an essential but homeostatic contributor to complex bacterial behaviors ...
Asally, Munehiro, Benarroch, Jonatan M.
core +1 more source
Regulation of Proliferation by a Mitochondrial Potassium Channel in Pancreatic Ductal Adenocarcinoma Cells [PDF]
, 2017 Previous results link the mitochondrial potassium channel Kv1.3 (mitoKv1.3) to the regulation of apoptosis. By synthesizing new, mitochondria-targeted derivatives (PAPTP and PCARBTP) of PAP-1, a specific membrane-permeant Kv1.3 inhibitor, we have ...
Amigorena +48 more
core +2 more sources
Mitochondrial potassium channels - an overview.
Postepy biochemii, 2019 Mitochondria play a fundamental role in ATP synthesis within the majority of mammalian cells. Potassium channels present in the inner mitochondrial membrane are fine regulators of mitochondrial function, based on inner membrane K+ permeability. These channels are regulated by a plethora of factors and conditions in a way similar to plasma membrane ...
Adam, Szewczyk +13 more
openaire +3 more sources
Mitochondrial potassium channel opener diazoxide preserves neuronal-vascular function after cerebral ischemia in newborn pigs [PDF]
, 1999 Background and Purpose-N-Methyl-D-aspartate (NMDA) elicits neuronally mediated cerebral arteriolar vasodilation that is reduced by ischemia/reperfusion (I/R).
David W. Busija +4 more
core +1 more source