Results 11 to 20 of about 38,197 (138)

Gas Signaling Molecules and Mitochondrial Potassium Channels [PDF]

International Journal of Molecular Sciences, 2018
Recently, gaseous signaling molecules, such as carbon monoxide (CO), nitric oxide (NO), and hydrogen sulfide (H2S), which were previously considered to be highly toxic, have been of increasing interest due to their beneficial effects at low concentrations. These so-called gasotransmitters affect many cellular processes, such as apoptosis, proliferation,
Adam Szewczyk, Agnieszka Walewska, Piotr Koprowski   +2 more
exaly   +5 more sources

Loss of Potassium and Chloride Transport Changes PM-Induced Epithelial Dysfunction [PDF]

Journal of Inflammation Research
Sandra Jaworowska, Kamila Maliszewska-Olejniczak, Agnieszka Łukasiak, Jakub Hoser, Mirosław Zając, Piotr Bednarczyk Department of Physics and Biophysics, Institute of Biology, Warsaw University of Life Sciences – SGGW ...
Jaworowska S, Maliszewska-Olejniczak K, Łukasiak A, Hoser J, Zając M, Bednarczyk P   +5 more
doaj   +2 more sources

Cardioprotective Properties of Mannitol-Involvement of Mitochondrial Potassium Channels. [PDF]

Int J Mol Sci, 2021
Cardiac preconditioning (PC) and postconditioning (PoC) are powerful measures against the consequences of myocardial ischemia and reperfusion (I/R) injury. Mannitol—a hyperosmolar solution—is clinically used for treatment of intracranial and intraocular pressure or promotion of diuresis in renal failure.
Feige K, Rubbert J, Raupach A, Stroethoff M, Heinen A, Hollmann MW, Huhn R, Torregroza C.   +7 more
europepmc   +3 more sources

Mitochondrial potassium channels: mitochondria-specific mechanism of regulation [PDF]

Biophysical Reviews
Adam Szewczyk, Bogusz Kulawiak, Piotr Bednarczyk   +2 more
exaly   +2 more sources

Routes for Potassium Ions across Mitochondrial Membranes: A Biophysical Point of View with Special Focus on the ATP-Sensitive K⁺ Channel

Biomolecules, 2021
Potassium ions can cross both the outer and inner mitochondrial membranes by means of multiple routes. A few potassium-permeable ion channels exist in the outer membrane, while in the inner membrane, a multitude of different potassium-selective and ...
Yevheniia Kravenska, Vanessa Checchetto, Ildiko Szabo   +2 more
doaj   +1 more source

Identification of the Large-Conductance Ca²⁺-Regulated Potassium Channel in Mitochondria of Human Bronchial Epithelial Cells

Molecules, 2021
Mitochondria play a key role in energy metabolism within the cell. Potassium channels such as ATP-sensitive, voltage-gated or large-conductance Ca2+-regulated channels have been described in the inner mitochondrial membrane.
Aleksandra Sek, Rafal P. Kampa, Bogusz Kulawiak, Adam Szewczyk, Piotr Bednarczyk   +4 more
doaj   +1 more source

Mitochondrial potassium channels in Dictyostelium discoideum [PDF]

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2012
Mitochondria are crucial not only in energy metabolism but also in regulation of cell senescence and apoptosis. The strict control of inner mitochondrial membrane permeability and selective ion transport is essential for mitochondria functioning. Potassium ions homeostasis is an important process for mitochondrial optimal functioning.
Laskowski, Michal, Szewczyk, Adam, Kicinska, Anna, Jarmuszkiewicz, Wieslawa   +3 more
openaire   +1 more source

Putative Structural and Functional Coupling of the Mitochondrial BKCa Channel to the Respiratory Chain. [PDF]

PLoS ONE, 2013
Potassium channels have been found in the inner mitochondrial membranes of various cells. These channels regulate the mitochondrial membrane potential, the matrix volume and respiration. The activation of these channels is cytoprotective.
Piotr Bednarczyk, Mariusz R Wieckowski, Malgorzata Broszkiewicz, Krzysztof Skowronek, Detlef Siemen, Adam Szewczyk   +5 more
doaj   +1 more source

The Mitochondrial K Channel as a Receptor for Potassium Channel Openers [PDF]

Journal of Biological Chemistry, 1996
The biochemical properties of the mitochondrial KATP channel are very similar to those of plasma membrane KATP channels, including inhibition by low concentrations of ATP and glyburide (Paucek, P., Mironova, G., Mahdi, F., Beavis, A. D., Woldegiorgis, G., and Garlid, K. D. (1992) J. Biol. Chem. 267, 26062-26069).
K D, Garlid, P, Paucek, V, Yarov-Yarovoy, X, Sun, P A, Schindler   +4 more
openaire   +2 more sources

Single channel properties of mitochondrial large conductance potassium channel formed by BK-VEDEC splice variant

Scientific Reports, 2021
The activation of mitochondrial large conductance calcium-activated potassium (mitoBKCa) channels increases cell survival during ischemia/reperfusion injury of cardiac cells.
Shur Gałecka, Bogusz Kulawiak, Piotr Bednarczyk, Harpreet Singh, Adam Szewczyk   +4 more
doaj   +1 more source