Results 11 to 20 of about 38,961 (265)

Gas Signaling Molecules and Mitochondrial Potassium Channels [PDF]

International Journal of Molecular Sciences, 2018
Recently, gaseous signaling molecules, such as carbon monoxide (CO), nitric oxide (NO), and hydrogen sulfide (H2S), which were previously considered to be highly toxic, have been of increasing interest due to their beneficial effects at low concentrations. These so-called gasotransmitters affect many cellular processes, such as apoptosis, proliferation,
Agnieszka Walewska, Adam Szewczyk, Piotr Koprowski   +2 more
exaly   +6 more sources

Mitochondrial potassium and chloride channels.

Acta Biochimica Polonica, 2000
Channels selective for potassium or chloride ions are present in inner mitochondrial membranes. They probably play an important role in mitochondrial events such as the formation of delta pH and regulation of mitochondrial volume changes. Mitochondrial potassium and chloride channels could also be the targets for pharmacologically active compounds such
A, Kicińska, G, D bska, W, Kunz, A, Szewczyk   +3 more
openaire   +4 more sources

Mitochondrial potassium channels and reactive oxygen species [PDF]

FEBS Letters, 2010
Pretreatment of tissues with potassium channel openers (KCO's) has been observed to be cytoprotective in a broad variety of insults. This phenomenon has been proposed to be intimately linked to activation of mitochondrial potassium channels which apparently modulate the mitochondrial production of reactive oxygen species (ROS).
Malinska, Dominika, Mirandola, Sandra R., Kunz, Wolfram S.   +2 more
openaire   +3 more sources

Mitochondrial potassium channels in cell death

Biochemical and Biophysical Research Communications, 2018
Mitochondria are intracellular organelles involved in several processes from bioenergetics to cell death. In the latest years, ion channels are arising as new possible targets in controlling several cellular functions. The discovery that several plasma membrane located ion channels have intracellular counterparts, has now implemented this consideration
Vanessa Checchetto, Michele Azzolini, Roberta Peruzzo, Paola Capitanio, Luigi Leanza   +4 more
openaire   +4 more sources

Role of mitochondrial potassium channels in ageing

Mitochondrion
Ageing is described as an inevitable decline in body functions over time and an increase in susceptibility to age-related diseases. Therefore, the increase of life expectancy is also viewed as a condition in which many elderly will develop age-related diseases and disabilities, such as cardiovascular, metabolic, neurological and oncological ones ...
Flori L., Spezzini J., Calderone V., Testai L.   +3 more
openaire   +3 more sources

Interaction of mitochondrial potassium channels with the permeability transition pore [PDF]

FEBS Letters, 2009
Three types of potassium channels cooperate with the permeability transition pore (PTP) in the inner mitochondrial membranes of various tissues, mtK(ATP), mtBK, and mtKv1.3. While the latter two share similarities with their plasma membrane counterparts, mtK(ATP) exhibits considerable differences with the plasma membrane K(ATP)‐channel.
Cheng, Yu, Debska-Vielhaber, Grazyna, Siemen, Detlef   +2 more
openaire   +3 more sources

Mitochondrial Potassium Channels as Pharmacological Target for Cardioprotective Drugs [PDF]

Medicinal Research Reviews, 2014
AbstractBrief periods of ischemia are known to confer to the myocardium an increased resistance to the injury due to a later and more prolonged ischemic episode. This phenomenon, known as ischemic preconditioning (IPreC), is ensured by different biological mechanisms.
TESTAI, LARA, RAPPOSELLI, SIMONA, MARTELLI, ALMA, BRESCHI, MARIA CRISTINA, CALDERONE, VINCENZO   +4 more
openaire   +4 more sources

Loss of Potassium and Chloride Transport Changes PM-Induced Epithelial Dysfunction [PDF]

Journal of Inflammation Research
Sandra Jaworowska, Kamila Maliszewska-Olejniczak, Agnieszka Łukasiak, Jakub Hoser, Mirosław Zając, Piotr Bednarczyk Department of Physics and Biophysics, Institute of Biology, Warsaw University of Life Sciences – SGGW ...
Jaworowska S, Maliszewska-Olejniczak K, Łukasiak A, Hoser J, Zając M, Bednarczyk P   +5 more
doaj   +2 more sources

Cardioprotective Properties of Mannitol-Involvement of Mitochondrial Potassium Channels. [PDF]

Int J Mol Sci, 2021
Cardiac preconditioning (PC) and postconditioning (PoC) are powerful measures against the consequences of myocardial ischemia and reperfusion (I/R) injury. Mannitol—a hyperosmolar solution—is clinically used for treatment of intracranial and intraocular pressure or promotion of diuresis in renal failure.
Feige K, Rubbert J, Raupach A, Stroethoff M, Heinen A, Hollmann MW, Huhn R, Torregroza C.   +7 more
europepmc   +3 more sources

Physiology of mitochondrial potassium channels

, 2012
The inner membrane of the ATP-producing organelles of endosymbiotic origin, mitochondria, has long been considered to be poorly permeable to cations and anions, since the strict control of inner mitochondrial membrane permeability is crucial for efficient ATP synthesis.
SZABO', ILDIKO', LEANZA, LUIGI, Gulbins E, Zoratti M.   +3 more
openaire   +2 more sources