Mitochondrial Potassium Channels as Druggable Targets [PDF]
Biomolecules, 2020 Mitochondrial potassium channels have been described as important factors in cell pro-life and death phenomena. The activation of mitochondrial potassium channels, such as ATP-regulated or calcium-activated large conductance potassium channels, may have ...
Antoni Wrzosek +3 more
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Multidimensional Regulation of Cardiac Mitochondrial Potassium Channels [PDF]
Cells, 2021 Mitochondria play a fundamental role in the energetics of cardiac cells. Moreover, mitochondria are involved in cardiac ischemia/reperfusion injury by opening the mitochondrial permeability transition pore which is the major cause of cell death.
Bogusz Kulawiak +2 more
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Alternative Targets for Modulators of Mitochondrial Potassium Channels [PDF]
Molecules, 2022 Mitochondrial potassium channels control potassium influx into the mitochondrial matrix and thus regulate mitochondrial membrane potential, volume, respiration, and synthesis of reactive oxygen species (ROS).
Antoni Wrzosek +4 more
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Mitochondrial potassium channels: A novel calcitriol target [PDF]
Cellular & Molecular Biology Letters, 2022 Background Calcitriol (an active metabolite of vitamin D) modulates the expression of hundreds of human genes by activation of the vitamin D nuclear receptor (VDR).
Anna M. Olszewska +4 more
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Redox Regulation of Mitochondrial Potassium Channels Activity [PDF]
AntioxidantsRedox reactions exert a profound influence on numerous cellular functions with mitochondria playing a central role in orchestrating these processes. This pivotal involvement arises from three primary factors: (1) the synthesis of reactive oxygen species (
Joanna Lewandowska +3 more
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Understanding mitochondrial potassium channels: 33 years after discovery [PDF]
Acta Biochimica PolonicaMitochondrial investigations have extended beyond their traditional functions, covering areas such as ATP synthesis and metabolism. Mitochondria are now implicated in new functional areas such as cytoprotection, cellular senescence, tumor function and ...
Adam Szewczyk
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Gas Signaling Molecules and Mitochondrial Potassium Channels. [PDF]
Int J Mol Sci, 2018 Recently, gaseous signaling molecules, such as carbon monoxide (CO), nitric oxide (NO), and hydrogen sulfide (H2S), which were previously considered to be highly toxic, have been of increasing interest due to their beneficial effects at low concentrations. These so-called gasotransmitters affect many cellular processes, such as apoptosis, proliferation,
Walewska A, Szewczyk A, Koprowski P.
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Current Challenges of Mitochondrial Potassium Channel Research
Frontiers in Physiology, 2022 In this paper, the current challenges of mitochondrial potassium channels research were critically reviewed. Even though recent progress in understanding K+ traffic in mitochondria has been substantial, some basic issues of this process remain unresolved.
Bogusz Kulawiak, Adam Szewczyk
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Cardioprotective Effects of Grapefruit IntegroPectin Extracted via Hydrodynamic Cavitation from By-Products of Citrus Fruits Industry: Role of Mitochondrial Potassium Channels [PDF]
Foods, 2022 Citrus flavonoids are well-known for their beneficial effects at the cardiovascular and cardio-metabolic level, but often the encouraging in vitro results are not confirmed by in vivo approaches; in addition, the clinical trials are also inconsistent ...
Lorenzo Flori +7 more
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Methods of Measuring Mitochondrial Potassium Channels: A Critical Assessment. [PDF]
Int J Mol Sci, 2022 In this paper, the techniques used to study the function of mitochondrial potassium channels are critically reviewed. The majority of these techniques have been known for many years as a result of research on plasma membrane ion channels. Hence, in this review, we focus on the critical evaluation of techniques used in the studies of mitochondrial ...
Walewska A +8 more
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